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Institut für Physiologie und Pathophysiologie

Arbeitsgebiete

Fast Network Oscillations


Rhythmic activity is a key functional feature of the brain, as evident from the well-known EEG-rhythms. Meanwhile, many neuroscientists agree that such network oscillations are «meaningful» and provide an important background for temporal coding of information. In our group we focus on one type of network oscillations in the rodent hippocampus, namely «ripples» at ~200 Hz as originally described by John O´Keefe, G. Buszáki and others. We want to elucidate the precise mechanisms by which neurons are entrained to fire at high precision within these short (5 ms) cycles. Moreover, we would like to find out why certain neurons participate in this network while others do not.

Function of GABAergic Synapses

The complex organisation of central synapses offers multiple mechanisms for regulation and modulation of synaptic strength. We focus on inhibitory synapses in the mammalian CNS which use GABA (gamma-aminobutyric acid) as transmitter. The availability of GABA is regulated by its synthesis, degradation and after release-uptake. In situations of over-excitability, the GABA-synthetizing enzyme GAD is up-regulated while a decrease of neuronal activity leads to a down-regulation of GAD. Thus, cellular GABA content seems to be an activity-dependent, variable parameter. We propose that the presynaptic GABA metabolism is a true and autonomous mechanism of synaptic plasticity. We are presently testing this hypothesis using various electrophysiological, histological and biochemical techniques.

Synaptic Physiology and Pharmacology of Epilepsy


Neue Publikationen

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Theta-gamma coupling during REM sleep depends on breathing rate. Sleep. 2021 Dec 10;44(12):zsab189. doi: 10.1093/sleep/zsab189

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Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices. Front Neural Circuits. 2021 Dec 3;15:758939. doi: 10.3389/fncir.2021.758939. eCollection 2021.

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NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells. Cells. 2021 Nov 24; 10(12):3293. doi: 10.3390/cells10123293

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Comparative lipid profiling of murine and human atherosclerotic plaques using high-resolution MALDI MSI. Pflugers Arch. 2021 Nov 19. doi: doi.org/10.1007/s00424-021-02643-x. Online ahead of print.

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Lin11-Isl1-Mec3 Domain Proteins as Mechanotransducers in Endothelial and Vascular Smooth Muscle Cells. Front Physiol. 2021 Nov 19;12:769321. doi: 10.3389/fphys.2021.769321. eCollection 2021. Review.

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Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals. J Neuroinflammation. 2021 Nov 2;18(1):252. doi: 10.1186/s12974-021-02286-w.

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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Nov 1;117(12):2459-2473. doi: 10.1093/cvr/cvab012.

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Understanding plant behavior: a student perspective: response to Van Volkenburgh et al. Trends Plant Sci. 2021 Nov;26(11):1089-1090. doi: 10.1016/j.tplants.2021.08.014. Epub 2021 Sep 18.

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Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma. Endocr Relat Cancer. 2021 Oct 18;28(12):757-772. doi: 10.1530/ERC-21-0211.

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Inverse Regulation of Confluence-Dependent ADAMTS13 and von Willebrand Factor Expression in Human Endothelial Cells. Thromb Haemost. 2021 Aug 5. doi: 10.1055/s-0041-1733800. Online ahead of print.

Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4056
Telefax:+49 6221 54-6364
E-Mail:susanne.bechtel@
physiologie.uni-heidelberg.de