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Institute of Physiology and Pathophysiology

Korff Group

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Group Members

Endothelial Spheroids: An Advanced Replacement Model (3Rs principle)
for the Study of Endothelial Differentiation and Angiogenesis

about applications FAQ contact publications

Welcome to our web page specifically dedicated to an endothelial spheroid-based in vitro cell culture system developed in our group. Here we provide some general background on this technique as well as more detailed, up-to-date information for researchers already using this experimental approach in their groups.


Recent Publications

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Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice. IBRO Rep. 2020 Dec;9:195-206. doi: 10.1016/j.ibror.2020.08.001. eCollection 2020 Dec. Epub 2020 Aug 11.

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VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations. Neuroscience. 2020 Nov 10;448:28-42. doi: 10.1016/j.neuroscience.2020.09.012. Epub 2020 Sep 11.

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2020 Nov;40(11):2225-2239. doi: 10.1177/0271678X19887777. Epub 2019 Nov 13.

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Multifunctional reactive MALDI matrix enabling high-lateral resolution dual polarity MS imaging and lipid C=C position-resolved MS2 imaging. 2020 Oct 20;92(20):14130-14138. doi: 10.1021/acs.analchem.0c03150. Epub 2020 Sep 28.

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Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. J Neurosci Res. 2020 Oct;98(10):1953-1967. doi: 10.1002/jnr.24689. Epub 2020 Jul 7.

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Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns. Hippocampus. 2020 Oct;30(10):1044-1057. doi: 10.1002/hipo.23214. Epub 2020 May 15.

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Processing of hippocampal network activity in the receiver network of the medial entorhinal cortex layer V. J Neurosci. 2020 Sep 25:JN-RM-0586-20. doi: 10.1523/JNEUROSCI.0586-20.2020. Online ahead of print.

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Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2020 Sep 2. doi: 10.1007/s00709-020-01550-9. Online ahead of print.

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020 Sep;19(9):609-633. doi: 10.1038/s41573-020-0072-x. Epub 2020 Jul 24.

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Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2020 Aug 14;S1084-9521(19)30197-1. doi: 10.1016/j.semcdb.2020.08.001. Online ahead of print.

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GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ. J Neuroinflammation. 2020 Aug 11;17(1):235. doi: 10.1186/s12974-020-01903-4.

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Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

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Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun. 2020 Aug;88:802-814. doi: 10.1016/j.bbi.2020.05.052. Epub 2020 May 21.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de