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Institut für Physiologie und Pathophysiologie

Prof. Dr. med. Andreas Draguhn

Publikationsliste

Markierte Titel sind mit dem jeweiligen Abstract auf einer frei zugänglichen Webseite verlinkt.

Originalarbeiten in Journalen mit Peer Review

121.

Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D. Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

120.

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M. Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8.

119.

Zhong W, Ciatipis M, Wolfenstetter T, Jessberger J, Müller C, Ponsel S, Yanovsky Y, Brankačk J, Tort ABL, Draguhn A. Selective entrainment of gamma subbands by different slow network oscillations. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4519-4524. doi: 10.1073/pnas.1617249114. Epub 2017 Apr 10.

118.

Maier P, Kaiser ME, Grinevich V, Draguhn A, Both M. Differential effects of oxytocin on mouse hippocampal oscillations in vitro. Eur J Neurosci. 2016 Dec;44(11):2885-2898. doi: 10.1111/ejn.13412. Epub 2016 Oct 14.

117.

Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Müller UC, Draguhn A. Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels. J Neurosci. 2016 Aug 10;36(32):8356-71. doi: 10.1523/JNEUROSCI.4130-15.2016.

116.

Roth FC, Beyer KM, Both M, Draguhn A, Egorov AV. Downstream effects of hippocampal sharp wave ripple oscillations on medial entorhinal cortex layer V neurons in vitro. Hippocampus. 2016 Dec;26(12):1493-1508. doi: 10.1002/hipo.22623. Epub 2016 Aug 18.

117.

Jessberger J, Zhong W, Brankačk J, Draguhn A. Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice. Neural Plast. 2016;2016:4570831. doi: 10.1155/2016/4570831. Epub 2016 May 10.

116.

Draguhn A. Butterflies and the brain. J Physiol. 2016 May 15;594(10):2559-60. doi: 10.1113/JP272194. No abstract available.

115.

Wogram E, Wendt S, Matyash M, Pivneva T, Draguhn A, Kettenmann H. Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron. Eur J Neurosci. 2016 Jun;43(11):1523-34. doi: 10.1111/ejn.13256. Epub 2016 May 21.

114.

Zhang X, Zhong W, Brankačk J, Weyer SW, Müller UC, Tort AB, Draguhn A. Impaired theta-gamma coupling in APP-deficient mice. Sci Rep. 2016 Feb 24;6:21948. doi: 10.1038/srep21948.

113.

Valiullina F, Zakharova Y, Mukhtarov M, Draguhn A, Burnashev N, Rozov A. The Relative Contribution of NMDARs to Excitatory Postsynaptic Currents is Controlled by Ca(2+)-Induced Inactivation. Front Cell Neurosci. 2016 Jan 29;10:12. doi: 10.3389/fncel.2016.00012. eCollection 2016.

112.

Jappy D, Valiullina F, Draguhn A, Rozov A. GABABR-Dependent Long-Term Depression at Hippocampal Synapses between CB1-Positive Interneurons and CA1 Pyramidal Cells. Front Cell Neurosci. 2016 Jan 28;10:4. doi: 10.3389/fncel.2016.00004. eCollection 2016.

111.

Voinova O, Valiullina F, Zakharova Y, Mukhtarov M, Draguhn A, Rozov A. Layer Specific Development of Neocortical Pyramidal to Fast Spiking Cell Synapses. Front Cell Neurosci. 2016 Jan 20;9:518. doi: 10.3389/fncel.2015.00518. eCollection 2015.

110.

Schwale C, Schumacher S, Bruehl C, Titz S, Schlicksupp A, Kokocinska M, Kirsch J, Draguhn A, Kuhse J. KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons. Histochem Cell Biol. 2016 Jun;145(6):637-46. doi: 10.1007/s00418-015-1397-0. Epub 2016 Jan 16.

109.

Wogram E, Wendt S, Matyash M, Pivneva T, Draguhn A, Kettenmann H. Satellite microglia display spontaneous electrical activity uncorrelated with activity of the attached neuron. Eur J Neurosci. 2016 Apr 8. doi: 10.1111/ejn.13256. [Epub ahead of print]

108.

Voinova O, Valiullina F, Zakharova Y, Mukhtarov M, Draguhn A, Rozov A. Layer Specific Development of Neocortical Pyramidal to Fast Spiking Cell Synapses. Front Cell Neurosci. 2016 Jan 20;9:518. doi: 10.3389/fncel.2015.00518. eCollection 2015.

107.

Nguyen Chi V, Müller C, Wolfenstetter T, Yanovsky Y, Draguhn A, Tort AB, Brankačk J. Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice. J Neurosci. 2016 Jan 6;36(1):162-77. doi: 10.1523/JNEUROSCI.2848-15.2016.

106.

Keller MK, Draguhn A, Both M, Reichinnek S. Activity-dependent plasticity of mouse hippocampal assemblies in vitro. Front Neural Circuits. 2015 May 18;9:21. doi: 10.3389/fncir.2015.00021. eCollection 2015.

105.

Hick M, Herrmann U, Weyer SW, Mallm J, Tschäpe J, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC. Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. Acta Neuropathol. 2015 Jan;129(1):21-37. doi: 10.1007/s00401-014-1368-x. Epub 2014 Nov 29. 

Erratum: 2015 Jan;129(1):161-2. doi: 10.1007/s00401-014-1374-z.

104.

Fiore R, Rajman M, Schwale C, Bicker S, Antoniou A, Bruehl C, Draguhn A, Schratt G. MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression. EMBO J. 2014 Oct 1;33(19):2231-46. doi: 10.15252/embj.201487921. Epub 2014 Aug 5.

103.

Thome C, Kelly T, Yanez A, Schultz C, Engelhardt M, Cambridge SB, Both M, Draguhn A, Beck H, Egorov AV. Axon-carrying dendrites convey privileged synaptic input in hippocampal neurons. Neuron. 2014 Sep 17;83(6):1418-30. doi: 10.1016/j.neuron.2014.08.013. Epub 2014 Sep 4.

102.

Lemak MS, Voloshanenko O, Draguhn A, Egorov AV. KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons. Front Cell Neurosci. 2014 Aug 27;8:255. doi: 10.3389/fncel.2014.00255. eCollection 2014.

101.

Schönberger J, Draguhn A, Both M. Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes. Front Neural Circuits. 2014 Aug 25;8:103. doi: 10.3389/fncir.2014.00103. eCollection 2014.

100.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel. J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

99.

Pfeiffer T, Draguhn A, Reichinnek S, Both M. Optimized temporally deconvolved Ca2+ imaging allows identification of spatiotemporal activity patterns of CA1 hippocampal ensembles. Neuroimage. 2014 Jul;94:239-49. doi: 10.1016/j.neuroimage.2014.03.030. Epub 2014 Mar 17.

98.

Fischer V, Both M, Draguhn A, Egorov AV. Choline-Mediated Modulation of Hippocampal Sharp Wave-Ripple Complexes in vitro. J Neurochem.  2014 Jun;129(5):792-805. doi: 10.1111/jnc.12693. Epub 2014 Mar 19.

97.

Yanovsky Y, Ciatipis M, Draguhn A, Tort AB, Brankačk J. Slow oscillations in the mouse hippocampus entrained by nasal respiration. J Neurosci. 2014 Apr 23;34(17):5949-64. doi: 10.1523/JNEUROSCI.5287-13.2014.

96.

Zylla MM, Zhang X, Reichinnek S, Draguhn A, Both M. Cholinergic Plasticity of Oscillating Neuronal Assemblies in Mouse Hippocampal Slices. PLoS One. 2013 Nov 18;8(11): e80718. doi:10.1371/journal.pone.0080718

95.

Duhme N, Schweizer PA, Thomas D, Becker R, Schröter J, Barends TR, Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J. 2013 Sep;34(35):2768-75. doi: 10.1093/eurheartj/ehs391. Epub 2012 Nov 23.

94.

Egorov AV, Draguhn A. Development of coherent neuronal activity patterns in mammalian cortical networks: common principles and local hetereogeneity. Mech Dev. 2013 Jun-Aug;130(6-8):412-23. doi: 10.1016/j.mod.2012.09.006. Epub 2012 Sep 29.

93.

Viereckel T, Kostic M, Bähner F, Draguhn A, Both M. Effects of the GABA-uptake blocker NNC-711 on spontaneous sharp wave-ripple complexes in mouse hippocampal slices. Hippocampus. 2013 May;23(5):323-9. doi: 10.1002/hipo.22104. Epub 2013 Mar 5.

92.

Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A. Hippocampal Network Oscillations in APP/APLP2-Deficient Mice. PLoS One. 2013 Apr 9;8(4):e61198. doi: 10.1371/journal.pone.0061198. Print 2013.

91.

Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R. Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol. 2013 Mar;11(3):e1001506. doi: 10.1371/journal.pbio.1001506. Epub 2013 Mar 12.

90.

Hermann D, Mezler M, Swensen A, Bruehl C, Obergrußberger A, Wicke K, Schoemaker H, Gross G, Draguhn A, Nimmrich V. Establishment of a Secondary Screening Assay for P/Q-type Calcium Channel Blockers. Comb Chem High Throughput Screen. 2013 Mar 1;16(3):233-43.

89.

Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, Bruehl C, Nimmrich V. Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers. Eur J Pharmacol. 2013 Feb 28;702(1-3):44-55. doi: 10.1016/j.ejphar.2013.01.030. Epub 2013 Jan 30.

88.

Scheffzük C, Kukushka VI, Vyssotski AL, Draguhn A, Tort AB, Brankačk J. Global slowing of network oscillations in mouse neocortex by diazepam. Neuropharmacology. 2013 Feb;65:123-133. doi: 10.1016/j.neuropharm.2012.09.014. Epub 2012 Oct 9.

87.

Kranig SA, Duhme N, Waldeck C, Draguhn A, Reichinnek S, Both M. Different functions of hyperpolarization-activated cation channels for hippocampal sharp waves and ripples in vitro. Neuroscience. 2013 Jan 3;228:325-33. doi: 10.1016/j.neuroscience.2012.10.050. Epub 2012 Nov 2.

86.

Tort AB, Scheffer-Teixeira R, Souza BC, Draguhn A, Brankačk J. Theta-associated high-frequency oscillations (110-160Hz) in the hippocampus and neocortex. Prog Neurobiol. 2013 Jan;100:1-14. doi: 10.1016/j.pneurobio.2012.09.002. Epub 2012 Sep 25.

85.

Brankačk J, Scheffzük C, Kukushka VI, Vyssotski AI, Tort AB, Draguhn A. Distinct features of fast oscillations in phasic and tonic rapid eye movement sleep. J Sleep Res. 2012 Dec;21(6):630-3. Epub 2012 Jul 20.

84.

Krieger M, Both M, Kranig SA, Pitzer C, Klugmann M, Vogt G, Draguhn A, Schneider A. The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions. Sci Rep. 2012;2:697. Epub 2012 Sep 26.

83.

Traub RD, Schmitz D, Maier N, Whittington MA, Draguhn A. Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations. Eur J Neurosci. 2012 Sep;36(5):2650-60. doi: 10.1111/j.1460-9568.2012.08184.x. Epub 2012 Jun 15.

82.

Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V. Development and Validation of a Fluorescence-based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers. Comb Chem High Throughput Screen. 2012 Jun 1;15(5):372-85.

81.

Korte M, Herrmann U, Zhang X, Draguhn A. The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Exp Brain Res. 2012 Apr;217(3-4):435-40. Epub 2011 Oct 18.

80.

Reichinnek S, von Kameke A, Hagenston AM, Freitag E, Roth FC, Bading H, Hasan MT, Draguhn A, Both M. Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro. Neuroimage. 2012 Mar;60(1):139-152.

79.

Roth FC, Draguhn A. GABA Metabolism and Transport: Effects on Synaptic Efficacy. Neural Plast. 2012;2012:805830. Epub 2012 Feb 23.

78.

Scheffzük C, Kukushka VI, Vyssotski AL, Draguhn A, Tort AB, Brankačk J. Selective Coupling between Theta Phase and Neocortical Fast Gamma Oscillations during REM-Sleep in Mice. PLoS One. 2011;6(12):e28489. Epub 2011 Dec 5.

77.

Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A. Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E607-16. Epub 2011 Jul 18.

76.

Reichinnek S, Künsting T, Draguhn A, Both M. Field potential signature of distinct multicellular activity patterns in the mouse hippocampus. J Neurosci. 2010 Nov 17;30(46):15441-9.

75.

Holter NI, Zylla MM, Zuber N, Bruehl C, Draguhn A. Tonic GABAergic control of mouse dentate granule cells during postnatal development. Eur J Neurosci. 2010 Oct;32(8):1300-9.;doi: 10.1111/j.1460-9568.2010.07331.x. Epub 2010 Sep 16.

74.

Schweizer PA, Duhme N, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M. cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control. Circ Arrhythm Electrophysiol. 2010 Oct 1;3(5):542-52. Epub 2010 Aug 7.

73.

Birke G, Draguhn A. No simple brake--the complex functions of inhibitory synapses. Pharmacopsychiatry. 2010 May;43 Suppl 1:S21-31. Epub 2010 May 17. Review.

72.

Zlomuzica A, Reichinnek S, Maxeiner S, Both M, May E, Wörsdörfer P, Draguhn A, Willecke K, Dere E. Deletion of connexin45 in mouse neurons disrupts one-trial object recognition and alters kainate-induced gamma-oscillations in the hippocampus. Physiol Behav. 2010 Sep 1;101(2):245-53. Epub 2010 May 21.

71.

Brankack J, Kukushka VI, Vyssotski AL, Draguhn A. EEG gamma frequency and sleep-wake scoring in mice: comparing two types of supervised classifiers. Brain Res. 2010 Mar 31;1322:59-71. Epub 2010 Feb 1.

70.

Bertsche A, Bruehl C, Pietz J, Draguhn A. Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices. Epilepsy Res. 2010 Feb;88(2-3):118-26. Epub 2009 Nov 24.

69.

Draguhn A, Both M. Dancing neurons, complex beats. J Physiol. 2009 Nov 15;587(Pt 22):5297. Review.

68.

Hermann D, Both M, Ebert U, Gross G, Schoemaker H, Draguhn A, Wicke K, Nimmrich V. Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes. Neuroscience. 2009 Sep 15;162(4):1081-90. Epub 2009 May 27.

67.

Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol. 2009 Jun;11(6):705-16. Epub 2009 May 24.

66.

Axmacher N, Draguhn A, Elger CE, Fell J. Memory processes during sleep: beyond the standard consolidation theory. Cell Mol Life Sci. 2009 Jul;66(14):2285-97. Epub 2009 Mar 26. Review.

65.

Lopantsev V, Both M, Draguhn A. Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges. Eur J Neurosci. 2009 Mar;29(6):1153-64.

64.

Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just WW. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Hum Mol Genet. 2009 Jun 1;18(11):1897-908. Epub 2009 Mar 8.

63.

Hartmann K, Bruehl C, Golovko T, Draguhn A. Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling. PLoS One. 2008 Aug 20;3(8):e2979.

62.

Kolbaev S, Draguhn A. Glutamine-induced membrane currents in cultured rat hippocampal neurons. Eur J Neurosci. 2008 Aug;28(3):535-45.

61.

Grimm C, Holter NI, Draguhn A, Bruehl C.; Compensatory increase in P/Q-calcium current-mediated synaptic transmission following chronic block of N-type channels. Neurosci Lett. 2008 Sep 5;442(1):44-9. Epub 2008 Jun 27.

60.

Both M, Bähner F, von Bohlen und Halbach O, Draguhn A. Propagation of specific network patterns through the mouse hippocampus. Hippocampus. 2008;18(9):899-908.

59.

Weiss EK, Krupka N, Bähner F, Both M, Draguhn A. Fast effects of glucocorticoids on memory-related network oscillations in the mouse hippocampus. J Neuroendocrinol. 2008 May;20(5):549-57. Epub 2008 Mar 15.

58.

Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C. Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci. 2008 Jan 23;28(4):788-97.

57.

Kreuzberg MM, Deuchars J, Weiss E, Schober A, Sonntag S, Wellershaus K, Draguhn A, Willecke K. Expression of connexin30.2 in interneurons of the central nervous system in the mouse. Mol Cell Neurosci. 2008 Jan;37(1):119-34. Epub 2007 Sep 12.

56.

Draguhn A, Axmacher N, Kolbaev S. Presynaptic ionotropic GABA receptors. Results Probl Cell Differ. 2008;44:69-85. Review.

55.

Holter NI, Zuber N, Bruehl C, Draguhn A. Functional maturation of developing interneurons in the molecular layer of mouse dentate gyrus. Brain Res. 2007 Dec;1186:56-64. Epub 2007 Oct 12.

54.

Stief F, Zuschratter W, Hartmann K, Schmitz D, Draguhn A. Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsy. Eur J Neurosci. 2007 Jan;25(2):519-28.

53.

Stief F, Piechotta A, Gabriel S, Schmitz D, Draguhn A. Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats. Epilepsy Res. 2005 Aug-Sep;66(1-3):199-202.

52.

Nimmrich V, Maier N, Schmitz D, Draguhn A. Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices. J Physiol. 2005 Mar 15;563(Pt 3):663-70. Epub 2005 Jan 20.

51.

Kozhemiakin MB, Draguhn A, Skrebitsky VG. Layer-specific potentiation of evoked IPSCs in rat hippocampal CA1 pyramidal cells by lanthanum. Brain Res Bull. 2004 Aug 30;64(2):97-101.

50.

Hartmann K, Stief F, Draguhn A, Frahm C. Ionotropic GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors. Eur J Pharmacol. 2004 Aug 23;497(2):139-46.

49.

Buzsáki G, Draguhn A. Neuronal oscillations in cortical networks. Science. 2004 Jun 25;304(5679):1926-9. Review.

48.

Axmacher N, Winterer J, Stanton PK, Draguhn A, Müller W. Two-photon imaging of spontaneous vesicular release in acute brain slices and its modulation by presynaptic GABAA receptors. Neuroimage. 2004 Jun;22(2):1014-21.

47.

Axmacher N, Draguhn A. Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3. Neuroreport. 2004 Feb 9;15(2):329-34.

46.

Axmacher N, Stemmler M, Engel D, Draguhn A, Ritz R. Transmitter metabolism as a mechanism of synaptic plasticity: a modeling study. J Neurophysiol. 2004 Jan;91(1):25-39. Epub 2003 Sep 17.

45.

Maier N, Nimmrich V, Draguhn A. Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices. J Physiol. 2003 Aug 1;550(Pt 3):873-87. Epub 2003 Jun 13.

44.

Frahm C, Stief F, Zuschratter W, Draguhn A. Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus. Epilepsy Res. 2003 Jan;52(3):243-52.

43.

Pöschel B, Heinemann U, Draguhn A. High frequency oscillations in the dentate gyrus of rat hippocampal slices induced by tetanic stimulation. Brain Res. 2003 Jan 10;959(2):320-7.

42.

Draguhn A, Hartmann K, Stief F, Frahm C, and Engel D: Transmitter-Konzentration und synaptische Hemmung bei Epilepsie. Z Epileptol 16:223-228, 2003.

41.

Vreugdenhil M, Hack SP, Draguhn A, Jefferys JG. Tetanus toxin induces long-term changes in excitation and inhibition in the rat hippocampal CA1 area. Neuroscience. 2002;114(4):983-94.

40.

Maier N, Güldenagel M, Söhl G, Siegmund H, Willecke K, Draguhn A. Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice. J Physiol. 2002 Jun 1;541(Pt 2):521-8.

39.

Pöschel B, Draguhn A, Heinemann U. Glutamate-induced gamma oscillations in the dentate gyrus of rat hippocampal slices. Brain Res. 2002 May 31;938(1-2):22-8.

38.

Traub RD, Draguhn A, Whittington MA, Baldeweg T, Bibbig A, Buhl EH, Schmitz D. Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis. Rev Neurosci. 2002;13(1):1-30. Review.

37.

Frahm C, Draguhn A. GAD and GABA transporter (GAT-1) mRNA expression in the developing rat hippocampus. Brain Res Dev Brain Res. 2001 Dec 14;132(1):1-13.

36.

Hinz B, Becher A, Mitter D, Schulze K, Heinemann U, Draguhn A, Ahnert-Hilger G. Activity-dependent changes of the presynaptic synaptophysin-synaptobrevin complex in adult rat brain. Eur J Cell Biol. 2001 Oct;80(10):615-9.

35.

Schmitz D, Schuchmann S, Fisahn A, Draguhn A, Buhl EH, Petrasch-Parwez E, Dermietzel R, Heinemann U, Traub RD. Axo-axonal coupling. A novel mechanism for ultrafast neuronal communication. Neuron. 2001 Sep 13;31(5):831-40.

34.

Engel D, Pahner I, Schulze K, Frahm C, Jarry H, Ahnert-Hilger G, Draguhn A. Plasticity of rat central inhibitory synapses through GABA metabolism. J Physiol. 2001 Sep 1;535(Pt 2):473-82.

33.

Frahm C, Engel D, Draguhn A. Efficacy of background GABA uptake in rat hippocampal slices. Neuroreport. 2001 Jun 13;12(8):1593-6.

32.

Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA, Bösl MR, Ruether K, Jahn H, Draguhn A, Jahn R, Jentsch TJ. Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron. 2001 Jan;29(1):185-96.

31.

Draguhn A, Traub RD, Bibbig A, Schmitz D. Ripple (approximately 200-Hz) oscillations in temporal structures. J Clin Neurophysiol. 2000 Jul;17(4):361-76. Review.

30.

Frahm C, Engel D, Piechotta A, Heinemann U, Draguhn A. Presence of gamma-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus. Neurosci Lett. 2000 Jul 21;288(3):175-8.

29.

Engel D, Endermann U, Frahm C, Heinemann U, Draguhn A. Acute effects of gamma-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro. Epilepsy Res. 2000 Jul;40(2-3):99-107.

28.

Grosse G, Draguhn A, Höhne L, Tapp R, Veh RW, Ahnert-Hilger G. Expression of Kv1 potassium channels in mouse hippocampal primary cultures: development and activity-dependent regulation. J Neurosci. 2000 Mar 1;20(5):1869-82.

27.

Meierkord H, Grünig F, Gutschmidt U, Gutierrez R, Pfeiffer M, Draguhn A, Brückner C, Heinemann U. Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):25-32.

26.

Sabau A, Frahm C, Pfeiffer M, Breustedt J, Piechotta A, Numberger M, Engel D, Heinemann U, Draguhn A. Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro. Eur J Pharmacol. 1999 Nov 3;383(3):259-66.

25.

Traub RD, Schmitz D, Jefferys JG, Draguhn A. High-frequency population oscillations are predicted to occur in hippocampal pyramidal neuronal networks interconnected by axoaxonal gap junctions. Neuroscience. 1999;92(2):407-26.

24.

Engel D, Schmitz D, Gloveli T, Frahm C, Heinemann U, Draguhn A. Laminar difference in GABA uptake and GAT-1 expression in rat CA1. J Physiol. 1998 Nov 1;512 ( Pt 3):643-9.

23.

Draguhn A, Traub RD, Schmitz D, Jefferys JG. Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature. 1998 Jul 9;394(6689):189-92.

22.

Schmitz D, Gloveli T, Empson RM, Draguhn A, Heinemann U. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. J Physiol. 1998 Apr 1;508 ( Pt 1):119-29.

21.

Draguhn A, Pfeiffer M, Heinemann U, Polder R. A simple hardware model for the direct observation of voltage-clamp performance under realistic conditions. J Neurosci Methods. 1997 Dec 30;78(1-2):105-13.

20.

Draguhn A, Börner G, Beckmann R, Buchner K, Heinemann U, Hucho F. Large-conductance cation channels in the envelope of nuclei from rat cerebral cortex. J Membr Biol. 1997 Jul 15;158(2):159-66.

19.

Bering R, Draguhn A, Diemer NH, Johansen FF. Ischemia changes the coexpression of somatostatin and neuropeptide Y in hippocampal interneurons. Exp Brain Res. 1997 Jul;115(3):423-9.

18.

Draguhn A, Jungclaus M, Sokolowa S, Heinemann U. Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons. Eur J Pharmacol. 1997 May 1;325(2-3):245-51.

17.

Draguhn A, Heinemann U. Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells. J Neurophysiol. 1996 Dec;76(6):3983-93.

16.

Colling SB, Man WD, Draguhn A, Jefferys JG. Dendritic shrinkage and dye-coupling between rat hippocampal CA1 pyramidal cells in the tetanus toxin model of epilepsy. Brain Res. 1996 Nov 25;741(1-2):38-43.

15.

Pfeiffer M, Draguhn A, Meierkord H, Heinemann U. Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. Br J Pharmacol. 1996 Oct;119(3):569-77.

14.

Bering R, Diemer NH, Draguhn A, Johansen FF. Co-localization of somatostatin mRNA and parvalbumin in the dorsal rat hippocampus after cerebral ischemia. Hippocampus. 1995;5(4):341-8.

13.

Heinemann U, Dreier J, Leschinger A, Stabel J, Draguhn A, Zhang C. Effects of anticonvulsant drugs on hippocampal neurons. Hippocampus. 1994 Jun;4(3):291-6. Review.

12.

Heinemann U, Draguhn A, Ficker E, Stabel J, Zhang CL. Strategies for the development of drugs for pharmacoresistant epilepsies. Epilepsia. 1994;35 Suppl 5:S10-21. Review.

11.

von Haebler D, Stabel J, Draguhn A, Heinemann U. Properties of horizontal cells transiently appearing in the rat dentate gyrus during ontogenesis. Exp Brain Res. 1993;94(1):33-42.

10.

Draguhn A, Jahn W, Witzemann V. Argiotoxin636 inhibits NMDA-activated ion channels expressed in Xenopus oocytes. Neurosci Lett. 1991 Nov 11;132(2):187-90.

9.

Draguhn A, Verdorn TA, Ewert M, Seeburg PH, Sakmann B. Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. Neuron. 1990 Dec;5(6):781-8.

8.

Ymer S, Draguhn A, Wisden W, Werner P, Keinänen K, Schofield PR, Sprengel R, Pritchett DB, Seeburg PH. Structural and functional characterization of the gamma 1 subunit of GABAA/benzodiazepine receptors. EMBO J. 1990 Oct;9(10):3261-7.

7.

Malherbe P, Draguhn A, Multhaup G, Beyreuther K, Möhler H. GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. Brain Res Mol Brain Res. 1990 Aug;8(3):199-208.

6.

Verdoorn TA, Draguhn A, Ymer S, Seeburg PH, Sakmann B. Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron. 1990 Jun;4(6):919-28.

5.

Mohler H, Malherbe P, Draguhn A, Richards JG. GABAA-receptors: structural requirements and sites of gene expression in mammalian brain. Neurochem Res. 1990 Feb;15(2):199-207. Review.

4.

Irintchev A, Draguhn A, Wernig A. Reinnervation and recovery of mouse soleus muscle after long-term denervation. Neuroscience. 1990;39(1):231-43.

3.

Mohler H, Malherbe P, Draguhn A, Sigel E, Sequier JM, Persohn E, Richards JG. GABAA-receptor subunits: functional expression and gene localisation. Adv Biochem Psychopharmacol. 1990;46:23-34. Review.

2.

Ymer S, Draguhn A, Köhler M, Schofield PR, Seeburg PH. Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Lett. 1989 Nov 20;258(1):119-22.

1.

Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 1989 Jun;8(6):1665-70.

Übersichtsarbeiten in Journalen mit Peer Review, Journal Supplements oder Büchern; Buchbeiträge und Bücher

15.

Hefter D, Draguhn A. APP as a Protective Factor in Acute Neuronal Insults. Front Mol Neurosci. 2017 Feb 2;10:22. doi: 10.3389/fnmol.2017.00022. eCollection 2017

14.

Kotchoubey B, Tretter F, Braun HA, Buchheim T, Draguhn A, Fuchs T, Hasler F, Hastedt H, Hinterberger T, Northoff G, Rentschler I, Schleim S, Sellmaier S, Tebartz Van Elst L, Tschacher W. Methodological Problems on the Way to Integrative Human Neuroscience. Front Integr Neurosci. 2016 Nov 29;10:41. eCollection 2016.

13.

Nimmrich V, Draguhn A, Axmacher N. Neuronal Network Oscillations in Neurodegenerative Diseases. 2015 Sep;17(3):270-84. doi: 10.1007/s12017-015-8355-9. Epub 2015 Apr 29.

12.

Draguhn, A. Geschmack und Geruch. In: Physiologie. H.-C. Pape, A. Kurtz and S. Silbernagl (Eds.) Georg Thieme Verlag, Stuttgart. 2014. pp. 805-818. ISBN 9783137960072

11.

Draguhn, A. Signalübertragung in Zellverbänden. In: Physiologie. H.-C. Pape, A. Kurtz and S. Silbernagl (Eds.) Georg Thieme Verlag, Stuttgart. 2014. pp. 86-131. ISBN 9783137960072

10.

Kann O, Papageorgiou IE, Draguhn A. Highly energized inhibitory interneurons are a central element for information processing in cortical networks. J Cereb Blood Flow Metab. 2014 Aug;34(8):1270-82. doi: 10.1038/jcbfm.2014.104. Epub 2014 Jun 4.

9.

Draguhn A, Keller M, Reichinnek S. Coordinated network activity in the hippocampus. Front Neurol Neurosci. 2014;34:26-35. doi: 10.1159/000357026. Epub 2014 Apr 16.

8.

Birke, G., D. Schmitz, A. Draguhn. (2010). Electrical Coupling of Axons. In: "New Aspects of Axonal Structure and Function". F. Dirk and J. H. R. Lübke. Berlin, Springer: 85-102.

7.

Draguhn, A. (2010). Einführung: Experimentell-biologische Zugänge der kognitiven Neurowissenschaften. In: "Verantwortlichkeit - nur eine Illusion?". T. Fuchs and G. Schwarzkopf. Heidelberg, Universitätsverlag Winter: 107-125

6.

Draguhn, A. (2010). Geschmack und Geruch. In: "Physiologie". R. Klinke, H.-C. Pape, A. Kurtz and S. Silbernagl. Stuttgart, Georg Thieme Verlag: 742-755.

5.

Draguhn, A. (2010). Membranpotenzial und Signalübertragung in Zellverbänden. In: "Physiologie". R. Klinke, H.-C. Pape, A. Kurtz and S. Silbernagl. Stuttgart, Georg Thieme Verlag: 60-95.

4.

Draguhn, A., N. Axmacher, et al. (2008). Presynaptic Ionotropic GABA Receptors. In: "Inhibitory Regulation of Excitatory Neurotransmission". M. G. Darlison. Berlin, Springer Verlag: 69-85.

3.

Draguhn, A. and K. Hartmann (2007). GABAergic Synaptic Transmission. In: "Chloride Movements Across Cellular Membranes". M. Pusch, Elsevier Ltd. 38: 215-240.

2.

Draguhn, A. (2004). Willensfreiheit und Gehirn. In: "Das Selbst in der Evolution". W. Härle and R. Preul. Marburg, N.G. Elwert Verlag: 79-110.

1.

Numberger M, and Draguhn A. Patch-Clamp-Technik, Heidelberg, Berlin, Oxford: Spektrum Akad. Verlag, 1996.


Neue Publikationen

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Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes. Anal Bioanal Chem. 2017 Nov 16. doi: 10.1007/s00216-017-0748-1. [Epub ahead of print]

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Role of protein carbonylation in diabetes. J Inherit Metab Dis. 2017 Nov 6. doi: 10.1007/s10545-017-0104-9. [Epub ahead of print]

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AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15; 9: 69–79. Epub 2017 Sep 20. doi: 10.1016/j.omtn.2017.08.014

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Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.

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Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

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Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus. J Cereb Blood Flow Metab. 2017 Nov 3; 271678X17740091. doi: 10.1177/0271678X17740091

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Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

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Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8

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NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.


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