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Institute of Physiology and Pathophysiology

Research Areas

The Hecker Working Group investigates the role of various signalling molecules in controlling the expression of mechanosensitive genes in vascular cells.

The Korff Working Group investigates mechanisms of (patho)physiological remodeling processes of arteries and veins.

Die Ullrich Working Group investigates, among other topics, the differentiation of stem cell-derived cardiomyocytes with particular focus on their electrophysiological properties.

The Wagner Working Group is interested in the role of the CD40/ CD154-mediated interaction between endothelial cells and leucocytes/ blood platelets in the early phase of chronic subacute inflammatory diseases.
Another focal point is the pathophysiological relevance of reactive oxygen species as signalling molecules in inflammatory remodelling processes in the vascular wall, in the early phase of arteriosclerosis and during the development of secondary complications in diabetes mellitus, respectively.

Scientists from the Division work on the development of novel DNA-based drugs, so-called decoy-oligonucleotides for the therapy of heart failure.


Recent Publications

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Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201813562. doi: 10.1073/pnas.1813562116. [Epub ahead of print]

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Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels. Cell Calcium. 2019 Mar;78:66-75. doi: 10.1016/j.ceca.2019.01.002. Epub 2019 Jan 9.

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EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Acta Neuropathol Commun. 2019 Feb 5;7(1):15. doi: 10.1186/s40478-019-0669-7.

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Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One. 2019 Jan 15;14(1):e0209228. doi: 10.1371/journal.pone.0209228. eCollection 2019.

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Medikamentöse Varikosetherapie aus der Perspektive experimenteller Modelle. Praxis (Bern 1994). 2019 Jan;108(1):31-36. doi: 10.1024/1661-8157/a003147.

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Selective vulnerability of αOFF retinal ganglion cells during onset of autoimmune optic neuritis. Neuroscience. 2018 Nov 21;393:258-272. doi: 10.1016/j.neuroscience.2018.07.040. Epub 2018 Aug 1.

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The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J2018 Nov;32(11):6159-6173. Epub 2018 Jun 7.

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Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2018 Nov 1:fj201801594R. doi: 10.1096/fj.201801594R. [Epub ahead of print]

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Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2018 Oct 23. doi: 10.1055/s-0038-1673633. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4035
Fax:+49 6221 54-4038
E-mail:sekretariat.hecker@
physiologie.uni-heidelberg.de