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Institute of Physiology and Pathophysiology

Cardiovascular Physiology

Director

 

Prof. Dr. Markus Hecker

 

Phone:

+49 6221 54-4036/4035

Fax:

+49 6221 54-4038

E-Mail:

hecker@physiologie.uni-heidelberg.de

 

Secretary

 

Barbara Richards

 

Phone:

+49 6221 54-4035

Fax:

+49 6221 54-4038

E-Mail:

sekretariat.hecker@physiologie.uni-heidelberg.de

Our Field of Research

Our research focuses on the molecular mechanisms underlying pathophysiological and physiological remodelling processes in the cardiovascular system, to define new therapeutic aproaches for cardiovascular disease.

 

At present five working groups and one project team concentrate on various research areas within this field.

 

Scientists of the division are also integrated in a number of local and national research centers and networks:

   


Recent Publications

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Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy. PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.

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Layer Specific Development of Neocortical Pyramidal to Fast Spiking Cell Synapses. Front Cell Neurosci. 2016 Jan 20;9:518. doi: 10.3389/fncel.2015.00518. eCollection 2015.

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Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle. FASEB J. 2016 Feb;30(2):923-32. doi: 10.1096/fj.15-279240. Epub 2015 Nov 6.

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Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway. Neuropharmacology. 2016 Jan 19. pii: S0028-3908(16)30022-3. doi: 10.1016/j.neuropharm.2016.01.023. [Epub ahead of print]

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Interaction of ions with the luminal sides of wild-type and mutated skeletal muscle ryanodine receptors. J Mol Model. 2016 Jan;22(1):37. doi: 10.1007/s00894-015-2906-8. Epub 2016 Jan 19.

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Oxidative Stress in Disease and Aging: Mechanisms and Therapies. Oxid Med Cell Longev. 2016;2016:8786564. doi: 10.1155/2016/8786564. Epub 2015 Dec 10.

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Photographic estimation of wild boar damage to alpine grazing pastures in the Carpathian Mountains of central Romania. Environ Sci Pollut Res Int. 2016 Jan 18. [Epub ahead of print]

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KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons. Histochem Cell Biol. 2016 Jan 16. [Epub ahead of print]

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Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke. J Cereb Blood Flow Metab. 2016 Jan 8. pii: 0271678X15624933. [Epub ahead of print]

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Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice. J Neurosci. 2016 Jan 6;36(1):162-77. doi: 10.1523/JNEUROSCI.2848-15.2016.

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TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7. doi: 10.1073/pnas.1513853113. Epub 2015 Dec 22.

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Colocalization properties of elementary Ca2+ release signals with structures specific to the contractile filaments and the tubular system of intact mouse skeletal muscle fibers. J Struct Biol. 2015 Dec;192(3):366-375. doi: 10.1016/j.jsb.2015.09.018. Epub 2015 Oct 21.

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The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis. 2015 Aug 15. pii: S0969-9961(15)30025-5. doi: 10.1016/j.nbd.2015.08.005. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:sekretariat.draguhn@
physiologie.uni-heidelberg.de