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Institute of Physiology and Pathophysiology

Research Areas

The Drews Group aims at elucidating whether specific components of the ubiquitin-proteasome system have the potential to interfere with the pathogenesis of cardiovascular disease.

 

This group has been discontinued, effective 14 October 2017.

 

Contact:
Phone  +49 6221 54-4130
E-Mail  drews@physiologie.uni-heidelberg.de

The Hecker Group investigates the role of various signalling molecules in controlling the expression of mechanosensitive genes in vascular cells.

The Korff Group studies biomechanically induced remodeling processes in arterial and venous blood vessels.

Die Ullrich Group investigates, among other topics, the differentiation of stem cell-derived cardiomyocytes with particular focus on their electrophysiological properties.

The Wagner Group is interested in the role of the CD40/ CD154-mediated interaction between endothelial cells and leucocytes/ blood platelets in the early phase of chronic subacute inflammatory diseases.
Another focal point is the pathophysiological relevance of reactive oxygen species as signalling molecules in inflammatory remodelling processes in the vascular wall, in the early phase of arteriosclerosis and during the development of secondary complications in diabetes mellitus, respectively.

Scientists from the Division work on the development of novel DNA-based drugs, so-called decoy-oligonucleotides for the therapy of heart failure.


24.10.2017       13:30   /   INF 327, Seminar Room 1

 

Hypoxia and uterine contractions: Something old and something new

Prof. Dr. Susan Wray

Dept. of Cellular and Molecular Physiology, University of Liverpool, United Kingdom

  

24.10.2017       18:00   /   INF 410 (Med. Clinic), Auditorium

 

Calcium in the heart: in and out of control

Prof. Dr. David Eisner

Manchester Institute for Collaborative Research on Ageing, University of Manchester, United Kingdom


(seminar of Heidelberg University Hospital and German Center for Cardiovascular Disease (DZHK); host: Prof. Dr. M. Hecker, Inst. of Physiology and Pathophysiology, Heidelberg University)

  

Recent Publications

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AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15; 9: 69–79. Epub 2017 Sep 20. doi: 10.1016/j.omtn.2017.08.014

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Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.

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Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

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Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

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Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8

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NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de