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Institute of Physiology and Pathophysiology

Image Processing

The acquisition of raw image series with a microscope system is usually followed by methods of image processing. On the one hand, the purpose can be an improvement of the image quality, like noise reduction or deconvolution. On the other hand it can be an automated analysis of the experimental data. In our group, the programming work is mainly done with IDL software (Interactive data language).


Model-based noise reduction

Improving the signal-to-noise ratio, e.g. by using wavelet transforms for the detection of calcium sparks from the background noise.


Automated detection and analysis

Example: Development of a software to detect elementary calcium release events and analyze their frequency and morphology.



A point source of light is displayed by the optics of a microscope in a characteristic way that is known as the "point spread function" (PSF). This PSF can be eather measured or calculated for the microscope system and then be used to compute undistorted data from the acquired images. The deconvolved images are clearer and less blurry.


24.10.2017       13:30   /   INF 327, Seminar Room 1


Hypoxia and uterine contractions: Something old and something new

Prof. Dr. Susan Wray

Dept. of Cellular and Molecular Physiology, University of Liverpool, United Kingdom


24.10.2017       18:00   /   INF 410 (Med. Clinic), Auditorium


Calcium in the heart: in and out of control

Prof. Dr. David Eisner

Manchester Institute for Collaborative Research on Ageing, University of Manchester, United Kingdom

(seminar of Heidelberg University Hospital and German Center for Cardiovascular Disease (DZHK); host: Prof. Dr. M. Hecker, Inst. of Physiology and Pathophysiology, Heidelberg University)


Recent Publications


Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.


Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.


Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8


NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.

Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg


Phone:+49 6221 54-4056
Fax:+49 6221 54-6364