Arbeitsgebiete
Schwerpunkte
- Mitochondrien und neurometabolische Kopplung in intakten Neuronen
- Energiemetabolismus bei schnellen Netzwerk-Oszillationen
- Aktivierung von Mikrogliazellen und neuronale (Fehl)Funktionen
Methoden
- Fluoreszenz-basierte bildgebende Techniken
- Intra- und extrazelluläre Elektrophysiologie
- Sauerstoff- und Ionen-sensitive Mikroelektroden
- Organotypische Schnittkulturen des Hippocampus
Forschungsförderung
| Theoretische Biologie: Robustheit, Modularität und evolutionäres Design lebender Systeme |
| Mesiale Temporallappen-Epilepsien |
| Entwicklungsstörungen im Nervensystem |
| Die Bedeutung nicht-neuronaler Zellen bei neurologischen Erkrankungen |
Neue Publikationen
* | Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue. Mol Ther Methods Clin Dev. 2021 Jun 11;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11. |
* | Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2021 Apr;112:137-144. doi: 10.1016/j.semcdb.2020.08.001. Epub 2020 Aug 15. |
* | Editorial: Calcium Homeostasis in Skeletal Muscle Function, Plasticity, and Disease. Front Physiol. 2021 Mar 26;12:671292. doi: 10.3389/fphys.2021.671292. eCollection 2021. |
* | Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn. Acta Physiol (Oxf). 2021 Mar 17:e13647. doi: 10.1111/apha.13647. Online ahead of print. |
* | Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient.Basic Res Cardiol. 2021 Mar 17;116(1):18. doi: 10.1007/s00395-021-00860-0. |
* | Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540 |
* | Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples. Biopreserv Biobank. 2021 Mar 1. doi: 10.1089/bio.2020.0046. Online ahead of print. |
* | Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2021 Mar;258(2):239-248. doi: 10.1007/s00709-020-01550-9. Epub 2020 Sep 2. |
* | Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. PMID: 33630168 |
* | Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021 Feb 15;399(2):112446. doi: 10.1016/j.yexcr.2020.112446. Epub 2021 Jan 7. |
* | A New Apparatus for Recording Evoked Responses to Painful and Non-painful Sensory Stimulation in Freely Moving Mice. Front Neurosci. 2021 Feb 12;15:613801. doi: 10.3389/fnins.2021.613801. eCollection 2021. |
* | Inhibition of cyclooxygenase activity by diclofenac attenuates varicose remodeling of mouse veins. Vessel Plus 2021 Feb 7;5:7. doi: 10.20517/2574-1209.2020.52. |
* | Integrated information theory does not make plant consciousness more convincing. Biochem Biophys Res Commun. 2021 Jan 21:S0006-291X(21)00057-7. doi: 10.1016/j.bbrc.2021.01.022. Online ahead of print. |
* | AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Jan 20:cvab012. doi: 10.1093/cvr/cvab012. Online ahead of print. |
* | Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group. Lab Anim. 2020 Dec 7:23677220968589. doi: 10.1177/0023677220968589. Online ahead of print. |
* | Debunking a myth: plant consciousness. Protoplasma. 2020 Nov 16. doi: 10.1007/s00709-020-01579-w. Review. Online ahead of print. |
Institut für Universität Heidelberg Im Neuenheimer Feld 326 69120 Heidelberg
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