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Institute of Physiology and Pathophysiology

Cardiovascular Physiology

Director

 

Prof. Dr. Markus Hecker

 

Phone:

+49 6221 54-4036/4035

Fax:

+49 6221 54-4038

E-Mail:

hecker@physiologie.uni-heidelberg.de

 

Secretary

 

Barbara Richards

 

Phone:

+49 6221 54-4035

Fax:

+49 6221 54-4038

E-Mail:

sekretariat.hecker@physiologie.uni-heidelberg.de

Our Field of Research

Our research focuses on the molecular mechanisms underlying pathophysiological and physiological remodelling processes in the cardiovascular system, to define new therapeutic aproaches for cardiovascular disease.

 

At present five working groups and one project team concentrate on various research areas within this field.

 

Scientists of the division are also integrated in a number of local and national research centers and networks:

   


Recent Publications

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T-786C single nucleotide polymorphism of the endothelial nitric oxide synthase gene as a risk factor for endothelial dysfunction in polymyalgia rheumatica. Clin Exp Rheumatol. 2015 Aug 27. [Epub ahead of print]

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Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients. J Cereb Blood Flow Metab. J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506. doi: 10.1038/jcbfm.2015.70. Epub 2015 Apr 22.

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The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis. 2015 Aug 15. pii: S0969-9961(15)30025-5. doi: 10.1016/j.nbd.2015.08.005. [Epub ahead of print]

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Neuronal Network Oscillations in Neurodegenerative Diseases. Neuromolecular Med. 2015 Sep;17(3):270-84. doi: 10.1007/s12017-015-8355-9. Epub 2015 Apr 29.

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The role of diet and housing-temperature in the production of genetically modified mouse embryos and their developmental capacity after cryopreservation. Theriogenology. 2015 Jul 16. pii: S0093-691X(15)00352-0. doi: 10.1016/j.theriogenology.2015.07.010. [Epub ahead of print]

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S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.

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Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.Tissue Eng Part C Methods. 2015 Aug;21(8):852-61. doi: 10.1089/ten.TEC.2014.0376. Epub 2015 Mar 16.

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Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport? Neuropharmacology. 2015 Aug;95:321-31. doi: 10.1016/j.neuropharm.2015.03.026. Epub 2015 Apr 3.

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Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 2015 Jul;29(7):3076-84. doi: 10.1096/fj.14-267633. Epub 2015 Apr 9

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Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration. Brain Struct Funct. 2015 Jul;220(4):2423-39. doi: 10.1007/s00429-014-0802-0. Epub 2014 May 31.

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Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes. Stem Cells. 2015 Jul;33(7):2208-2218. doi: 10.1002/stem.2009. Epub 2015 May 12.

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JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter. Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.

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A reliable model for gamma oscillations in hippocampal tissue. J Neurosci Res. 2015 Jul;93(7):1067-78. doi: 10.1002/jnr.23590. Epub 2015 Mar 24.

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Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells. J Am Heart Assoc. 2015 Jun 12;4(6). pii: e001712.

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Carnosine metabolism in diabetes is altered by reactive metabolites. Amino Acids. 2015 Jun 17. [Epub ahead of print]

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Enabling the detection of UV signal in multimodal nonlinear microscopy with catalogue lens components. J Microsc. 2015 May 27. doi: 10.1111/jmi.12267. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4035
Fax:+49 6221 54-4038
E-mail:sekretariat.hecker@
physiologie.uni-heidelberg.de