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Institut für Physiologie und Pathophysiologie

Publications 2012 - 2014

2014

72.

Fiore R, Rajman M, Schwale C, Bicker S, Antoniou A, Bruehl C, Draguhn A, Schratt G. MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression. EMBO J. 2014 Oct 1;33(19):2231-46. doi: 10.15252/embj.201487921. Epub 2014 Aug 5.

71.

Thome C, Kelly T, Yanez A, Schultz C, Engelhardt M, Cambridge SB, Both M, Draguhn A, Beck H, Egorov AV. Axon-carrying dendrites convey privileged synaptic input in hippocampal neurons. Neuron. 2014 Sep 17;83(6):1418-30. doi: 10.1016/j.neuron.2014.08.013. Epub 2014 Sep 4.

70.

Lemak MS, Voloshanenko O, Draguhn A, Egorov AV. KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons. Front Cell Neurosci. 2014 Aug 27;8:255. doi: 10.3389/fncel.2014.00255. eCollection 2014.

69.

Schönberger J, Draguhn A, Both M. Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes. Front Neural Circuits. 2014 Aug 25;8:103. doi: 10.3389/fncir.2014.00103. eCollection 2014.

68.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel. J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

67.

Kann O, Papageorgiou IE, Draguhn A. Highly energized inhibitory interneurons are a central element for information processing in cortical networks. J Cereb Blood Flow Metab. 2014 Aug;34(8):1270-82. doi: 10.1038/jcbfm.2014.104. Epub 2014 Jun 4.

66.

Pfeiffer T, Draguhn A, Reichinnek S, Both M. Optimized temporally deconvolved Ca2+ imaging allows identification of spatiotemporal activity patterns of CA1 hippocampal ensembles. Neuroimage. 2014 Jul;94:239-49. doi: 10.1016/j.neuroimage.2014.03.030. Epub 2014 Mar 17.

65.

Fischer V, Both M, Draguhn A, Egorov AV. Choline-Mediated Modulation of Hippocampal Sharp Wave-Ripple Complexes in vitro. J Neurochem.  2014 Jun;129(5):792-805. doi: 10.1111/jnc.12693. Epub 2014 Mar 19.

64.

Draguhn A, Keller M, Reichinnek S. Coordinated network activity in the hippocampus. Front Neurol Neurosci. 2014;34:26-35. doi: 10.1159/000357026. Epub 2014 Apr 16.

63.

Yanovsky Y, Ciatipis M, Draguhn A, Tort AB, Brankačk J. Slow oscillations in the mouse hippocampus entrained by nasal respiration. J Neurosci. 2014 Apr 23;34(17):5949-64. doi: 10.1523/JNEUROSCI.5287-13.2014.

2013

62.

Zylla MM, Zhang X, Reichinnek S, Draguhn A, Both M. Cholinergic Plasticity of Oscillating Neuronal Assemblies in Mouse Hippocampal Slices. PLoS One. 2013 Nov 18;8(11): e80718. doi:10.1371/journal.pone.0080718

61.

Diego F, Reichinnek S, Both M, Hamprecht FA. Automated identification of neuronal activity from calcium imaging by sparse dictionary learning. In: 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI). 2013. pp. 1058-1061.

60.

Duhme N, Schweizer PA, Thomas D, Becker R, Schröter J, Barends TR, Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J. 2013 Sep;34(35):2768-75. doi: 10.1093/eurheartj/ehs391. Epub 2012 Nov 23.

59.

Egorov AV, Draguhn A. Development of coherent neuronal activity patterns in mammalian cortical networks: common principles and local hetereogeneity. Mech Dev. 2013 Jun-Aug;130(6-8):412-23. doi: 10.1016/j.mod.2012.09.006. Epub 2012 Sep 29.

58.

Viereckel T, Kostic M, Bähner F, Draguhn A, Both M. Effects of the GABA-uptake blocker NNC-711 on spontaneous sharp wave-ripple complexes in mouse hippocampal slices. Hippocampus. 2013 May;23(5):323-9. doi: 10.1002/hipo.22104. Epub 2013 Mar 5.

57.

Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A. Hippocampal Network Oscillations in APP/APLP2-Deficient Mice. PLoS One. 2013 Apr 9;8(4):e61198. doi: 10.1371/journal.pone.0061198. Print 2013.

56.

Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R. Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol. 2013 Mar;11(3):e1001506. doi: 10.1371/journal.pbio.1001506. Epub 2013 Mar 12.

55.

Hermann D, Mezler M, Swensen A, Bruehl C, Obergrußberger A, Wicke K, Schoemaker H, Gross G, Draguhn A, Nimmrich V. Establishment of a Secondary Screening Assay for P/Q-type Calcium Channel Blockers. Comb Chem High Throughput Screen. 2013 Mar 1;16(3):233-43.

54.

Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, Bruehl C, Nimmrich V. Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers. Eur J Pharmacol. 2013 Feb 28;702(1-3):44-55. doi: 10.1016/j.ejphar.2013.01.030. Epub 2013 Jan 30.

53.

Scheffzük C, Kukushka VI, Vyssotski AL, Draguhn A, Tort AB, Brankačk J. Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology. 2013 Feb;65:123-133. doi: 10.1016/j.neuropharm.2012.09.014. Epub 2012 Oct 9.

52.

Kranig SA, Duhme N, Waldeck C, Draguhn A, Reichinnek S, Both M. Different functions of hyperpolarization-activated cation channels for hippocampal sharp waves and ripples in vitro. Neuroscience. 2013 Jan 3;228:325-33. doi: 10.1016/j.neuroscience.2012.10.050. Epub 2012 Nov 2.

51.

Tort AB, Scheffer-Teixeira R, Souza BC, Draguhn A, Brankačk J. Theta-associated high-frequency oscillations (110-160Hz) in the hippocampus and neocortex. Prog Neurobiol. 2013 Jan;100:1-14. doi: 10.1016/j.pneurobio.2012.09.002. Epub 2012 Sep 25.

2012

50.

Brankačk J, Scheffzük C, Kukushka VI, Vyssotski AI, Tort AB, Draguhn A. Distinct features of fast oscillations in phasic and tonic rapid eye movement sleep. J Sleep Res. 2012 Dec;21(6):630-3. Epub 2012 Jul 20.

49.

Krieger M, Both M, Kranig SA, Pitzer C, Klugmann M, Vogt G, Draguhn A, Schneider A. The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions. Sci Rep. 2012;2:697. Epub 2012 Sep 26.

48.

Traub RD, Schmitz D, Maier N, Whittington MA, Draguhn A. Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations. J Eur J Neurosci. 2012 Sep;36(5):2650-60. Epub 2012 Jun 15.

47.

Schmidt S, Bruehl C, Frahm C, Redecker C, Witte OW.  Age dependence of excitatory-inhibitory balance following stroke. Neurobiol Aging. 2012 Jul;33(7):1356-63. Epub 2011 Jan 22.

46.

Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V. Development and Validation of a Fluorescence-based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers. Comb Chem High Throughput Screen. 2012 Jun 1;15(5):372-85.

45.

Korte M, Herrmann U, Zhang X, Draguhn A. The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models.Exp Brain Res. 2012 Apr;217(3-4):435-40. Epub 2011 Oct 18.

44.

Reichinnek S, von Kameke A, Hagenston AM, Freitag E, Roth FC, Bading H, Hasan MT, Draguhn A, Both M. Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro. Neuroimage. 2012 Mar;60(1):139-152.

43.

Roth FC, Draguhn A. GABA Metabolism and Transport: Effects on Synaptic Efficacy. Neural Plast. 2012;2012:805830. Epub 2012 Feb 23.


Neue Publikationen

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Amyloid, APP, and Electrical Activity of the Brain. Neuroscientist. 2019 Nov 29:1073858419882619. doi: 10.1177/1073858419882619. [Epub ahead of print]

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Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples. Appl Microbiol Biotechnol. 2019 Nov 28. doi: 10.1007/s00253-019-10242-1. [Epub ahead of print]

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]

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Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

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Simulation Strategies for Calcium Microdomains and Calcium Noise. Adv Exp Med Biol. 2020;1131:771-797. doi: 10.1007/978-3-030-12457-1_31.

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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

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Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Sci Rep. 2019 Dec 3;9(1):18224. doi: 10.1038/s41598-019-54807-6.

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Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. doi: 10.1002/glia.23683. Epub 2019 Jul 17.

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4.2 Kreislauf. In: Physiologie hoch2 (Gründer S, Schlüter KD, eds.) Urban & Fischer Verlag/Elsevier GmbH 2019, pp. 192-225. ISBN 978-3-437-43461-7

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The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain. FASEB J. 2019 Nov;33(11):12812-12824. doi: 10.1096/fj.201901385RR. Epub 2019 Aug 30.

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TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019 Nov;29(11):1038-1048. doi: 10.1002/hipo.23094. Epub 2019 Apr 19.

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The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31.

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Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

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Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4035
Telefax:+49 6221 54-4038
E-Mail:sekretariat.hecker@
physiologie.uni-heidelberg.de