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Institute of Physiology and Pathophysiology

Research Areas

Main Focus

 

  • Mitochondria and neurometabolic coupling in intact neurons
  • Energy metabolism during gamma oscillations
  • Free radicals and mitochondrial dysfunction in epilepsy
  • Activation of microglial cells and neuronal (dys)function

 

Methods

 

  • Fluorescence-based imaging techniques
  • Intra- und extracellular electrophysiology
  • Oxygen- and ion-sensitive microelectrodes
  • Organotypic slice cultures of the hippocampus

 

Grants

 

Theoretical biology: robustness, modularity and evolutionary design of living systems Dies ist ein externer Link

Mesial temporal lobe epilepsies Dies ist ein externer Link

  • SFB 665:

Developmental disturbances in the nervous system

  • SFB 507:

Role of non-neuronal cells in neurological disease


24.10.2017       13:30   /   INF 327, Seminar Room 1

 

Hypoxia and uterine contractions: Something old and something new

Prof. Dr. Susan Wray

Dept. of Cellular and Molecular Physiology, University of Liverpool, United Kingdom

  

24.10.2017       18:00   /   INF 410 (Med. Clinic), Auditorium

 

Calcium in the heart: in and out of control

Prof. Dr. David Eisner

Manchester Institute for Collaborative Research on Ageing, University of Manchester, United Kingdom


(seminar of Heidelberg University Hospital and German Center for Cardiovascular Disease (DZHK); host: Prof. Dr. M. Hecker, Inst. of Physiology and Pathophysiology, Heidelberg University)

  

Recent Publications

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AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15; 9: 69–79. Epub 2017 Sep 20. doi: 10.1016/j.omtn.2017.08.014

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Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.

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Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

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Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

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Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8

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NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de