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Institut für Physiologie und Pathophysiologie

Publikationen 2010 - 2012

2012

69.

Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A. No Evidence for a Functional Role of Bi-Directional Notch Signaling during Angiogenesis. PLoS One. 2012;7(12):e53074. doi: 10.1371/journal.pone.0053074. Epub 2012 Dec 28.

68.

Djuric Z, Muhammed K, Fleming T, Murikinati S, Piel D, von Bauer R, Bea F, Herzig S,  Zeier M, Liou HC, Pizzi M, Isermann B, Hecker M, Schwaninger M, Bierhaus A, Nawroth PP. Targeting NFκB subunit-specific activation prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012;18(1):1375-86. doi: 10.2119/molmed.2012.00282.

67.

Suresh Babu S, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal. 2012 Dec 11;5(254):ra91. doi: 10.1126/scisignal.2003173

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66.

Cattaruzza M, Nogoy N, Wojtowicz A, Hecker M. Zinc finger motif-1 antagonizes PDGF-BB-induced growth and dedifferentiation of vascular smooth muscle cells. FASEB J. 2012 Dec;26(12):4864-75. Epub 2012 Aug 20.

65.

Drews O. High-resolution separation of cardiovascular proteomes: two-dimensional electrophoresis and liquid chromatography. Circ Cardiovasc Genet. 2012 Oct 1;5(5):592. doi: 10.1161/CIRCGENETICS.110.958637.

64.

Pfisterer L, Feldner A, Hecker, M, Korff T. Hypertension impairs myocardin function - a novel mechanism facilitating arterial remodeling. Cardiovasc Res. 2012 Oct 1;96(1):120-9. Epub 2012 Jul 26.

63.

Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ. Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Ther. 2012 Aug;19(8):800-9. Epub 2011 Sep 29.

62.

Cattaruzza M, Wagner AH, Hecker M. Mechanosensitive pro-inflammatory gene expression in vascular cells. In: Mechanical Stretch and Cytokines, Mechanosensitivity in Cells and Tissues, Vol. 5. A. Kamkin, I. Kiseleva (Eds.) Springer Science+Business Media B. V. 2012, pp. 59-86.

61.

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M. Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

60.

Rewerk S, Meyer R, Hecker M, Korff T. Durch die Augen von Laplace: Die Rolle der Wandspannung bei Varikosis. Phlebologie 2012;41(2):61-7

59.

Stojanovic T, Wagner A, Schöndube FA, Hecker M. Pre-Transplant Therapy in Experimental Heart Transplantation. In: Cardiac Transplantation. Susan D. Moffatt-Bruce (Ed.) InTech. 2012, pp. 143-154. ISBN 978-953-51-0000-3

58.

Navid F, Kolbe L, Stäb F, Korff T, Neufang G. UV-radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells. Exp Dermatol. 2012 Feb;21(2):147-53. doi: 10.1111/j.1600-0625.2011.01416.x. Epub 2011 Dec 6.

2011

57.

Feldner A, Otto H, Rewerk S, Hecker M, Korff T. Experimental hypertension triggers varicosis-like maladaptive venous remodeling through activator protein-1. FASEB J. 2011 Oct;25(10):3613-21. Epub 2011 Jun 17.

56.

Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M. Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells. Blood. 2011 Sep 29;118(13):3734-42. Epub 2011 Aug 10.

55.

Brecht K, Weigert A, Hu J, Popp R, Fisslthaler B, Korff T, Fleming I, Geisslinger G, Brüne B. Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. FASEB J. 2011 Jul;25(7):2408-17. Epub 2011 Mar 30.

54.

Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R, Grau S, Hiraoka N, Eckstein V, Ecker R, Korff T, von Deimling A, Unterberg A, Beckhove P, Herold-Mende CC. Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived transforming growth factor-betas. Clin Cancer Res. 2011 Jul 1;17(13):4296-308. Epub 2011 Apr 8.

53.

Wang Q, Gorbey S, Pfister F, Höger S, Dorn-Beineke A, Krügel K, Berrone E, Wu L, Korff T, Lin J, Busch S, Reichenbach A, Feng Y, Hammes HP. Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic Retinopathy. Cell Physiol Biochem. 2011;27(6):769-82. Epub 2011 Jun 17.

52.

Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H. Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. Basic Res Cardiol. 2011 Jun;106(4):551-61. Epub 2011 Mar 12.

51.

Hoffmann SC, Wabnitz GH, Samstag Y, Moldenhauer G, Ludwig T. Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy. Int J Cancer. 2011 May 1;128(9):2096-104. doi: 10.1002/ijc.25556.

50.

Hoffmann S, Hosseini BH, Hecker M, Louban I, Bulbuc N, Garbi N, Wabnitz GH, Samstag Y, Spatz JP, Hämmerling GJ. Single cell force spectroscopy of T cells recognizing a myelin-derived peptide on antigen presenting cells. Immunol Lett. 2011 Apr 30;136(1):13-20. Epub 2010 Nov 26.

49.

Hoffmann SC, Cohnen A, Ludwig T, Watzl C. 2B4 engagement mediates rapid LFA-1 and actin-dependent NK cell adhesion to tumor cells as measured by single cell force spectroscopy. J Immunol. 2011 Mar 1;186(5):2757-64. Epub 2011 Jan 26.

48.

Braun J, Hoffmann SC, Feldner A, Ludwig T, Henning R, Hecker M, Korff T. Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):297-305. Epub 2010 Dec 2.

2010

47.

Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T. IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. Epub 2010 Aug 13.

46.

Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M. Zyxin mediation of stretch-induced gene expression in human endothelial cells. Circ Res. 2010 Oct 1;107(7):898-902. Epub 2010 Aug 12. Erratum in: Circ Res.2010 Oct 29;107(9):e15-6.

45.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M. Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 2010 Jul 1;120(7):2307-18. Epub 2010 Jun 14.

44.

Lührmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner AH. Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. Exp Lung Res. 2010 Mar;36(2):85-93.

43.

Wagner AH. Physiologie und Pathophysiologie der venösen Hämodynamik. In: Diagnostik und Therapie der Varikose. 1st Edition. Noppeney T, Nüllen  H (Eds.) Springer Berlin Heidelberg 2010, pp. 51-60. ISBN Print 978-3-642-05365-8. ISBN eBook 978-3-642-05366-5.


Neue Publikationen

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]

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Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

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Simulation Strategies for Calcium Microdomains and Calcium Noise. Adv Exp Med Biol. 2020;1131:771-797. doi: 10.1007/978-3-030-12457-1_31.

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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

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Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. doi: 10.1002/glia.23683. Epub 2019 Jul 17.

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4.2 Kreislauf. In: Physiologie hoch2 (Gründer S, Schlüter KD, eds.) Urban & Fischer Verlag/Elsevier GmbH 2019, pp. 192-225. ISBN 978-3-437-43461-7

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The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain. FASEB J. 2019 Nov;33(11):12812-12824. doi: 10.1096/fj.201901385RR. Epub 2019 Aug 30.

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TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019 Nov;29(11):1038-1048. doi: 10.1002/hipo.23094. Epub 2019 Apr 19.

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The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31.

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Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

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Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells. Life Sci. 2019 Sep 1;232:116620. doi: 10.1016/j.lfs.2019.116620. Epub 2019 Jul 7.

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Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

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Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4035
Telefax:+49 6221 54-4038
E-Mail:sekretariat.hecker@
physiologie.uni-heidelberg.de