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Institute of Physiology and Pathophysiology

Cardiovascular Physiology

Director

 

Prof. Dr. Markus Hecker

 

Phone:

+49 6221 54-4036/4035

Fax:

+49 6221 54-4038

E-Mail:

hecker@physiologie.uni-heidelberg.de

 

Secretary

 

Barbara Richards

 

Phone:

+49 6221 54-4035

Fax:

+49 6221 54-4038

E-Mail:

sekretariat.hecker@physiologie.uni-heidelberg.de

Our Field of Research

Our research focuses on the molecular mechanisms underlying pathophysiological and physiological remodelling processes in the cardiovascular system, to define new therapeutic aproaches for cardiovascular disease.

 

At present five working groups and one project team concentrate on various research areas within this field.

 

Scientists of the division are also integrated in a number of local and national research centers and networks:

   


Update

 

5.3.2016

 

Poster Awards of the DPG for Heidelberg Physiologists

 

On March 5 at the Annual Meeting of the Deutsche Physiologische Gesellschaft (DPG) the posters with Dr. Nina Ullrich as senior author and Ivelina Kadiyska as first author were awarded the poster prize in their respective sessions.

 

Michela Azzarito, Yann Prudat, Irene C. Marcu, Jan P. Kucera, Nina D. Ullrich. "Reduced excitability and intercellular coupling lead to slow conduction in cultures of stem cell-derived cardiomyocytes." (P22-03). Acta Physiologica. Special Issue: Abstracts of the 95th Annual Meeting of the German Physiological Society, 3–5 March 2016. Volume 216, Issue Supplement S707, pages 85–223.

 

I. Kadiyska, S. Gehrmann, J. Morgenstern, T. Fleming, F. Leuschner, A. H. Wagner, M. Hecker. "15-Deoxy-Δ12,14-prostaglandin J 2  reinforces the anti-inflammatory capacity of endothelial cells with a genetically determined nitric oxide deficit." (P08-15). Acta Physiologica. Special Issue: Abstracts of the 95th Annual Meeting of the German Physiological Society, 3–5 March 2016. Volume 216, Issue Supplement S707, pages 85–223.

  

Recent Publications

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KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons. Histochem Cell Biol. 2016 Jun;145(6):637-46. doi: 10.1007/s00418-015-1397-0. Epub 2016 Jan 16.

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Functional characterization of orbicularis oculi and extraocular muscles. J Gen Physiol. 2016 May;147(5):395-406. doi: 10.1085/jgp.201511542. Epub 2016 Apr 11.

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Satellite microglia display spontaneous electrical activity uncorrelated with activity of the attached neuron. Eur J Neurosci. 2016 Apr 8. doi: 10.1111/ejn.13256. [Epub ahead of print]

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The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis. 2016 Jun;90:75-85. doi: 10.1016/j.nbd.2015.08.005. Epub 2015 Aug 16.

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Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity. 2016 Apr 19;44(4):901-912. doi: 10.1016/j.immuni.2016.04.005.

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Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovasc Res. 2016 Mar 24. pii: cvw066. [Epub ahead of print]

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Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner. Neurobiol Dis. 2016 Mar 18. pii: S0969-9961(16)30063-8. doi: 10.1016/j.nbd.2016.03.018. [Epub ahead of print]

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Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution. Biomed Opt Express. 2016 Jan 15;7(2):525-41. doi: 10.1364/BOE.7.000525. eCollection 2016 Feb 1.

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Impaired theta-gamma coupling in APP-deficient mice. Sci Rep. 2016 Feb 24;6:21948. doi: 10.1038/srep21948.

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Varicose Remodeling of Veins Is Suppressed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors. J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002405. doi: 10.1161/JAHA.115.002405.

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Photographic estimation of wild boar damage to alpine grazing pastures in the Carpathian Mountains of central Romania. Environ Sci Pollut Res Int. 2016 Mar;23(5):4949-4952. Epub 2016 Jan 18.

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High-Field MRI Reveals a Drastic Increase of Hypoxia-Induced Microhemorrhages upon Tissue Reoxygenation in the Mouse Brain with Strong Predominance in the Olfactory Bulb. PLoS One. 2016 Feb 10;11(2):e0148441. doi: 10.1371/journal.pone.0148441. eCollection 2016.

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Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway. Neuropharmacology. 2016 Jan 19;105:228-240. doi: 10.1016/j.neuropharm.2016.01.023. [Epub ahead of print]

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Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke. J Cereb Blood Flow Metab. 2016 Jan 8. pii: 0271678X15624933. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:sekretariat.draguhn@
physiologie.uni-heidelberg.de