Select languageSelect language
Institut für Physiologie und Pathophysiologie

Prof. Dr. rer. nat. Markus Hecker

Publikationsliste

Markierte Titel sind mit dem jeweiligen Abstract auf einer frei zugänglichen Webseite verlinkt.

Originalarbeiten in Journalen mit Peer Review

171.

Jäger M, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T. Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020 Mar 1;388(1):111782. doi: 10.1016/j.yexcr.2019.111782. Epub 2019 Dec 16.

170.

Silbernagel N, Körner A, Balitzki J, Jaggy M, Bertels S, Richter B, Hippler M, Hellwig A, Hecker M, Bastmeyer M, Ullrich ND. Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

169.

Remes A, Franz M, Mohr F, Weber A, Rapti K, Jungmann A, Karck M, Hecker M, Kallenbach K, Müller OJ, Arif R, Wagner AH. AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts. Mol Ther Methods Clin Dev. 2019 Dec 13;15:246-256. doi: 10.1016/j.omtm.2019.09.009. eCollection 2019 Dec 13. Epub 2019 Oct 2.

168.

Jiang F, Mohr F, Ullrich ND, Hecker M, Wagner AH. Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

167.

Arif R, Franz M, Remes A, Zaradzki M, Hecker M, Karck M, Müller OJ, Kallenbach K, Wagner AH. Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

166.

Sultan CS, Weitnauer M, Turinsky M, Kessler T, Brune M, Gleissner CA, Leuschner F, Wagner AH, Hecker M. Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]

165.

Urban I, Turinsky M, Gehrmann S, Morgenstern J, Brune M, Milewski MR, Wagner AH, Rumig C, Fleming TH, Leuschner F, Gleissner CA, Hecker M. 15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells with a Genetically Determined Nitric Oxide Deficit. Circ Res. 2019 Jul 19;125(3):282-294. doi: 10.1161/CIRCRESAHA.118.313820. Epub 2019 Jun 19.

164.

Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T. Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2019 Mar;33(3):3364-3377. doi: 10.1096/fj.201801594R. Epub 2018 Nov 1.

163.

Ernst AS, Böhler LI, Hagenston AM, Hoffmann A, Heiland S, Sticht C, Bendszus M, Hecker M, Bading H, Marti HH, Korff T, Kunze R. EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Acta Neuropathol Commun. 2019 Feb 5;7(1):15. doi: 10.1186/s40478-019-0669-7.

162.

Khamehgir-Silz P, Schnitter F, Wagner AH, Gerbig S, Schulz S, Hecker M, Spengler B. Strategy for marker-based differentiation of pro- and anti-inflammatory macrophages using matrix-assisted laser desorption/ionization mass spectrometry imaging. Analyst. 2018 Sep 10;143(18):4273-4282. doi: 10.1039/c8an00659h. Epub 2018 Jul 20.

161.

Zappe M, Feldner A, Arnold C, Sticht C, Hecker M, Korff T. NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol. 2018 Aug 23;9:1190. doi: 10.3389/fphys.2018.01190. eCollection 2018.

160.

Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND. Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol. 2018 Jul;120:31-41. doi: 10.1016/j.yjmcc.2018.05.010. Epub 2018 May 16.

159.

Popa M, Tahir S, Elrod J, Kim SH, Leuschner F, Kessler T, Bugert P, Pohl U, Wagner AH, Hecker M. Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5556-E5565. doi: 10.1073/pnas.1801366115. Epub 2018 May 23.

158.

Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH. Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1.

157.

Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T. Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol. 2018 Apr 4;9:320. doi: 10.3389/fphys.2018.00320. eCollection 2018.

156.

Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2018 Apr;32(4):2021-2035. doi: 10.1096/fj.201700384RR. Epub 2018 Jan 5.

155.

Weigand T, Singler B, Fleming T, Nawroth P, Klika KD, Thiel C, Baelde H, Garbade SF, Wagner AH, Hecker M, Yard BA, Amberger A, Zschocke J, Schmitt CP, Peters V. Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal. Cell Physiol Biochem. 2018;46(2):713-726. doi: 10.1159/000488727. Epub 2018 Mar 29.

154.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M. Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.

153.

Morgenstern J, Fleming T, Kadiyska I, Brings S, Groener JB, Nawroth P, Hecker M, Brune M. Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes. Anal Bioanal Chem. 2018 Jan;410(2):521-528. doi: 10.1007/s00216-017-0748-1. Epub 2017 Nov 16.

152.

Kuk H, Arnold C, Meyer R, Hecker M, Korff T. Magnolol inhibits venous remodeling in mice. Sci Rep. 2017 Dec 19;7(1):17820. doi: 10.1038/s41598-017-17910-0.

151.

Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K. AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.

150.

Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.

149.

Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovasc Res. 2017 May 1;113(6):681-691. doi: 10.1093/cvr/cvx032.

148.

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. 2017 Mar 13;31(3):355-367. doi: 10.1016/j.ccell.2017.01.007. Epub 2017 Feb 23.

147.

Abbas M, Jesel L, Auger C, Amoura LK, Messas N, Manin G, Rumig C, León-González AJ, Ribeiro TP, Silva GC, Abou-Merhi R, Hamade E, Hecker M, Georg Y, Chakfe N, Ohlmann P, Schini-Kerth VB, Toti F, Morel O. Endothelial Microparticles from Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cells Ageing and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-mediated Activation of MAPKs and PI3-kinase Pathways. Circulation. 2017 Jan 17;135(3):280-296. doi: 10.1161/CIRCULATIONAHA.116.017513.

146.

Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T. Varicose Remodeling of Veins Is Suppressed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors. J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002405. doi: 10.1161/JAHA.115.002405.

145.

Schröder H, Komljenovic D, Hecker M, Korff T. Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle. FASEB J. 2016 Feb;30(2):923-32. doi: 10.1096/fj.15-279240. Epub 2015 Nov 6.

144.

Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Carnosine metabolism in diabetes is altered by reactive metabolites. Amino Acids. 2015 Nov;47(11):2367-2376. Epub 2015 Jun 17.

143.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J Mol Cell Cardiol. 2015 Nov;88:111-9. doi: 10.1016/j.yjmcc.2015.10.009. Epub 2015 Oct 9.

142.

Löffers C, Heilig B, Hecker M. T-786C single nucleotide polymorphism of the endothelial nitric oxide synthase gene as a risk factor for endothelial dysfunction in polymyalgia rheumatica. Clin Exp Rheumatol. 2015 Sep-Oct;33(5):726-30. Epub 2015 Aug 27.

141.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T. Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 2015 Jul;29(7):3076-84. doi: 10.1096/fj.14-267633. Epub 2015 Apr 9.

140.

Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M. Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells. J Am Heart Assoc. 2015 Jun 12;4(6). pii: e001712.

139.

Wagner AH, Conzelmann M, Fitzer F, Giese T, Gülow K, Falk CS, Krämer OH, Dietrich S, Hecker M, Luft T. JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter. Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.

138.

Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-Valdes N, Umansky V, Schneider SW. von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood. 2015 May 14;125(20):3153-63. doi: 10.1182/blood-2014-08-595686. Epub 2015 Feb 24.

137.

Möller K, Adolph O, Grünow J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C, Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH, Hecker M. Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells. Thromb Haemost. 2015 May;113(5):1095-108. doi: 10.1160/TH14-04-0336. Epub 2015 Jan 22.

136.

Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M. daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans. Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17.

135.

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T. TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells. Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014.

134.

Wagner AH, Schwarz M, König G, Hecker M. Role of platelet CD40 ligand for endothelial cell-monocyte interaction in the presence of flow. Korea-Aust Rheol J. 2014 Nov;26(4):405-8.

133.

Pfisterer L, Meyer R, Feldner A, Drews O, Hecker M, Korff T. Bortezomib protects from varicose-like venous remodeling. FASEB J. 2014 Aug;28(8):3518-27. doi: 10.1096/fj.14-250464. Epub 2014 Apr 25.

132.

Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T. EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. Thromb Haemost. 2014 Jul 3;112(1):151-63. doi: 10.1160/TH13-12-1034. Epub 2014 Feb 13.

131.

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T. RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med. 2014 Jun 27;6(8):1075-89. doi: 10.15252/emmm.201403864.

130.

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T. Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc. 2014 Mar 10;3(2):e000626. doi: 10.1161/​JAHA.113.000626.

129.

Schröder HM, Hoffmann S, Hecker M, Korff T, Ludwig T. The tetraspanin network modulates MT1-MMP cell surface trafficking. Int J Biochem Cell Biol. Int J Biochem Cell Biol. 2013 Jun;45(6):1133-44. doi: 10.1016/j.biocel.2013.02.020. Epub 2013 Mar 14.

128.

Djuric Z, Muhammed K, Fleming T, Murikinati S, Piel D, von Bauer R, Bea F, Herzig S,  Zeier M, Liou HC, Pizzi M, Isermann B, Hecker M, Schwaninger M, Bierhaus A, Nawroth PP. Targeting NFκB subunit-specific activation prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012;18:1375-86. doi: 10.2119/molmed.2012.00282.

127.

Babu SS, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal. 2012 Dec 11;5(254):ra91 doi: 10.1126/scisignal.2003173

126.

Cattaruzza M, Nogoy N, Wojtowicz A, Hecker M. Zinc finger motif-1 antagonizes PDGF-BB-induced growth and dedifferentiation of vascular smooth muscle cells. FASEB J. 2012 Dec;26(12):4864-75. Epub 2012 Aug 20.

125.

Pfisterer L, Feldner A, Hecker, M, Korff T. Hypertension impairs myocardin function - a novel mechanism facilitating arterial remodeling. Cardiovasc Res. 2012 Oct 1;96(1):120-9. Epub 2012 Jul 26.

124.

Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ. Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Ther. 2012 Aug;19(8):800-9. Epub 2011 Sep 29.

123.

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M. Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

122.

Feldner A, Otto H, Rewerk S, Hecker M, Korff T. Experimental hypertension triggers varicosis-like maladaptive venous remodeling through activator protein-1. FASEB J. 2011 Oct;25(10):3613-21. Epub 2011 Jun 17.

121.

Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M. Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells. Blood. 2011 Sep 29;118(13):3734-42. Epub 2011 Aug 10.

120.

Hoffmann S, Hosseini BH, Hecker M, Louban I, Bulbuc N, Garbi N, Wabnitz GH, Samstag Y, Spatz JP, Hämmerling GJ. Single cell force spectroscopy of T cells recognizing a myelin-derived peptide on antigen presenting cells.  Immunol Lett. 2011 Apr 30;136(1):13-20. Epub 2010 Nov 26.

119.

Braun J, Hoffmann SC, Feldner A, Ludwig T, Henning R, Hecker M, Korff T. Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):297-305. Epub 2010 Dec 2.

118.

Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T. IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. Epub 2010 Aug 13.

117.

Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M. Zyxin mediation of stretch-induced gene expression in human endothelial cells. Circ Res. 2010 Oct 1;107(7):898-902. Epub 2010 Aug 12. Erratum in: Circ Res.2010 Oct 29;107(9):e15-6.

116.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M. Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 2010 Jul 1;120(7):2307-18. Epub 2010 Jun 14.

115.

Lührmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner AH. Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. Exp Lung Res. 2010 Mar;36(2):85-93.

114.

Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Güldenzoph B, Bermejo JL, Korff T, Hecker M. Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1894-901. Epub 2009 Sep 3.

113.

Asif AR, Hecker M, Cattaruzza M. Disinhibition of SOD-2 expression to compensate for a genetically determined NO deficit in endothelial cells--brief report. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1890-3. Epub 2009 Aug 20.

112.

Stojanovic T, Wagner AH, Wang S, Kiss E, Rockstroh N, Bedke J, Gröne HJ, Hecker M. STAT-1 decoy oligodeoxynucleotide inhibition of acute rejection in mouse heart transplants. Basic Res Cardiol. 2009 Nov;104(6):719-29. Epub 2009 Apr 8.

111.

Asif AR, Oellerich M, Armstrong VW, Hecker M, Cattaruzza M. T-786C polymorphism of the NOS-3 gene and the endothelial cell response to fluid shear stress-a proteome analysis.J Proteome Res. 2009 Jun;8(6):3161-8.

110.

Zerr-Fouineau M, Jourdain M, Boesch C, Hecker M, Bronner C, Schini-Kerth VB. Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):586-93. Epub 2008 Dec 18.

109.

Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, Korff T, Hecker M, Augustin HG. Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. J Cell Sci. 2008 Nov 15;121(Pt 22):3842-50. Epub 2008 Oct 28.

108.

Stadlbauer TH, Wagner AH, Hölschermann H, Fiedel S, Fingerhuth H, Tillmanns H, Bohle RM, Hecker M. AP-1 and STAT-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts. Cardiovasc Res. 2008 Sep 1;79(4):698-705. Epub 2008 May 29.

107.

Demicheva E, Hecker M, Korff T. Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis. Circ Res. 2008 Aug 29;103(5):477-84. Epub 2008 Jul 31.

106.

Morawietz H, Wagner AH, Hecker M, Goettsch W. Endothelin receptor B-mediated induction of c-jun and AP-1 in response to shear stress in human endothelial cells. Can J Physiol Pharmacol. 2008 Aug;86(8):499-504.

105.

Korff T, Braun J, Pfaff D, Augustin HG, Hecker M. Role of ephrinB2 expression in endothelial cells during arteriogenesis: impact on smooth muscle cell migration and monocyte recruitment. Blood. 2008 Jul 1;112(1):73-81. Epub 2008 Apr 29.

104.

Wagner AH, Wittjen I, Stojanovic T, Middel P, Meingassner JG, Hecker M. Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity. J Allergy Clin Immunol. 2008 Jan;121(1):158-165.e5. Epub 2007 Nov 5.

103.

Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response. Circulation. 2007 Nov 13;116(20):2288-97. Epub 2007 Oct 29.

102.

Stojakovic M, Krzesz R, Wagner AH, Hecker M. CD154-stimulated GM-CSF release by vascular smooth muscle cells elicits monocyte activation--role in atherogenesis. J Mol Med. 2007 Nov;85(11):1229-38. Epub 2007 Jul 10.

101.

Stojanovic T, Scheele L, Wagner AH, Middel P, Bedke J, Lautenschläger I, Leister I, Panzner S, Hecker M. STAT-1 decoy oligonucleotide improves microcirculation and reduces acute rejection in allogeneic rat small bowel transplants. Gene Ther. 2007 Jun;14(11):883-90. Epub 2007 Mar 15.

100.

Hückel M, Schurigt U, Wagner AH, Stöckigt R, Petrow PK, Thoss K, Gajda M, Henzgen S, Hecker M, Bräuer R. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther. 2006;8(1):R17.

99.

Melchers I, Blaschke S, Hecker M, Cattaruzza M. The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis. Arthritis Rheum. 2006 Oct;54(10):3144-51.

98.

Kusch B, Waldhans S, Sattler A, Wagner A, Hecker M, Moosdorf R, Vogt S. Inhibition of carotis venous bypass graft disease by intraoperative nucleic acid-based therapy in rabbits. Thorac Cardiovasc Surg. 2006 Sep;54(6):388-92.

97.

Hölschermann H, Stadlbauer TH, Wagner AH, Fingerhuth H, Muth H, Rong S, Güler F, Tillmanns H, Hecker M. STAT-1 and AP-1 decoy oligonucleotide therapy delays acute rejection and prolongs cardiac allograft survival. Cardiovasc Res. 2006 Aug 1;71(3):527-36. Epub 2006 May 27.

96.

Hasselblatt M, Krampe H, Jacobs S, Sindram H, Armstrong VW, Hecker M, Ehrenreich H. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. Alcohol Alcohol. 2006 Jul-Aug;41(4):372-8.

95.

Gao D, Wagner AH, Fankhaenel S, Stojanovic T, Schweyer S, Panzner S, Hecker M. CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut. 2005 Jan;54(1):70-7.

94.

Cattaruzza M, Guzik TJ, SÅ‚odowski W, Pelvan A, Becker J, Halle M, Buchwald AB, Channon KM, Hecker M. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res. 2004 Oct 15;95(8):841-7. Epub 2004 Sep 16.

93.

Quarcoo D, Weixler S, Groneberg D, Joachim R, Ahrens B, Wagner AH, Hecker M, Hamelmann E. Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity. J Allergy Clin Immunol. 2004 Aug;114(2):288-95.

92.

Wagner AH, Güldenzoph B, Lienenlüke B, Hecker M. CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):715-20. Epub 2004 Feb 19.

91.

Cattaruzza M, Lattrich C, Hecker M. Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells. Hypertension. 2004 Apr;43(4):726-30. Epub 2004 Feb 16.

90.

Cattaruzza M, SÅ‚odowski W, Stojakovic M, Krzesz R, Hecker M. Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem. 2003 Sep 26;278(39):37874-80. Epub 2003 Jul 11.

89.

Schaeffer G, Levak-Frank S, Spitaler MM, Fleischhacker E, Esenabhalu VE, Wagner AH, Hecker M, Graier WF. Intercellular signalling within vascular cells under high D-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia. 2003 Jun;46(6):773-83. Epub 2003 Jun 13.

88.

Wagner AH, Gebauer M, Güldenzoph B, Hecker M. 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1784-9.

87.

Kelkenberg U, Wagner AH, Sarhaddar J, Hecker M, von der Leyen HE. CCAAT/enhancer-binding protein decoy oligodeoxynucleotide inhibition of macrophage-rich vascular lesion formation in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):949-54.

86.

Wagner AH, Schwabe O, Hecker M. Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. Br J Pharmacol. 2002 May;136(1):143-9.

85.

Schramm L, La M, Heidbreder E, Hecker M, Beckman JS, Lopau K, Zimmermann J, Rendl J, Reiners C, Winderl S, Wanner C, Schmidt HH. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. Kidney Int. 2002 Apr;61(4):1423-32.

84.

Buchwald AB, Wagner AH, Webel C, Hecker M. Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs. J Am Coll Cardiol. 2002 Feb 20;39(4):732-8.

83.

Cattaruzza M, Berger MM, Ochs M, Fayyazi A, Füzesi L, Richter J, Hecker M. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cell Death Differ. 2002 Feb;9(2):219-26.

82.

Stojanovic T, Bedke J, Gröne HJ, Proudfoot AE, Becker H, Markus P, Hecker M. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. J Vasc Res. 2002 Jan-Feb;39(1):51-8.

81.

Cattaruzza M, Schäfer K, Hecker M. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. J Biol Chem. 2002 Feb 22;277(8):6582-9. Epub 2001 Dec 17.

80.

Wagner AH, Gebauer M, Pollok-Kopp B, Hecker M. Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1. Blood. 2002 Jan 15;99(2):520-5.

79.

Wagner AH, Schroeter MR, Hecker M. 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 2001 Oct;15(12):2121-30.

78.

Cattaruzza M, Eberhardt I, Hecker M. Mechanosensitive transcription factors involved in endothelin B receptor expression. J Biol Chem. 2001 Oct 5;276(40):36999-7003. Epub 2001 Jul 16.

77.

Lienenlüke B, Stojanovic T, Fiebig T, Fayyazi A, Germann T, Hecker M. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. Br J Pharmacol. 2001 Aug;133(8):1414-23.

76.

Lauth M, Cattaruzza M, Hecker M. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):61-6.

75.

Lauth M, Wagner AH, Cattaruzza M, Orzechowski HD, Paul M, Hecker M. Transcriptional control of deformation-induced preproendothelin-1 gene expression in endothelial cells. J Mol Med. 2000;78(8):441-50.

74.

Wagner AH, Krzesz R, Gao D, Schroeder C, Cattaruzza M, Hecker M. Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells. Mol Pharmacol. 2000 Dec;58(6):1333-40.

73.

Schubert A, Cattaruzza M, Hecker M, Darmer D, Holtz J, Morawietz H. Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene. Circ Res. 2000 Dec 8;87(12):1188-94.

72.

Lienenlüke B, Germann T, Kroczek RA, Hecker M. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. Eur J Immunol. 2000 Oct;30(10):2864-70.

71.

Cattaruzza M, Dimigen C, Ehrenreich H, Hecker M. Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells. FASEB J. 2000 May;14(7):991-8.

70.

Cattaruzza M, Wachter R, Wagner AH, Hecker M. Modulation by dihydropyridine-type calcium channel antagonists of cytokine-inducible gene expression in vascular smooth muscle cells. Br J Pharmacol. 2000 Mar;129(6):1155-62.

69.

Lauth M, Berger MM, Cattaruzza M, Hecker M. Elevated perfusion pressure upregulates endothelin-1 and endothelin B receptor expression in the rabbit carotid artery. Hypertension. 2000 Feb;35(2):648-54.

68.

Lauth M, Berger MM, Cattaruzza M, Hecker M. Pressure-induced upregulation of preproendothelin-1 and endothelin B receptor expression in rabbit jugular vein in situ : implications for vein graft failure? Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):96-103.

67.

Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.

66.

Hattenbach LO, Allers A, Klais C, Koch F, Hecker M. L-Arginine-nitric oxide pathway-related metabolites in the aqueous humor of diabetic patients. Invest Ophthalmol Vis Sci. 2000 Jan;41(1):213-7.

65.

Krzesz R, Wagner AH, Cattaruzza M, Hecker M. Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappaB and signal transducer and activation of transcription-1. FEBS Lett. 1999 Jun 18;453(1-2):191-6.

64.

Kaw S, Hecker M. Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics. Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):133-9.

63.

Kessler P, Kronemann N, Hecker M, Busse R, Schini-Kerth VB. Effects of barbiturates on the expression of the inducible nitric oxide synthase in vascular smooth muscle. J Cardiovasc Pharmacol. 1997 Dec;30(6):802-10.

62.

Wigand R, Meyer J, Busse R, Hecker M. Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity. Ann Rheum Dis. 1997 May;56(5):330-2.

61.

Meyer J, Richter N, Hecker M. High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo. Anal Biochem. 1997 Apr 5;247(1):11-6. Erratum in: Analo Biochem 1998 Jun 15;260(1):114.

60.

Hecker M, Blaukat A, Bara AT, Müller-Esterl W, Busse R. ACE inhibitor potentiation of bradykinin-induced venoconstriction. Br J Pharmacol. 1997 Aug;121(7):1475-81.

59.

Hecker M, Preiss C, Schini-Kerth VB. Induction by staurosporine of nitric oxide synthase expression in vascular smooth muscle cells: role of NF-kappa B, CREB and C/EBP beta. Br J Pharmacol. 1997 Mar;120(6):1067-74.

58.

Popp R, Bauersachs J, Hecker M, Fleming I, Busse R. A transferable, beta-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells. J Physiol. 1996 Dec 15;497 ( Pt 3):699-709.

57.

Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation. 1996 Dec 15;94(12):3341-7.

56.

Hecker M, Preiss C, Klemm P, Busse R. Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kappa B and interferon regulatory factor 1. Br J Pharmacol. 1996 Aug;118(8):2178-84.

55.

Kessler P, Lischke V, Hecker M. Etomidate and thiopental inhibit the release of endothelium-derived hyperpolarizing factor in the human renal artery. Anesthesiology. 1996 Jun;84(6):1485-8.

54.

Ayajiki K, Kindermann M, Hecker M, Fleming I, Busse R. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ Res. 1996 May;78(5):750-8.

53.

Hecker M, Preiss C, Schini-Kerth VB, Busse R. Antioxidants differentially affect nuclear factor kappa B-mediated nitric oxide synthase expression in vascular smooth muscle cells. FEBS Lett. 1996 Feb 19;380(3):224-8. Erratum in: FEBS Lett 1996 Apr 29;385(1-2):124.

52.

Lischke V, Busse R, Hecker M. Volatile and intravenous anesthetics selectively attenuate the release of endothelium-derived hyperpolarizing factor elicited by bradykinin in the coronary microcirculation. Naunyn Schmiedebergs Arch Pharmacol. 1995 Sep;352(3):346-9.

51.

Lischke V, Busse R, Hecker M. Inhalation anesthetics inhibit the release of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Anesthesiology. 1995 Sep;83(3):574-82.

50.

Klemm P, Hecker M, Stockhausen H, Wu CC, Thiemermann C. Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. Br J Pharmacol. 1995 Aug;115(7):1175-81.

49.

Lischke V, Busse R, Hecker M. Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Br J Pharmacol. 1995 Jul;115(6):969-74.

48.

Hecker M, Boese M, Schini-Kerth VB, Mülsch A, Busse R. Characterization of the stable L-arginine-derived relaxing factor released from cytokine-stimulated vascular smooth muscle cells as an NG-hydroxyl-L-arginine-nitric oxide adduct. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4671-5.

47.

Hecker M, Vorhoff W, Bara AT, Mordvintcev PI, Busse R. Characterization of furoxans as a new class of tolerance-resistant nitrovasodilators. Naunyn Schmiedebergs Arch Pharmacol. 1995 Apr;351(4):426-32.

46.

Hecker M, Schott C, Bucher B, Busse R, Stoclet JC. Increase in serum NG-hydroxy-L-arginine in rats treated with bacterial lipopolysaccharide. Eur J Pharmacol. 1995 Feb 24;275(1):R1-3.

45.

Hecker M, Nematollahi H, Hey C, Busse R, Racké K. Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis. FEBS Lett. 1995 Feb 13;359(2-3):251-4.

44.

Bauersachs J, Hecker M, Busse R. Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br J Pharmacol. 1994 Dec;113(4):1548-53.

43.

Hecker M, Bara AT, Bauersachs J, Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol. 1994 Dec 1;481 ( Pt 2):407-14.

42.

Hecker M, Winter I, Busse R (1994): Inhibition of endothelial cell proliferation by calcium antagonists. Pharmacol. Commun. 4, 251-257.

41.

Fleming I, Hecker M, Busse R. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells. Circ Res. 1994 Jun;74(6):1220-6.

40.

Hecker M, Mülsch A, Busse R. Subcellular localization and characterization of neuronal nitric oxide synthase. J Neurochem. 1994 Apr;62(4):1524-9.

39.

Hecker M, Mülsch A, Bassenge E, Förstermann U, Busse R. Subcellular localization and characterization of neuronal nitric oxide synthase. Biochem J. 1994 Apr 1;299 ( Pt 1):247-52.

38.

Pörsti I, Bara AT, Busse R, Hecker M. Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br J Pharmacol. 1994 Mar;111(3):652-4. Erratum in: Br J Pharmacol 1996 Jan;117(1):231.

37.

Hecker M, Pörsti I, Bara AT, Busse R. Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level. Br J Pharmacol. 1994 Jan;111(1):238-44.

36.

Pörsti I, Hecker M, Bassenge E, Busse R. Dual action of angiotensin II on coronary resistance in the isolated perfused rabbit heart. Naunyn Schmiedebergs Arch Pharmacol. 1993 Dec;348(6):650-8.

35.

Hecker M, Bara AT, Busse R. Relaxation of isolated coronary arteries by angiotensin-converting enzyme inhibitors: role of endothelium-derived kinins. J Vasc Res. 1993 Sep-Oct;30(5):257-62.

34.

Hecker M, Mülsch A, Bassenge E, Busse R. Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol. 1993 Sep;265(3 Pt 2):H828-33.

33.

Hecker M, Lückhoff A, Busse R. Modulation of endothelial autacoid release by protein kinase C: feedback inhibition or non-specific attenuation of receptor-dependent cell activation? J Cell Physiol. 1993 Sep;156(3):571-8.

32.

Macarthur H, Hecker M, Busse R, Vane JR. Selective inhibition of agonist-induced but not shear stress-dependent release of endothelial autacoids by thapsigargin. Br J Pharmacol. 1993 Jan;108(1):100-5.

31.

Mülsch A, Hecker M, Mordvintcev PI, Vanin AF, Busse R. Enzymic and nonenzymic release of NO accounts for the vasodilator activity of the metabolites of CAS 936, a novel long-acting sydnonimine derivative. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jan;347(1):92-100.

30.

Zembowicz A, Swierkosz TA, Southan GJ, Hecker M, Vane JR. Potentiation of the vasorelaxant activity of nitric oxide by hydroxyguanidine: implications for the nature of endothelium-derived relaxing factor. Br J Pharmacol. 1992 Dec;107(4):1001-7.

29.

Kaw S, Hecker M, Vane JR. The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6886-90.

28.

D'Orleans-Juste P, Mitchell JA, Wood EG, Hecker M, Vane JR. Comparison of the release of vasoactive factors from venous and arterial bovine cultured endothelial cells. Can J Physiol Pharmacol. 1992 May;70(5):687-94.

27.

Hecker M, Siegle I, Macarthur H, Sessa WC, Vane JR. Role of intracellular thiols in release of EDRF from cultured endothelial cells. Am J Physiol. 1992 Mar;262(3 Pt 2):H888-96.

26.

Hecker M, Kaw S, Walsh DT. Determination of endothelin-converting enzyme activity by high-performance liquid chromatography-on-line radioactive flow monitoring. J Chromatogr. 1992 Feb 14;574(2):344-8.

25.

Zembowicz A, Hecker M, Macarthur H, Sessa WC, Vane JR. Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11172-6.

24.

Hecker M, Walsh DT, Vane JR. On the substrate specificity of nitric oxide synthase. FEBS Lett. 1991 Dec 9;294(3):221-4.

23.

Thiemermann C, Mustafa M, Mester PA, Mitchell JA, Hecker M, Vane JR. Inhibition of the release of endothelium-derived relaxing factor in vitro and in vivo by dipeptides containing NG-nitro-L-arginine. Br J Pharmacol. 1991 Sep;104(1):31-8.

22.

MacIntyre I, Zaidi M, Alam AS, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR. Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2936-40.

21.

Thiemermann C, al-Damluji S, Hecker M, Vane JR. FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system. Biochem Biophys Res Commun. 1991 Feb 28;175(1):318-24.

20.

Sessa WC, Kaw S, Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991 Jan 31;174(2):613-8.

19.

Hecker M, Sessa WC, Harris HJ, Anggård EE, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8612-6.

18.

Sessa WC, Hecker M, Mitchell JA, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8607-11.

17.

Swierkosz TA, Mitchell JA, Sessa WC, Hecker M, Vane JR. L-glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta. Biochem Biophys Res Commun. 1990 Oct 15;172(1):143-8.

16.

Hecker M, Mitchell JA, Swierkosz TA, Sessa WC, Vane JR. Inhibition by L-glutamine of the release of endothelium-derived relaxing factor from cultured endothelial cells. Br J Pharmacol. 1990 Oct;101(2):237-9.

15.

Mitchell JA, Hecker M, Anggård EE, Vane JR. Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF. Eur J Pharmacol. 1990 Jul 17;182(3):573-6.

14.

Rosenbach T, Czernielewski J, Hecker M, Czarnetzki B. Comparison of eicosanoid generation by highly purified human Langerhans cells and keratinocytes. J Invest Dermatol. 1990 Jul;95(1):104-7.

13.

Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR. Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochem Biophys Res Commun. 1990 Mar 30;167(3):1037-43.

12.

Mitchell JA, Hecker M, Vane JR. The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor. Eur J Pharmacol. 1990 Feb 6;176(2):253-4.

11.

Hecker M, Brüne B, Decker K, Ullrich V. The sulfhydryl reagent thimerosal elicits human platelet aggregation by mobilization of intracellular calcium and secondary prostaglandin endoperoxide formation. Biochem Biophys Res Commun. 1989 Mar 31;159(3):961-8.

10.

Thomas G, Hecker M, Ramwell PW. Vascular activity of polycations and basic amino acids: L-arginine does not specifically elicit endothelium-dependent relaxation. Biochem Biophys Res Commun. 1989 Jan 16;158(1):177-80.

9.

Hecker M, Ullrich V. On the mechanism of prostacyclin and thromboxane A2 biosynthesis. J Biol Chem. 1989 Jan 5;264(1):141-50.

8.

Hecker M, Ullrich V. Studies on the interaction of minoxidil with prostacyclin synthase in vitro. Biochem Pharmacol. 1988 Sep 1;37(17):3363-5.

7.

Hecker M, Ullrich V. 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro. Eicosanoids. 1988;1(1):19-25.

6.

Hecker M, Baader WJ, Weber P, Ullrich V. Thromboxane synthase catalyses hydroxylations of prostaglandin H2 analogs in the presence of iodosylbenzene. Eur J Biochem. 1987 Dec 15;169(3):563-9.

5.

Hofmann U, Meese CO, Hecker M, Ullrich V (1987): Synthesis of novel prostaglandin F2 isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide. Tetrahedron Lett. 28, 5655-5658.

4.

Hecker M, Ullrich V, Fischer C, Meese CO. Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase. Eur J Biochem. 1987 Nov 16;169(1):113-23.

3.

Hecker M, Haurand M, Ullrich V, Diczfalusy U, Hammarström S. Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay. Arch Biochem Biophys. 1987 Apr;254(1):124-35.

2.

Hecker M, Hatzelmann A, Ullrich V. Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites. Biochem Pharmacol. 1987 Mar 15;36(6):851-5.

1.

Hecker M, Haurand M, Ullrich V, Terao S. Spectral studies on structure-activity relationships of thromboxane synthase inhibitors. Eur J Biochem. 1986 May 15;157(1):217-23.

Originalarbeiten in Journal Supplements oder Büchern

23.

Hecker M, Preiss C, Stockhausen H, Klemm P, Schini-Kerth VB, Fisslthaler B, Busse R (1996): Different mechanisms are involved in the inhibition of nitric oxide synthase expression by antioxidants in cytokine-stimulated macrophages. In: Biology of Nitric Oxide 5 (S. Moncada, J.S. Stamler, S.S. Gross, E.A. Higgs, eds.), p. 92, Portland Press, Colchester.

22.

Popp R, Bauersachs J, Sauer E, Hecker M, Fleming I, Busse R (1996): The cytochrome P450 monooxygenase pathway and nitric oxide-independent relaxations. In: Endothelium-Derived Hyperpolarizing Factor, Endothelial Cell Research Series, Volume 1 (ed. by P.M. Vanhoutte), pp. 65-72, Harwood Academic Publishers, Amsterdam.

21.

Bauersachs J, Lischke V, Busse R, Hecker M (1996): Endothelium-dependent hyperpolarization in the coronary microcirculation. In: Endothelium-Derived Hyperpolarizing Factor, Endothelial Cell Research Series, Volume 1 (ed. by P.M. Vanhoutte), pp. 211-216, Harwood Academic Publishers, Amsterdam.

20.

Hecker M, Bara AT, Nestler F, Pörsti I, Busse R (1996): On the mechanism of the coronary dilator response to ACE inhibitors. In: Funktionsanalyse Biologischer Systeme 25, Tissue Reactions in Response to Hypoxia and Ischemia (J. Grote, C. Stick, eds.), pp. 91-101, Gustav Fischer Verlag, Stuttgart.

19.

Hecker M, Bara AT, Busse R. Potentiation of the biological efficacy of bradykinin by ACE inhibitors: a shift in the affinity of the B2 receptor? Immunopharmacology. 1996 Jun;33(1-3):93-4.

18.

Southan GJ, Gross SS, Hecker M, Mallet AI, Parkes HG, Änggård EE, Vane JR (1994): Adducts of hydroxyguanidine compounds and nitric oxide: A novel class of NO donors. In: Biology of Nitric oxide 4: Enzymology, Biochemistry and Immunology (S. Moncada, M. Feelisch, R. Busse, E.A. Higgs, eds.), pp. 255-259, Portland Press, Colchester.

17.

Fleming I, Hecker M, Busse R (1994): Intracellular pH regulates nitric oxide synthase activity in endothelial cells. In: Biology of Nitric Oxide 3: Physiological and Clinical Aspects (S. Moncada, M. Feelisch, R. Busse, E.A. Higgs, eds.), pp. 18-22, Portland Press, Colchester.

16.

Hecker M, Pörsti I, Busse R. Mechanisms involved in the angiotensin II-independent hypotensive action of ACE inhibitors. Braz J Med Biol Res. 1994 Aug;27(8):1917-21.

15.

Hecker M, Fleming I, Pörsti I, Busse R (1993): ACE inhibitors, kinins and endothelial autacoid formation. Pharm. Pharmacol. Lett. 3 (Suppl.), 64-67.

14.

Hecker M, Pörsti I, Bara AT, Busse R (1993): ACE inhibitor are bradykinin-potentiating factors in the coronary circulation. In: ACE Inhibitors, Endothelial Function and Atherosclerosis (T. Unger, B. Schölkens, eds.), pp. 43-59, Media Medica, Chichester.

13.

Hecker M, Bara AT, Busse R. Angiotensin-converting enzyme inhibitors unmask endogenous kinin production by bovine coronary artery endothelium. Eur Heart J. 1993 Nov;14 Suppl I:161-3.

12.

Busse R, Fleming I, Hecker M. Endothelium-derived bradykinin: implications for angiotensin-converting enzyme-inhibitor therapy. J Cardiovasc Pharmacol. 1993;22 Suppl 5:S31-6.

11.

Zembowicz A, Swierkosz TA, Southan GJ, Hecker M, Gryglewski RJ, Vane JR. Mechanisms of the endothelium-dependent relaxation induced by NG-hydroxy-L-arginine. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S57-9.

10.

Kaw S, Hecker M, Southan GJ, Warner TD, Vane JR. Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S22-4.

9.

Hecker M, Walsh DT, Vane JR. Characterization of a microsomal calcium-dependent nitric oxide synthase in activated J774.2 monocyte/macrophages. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S139-41.

8.

Hecker M, Macarthur H, Sessa WC, Southan GJ, Swierkosz TA, Walsh DT, Zembowicz A, Vane JR (1992): NG-Hydroxy-l-arginine: A nitric oxide synthase-independent vasodilator and potential intercellular nitric oxide carrier. In: Biology of Nitric Oxide Part 2. Biochemistry, Enzymology and Immunology (S. Moncada, M.A. Marletta, J.B. Hibbs, E.A. Higgs, eds.), pp. 128-130, Portland Press, Colchester.

7.

Hecker M, Dambacher T, Busse R. Role of endothelium-derived bradykinin in the control of vascular tone. J Cardiovasc Pharmacol. 1992;20 Suppl 9:S55-61.

6.

Hecker M, Benzing T, Busse R. Stimulation of endothelial autacoid formation by inhibitors of angiotensin-converting enzyme. Agents Actions Suppl. 1992;38 ( Pt 3):163-70.

5.

Sessa WC, Kaw S, Zembowicz A, Anggård E, Hecker M, Vane JR. Human polymorphonuclear leukocytes generate and degrade endothelin-1 by two distinct neutral proteases. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S34-8.

4.

Hecker M, Sessa WC, Mitchell JA, Änggård EE, Vane JR (1990): The biosynthesis of EDRF by endothelial cells as a means of removing excess nitrogen. J. Cardiovasc. Pharmacol. 17 (Suppl. 3), S19-S24.

3.

Ullrich V, Haurand M, Hecker M (1989): The significance of the heme-thiolate structure of prostacyclin and thromboxane synthase. In: Cytochrome P-450: Biochemistry and Biophysics (ed. by I. Schuster), pp. 41-48, Taylor, Francis, London.

2.

Ullrich V, Hecker M (1989): A cage radical mechanism for prostacyclin and thromboxane synthase. In: Medical, Biochemical and Chemical Aspects of Free Radicals (O. Hayaishi, E. Niki, M. Kondo, T. Yoshikawa, eds.), pp. 1073-1080, Elsevier Science Publishers, Amsterdam.

1.

Ullrich V, Hecker M (1987): Oxene transfer as a common principle of monooxygenase and thromboxane synthase. In: Proceedings of Yamada Conference XVII on Cytochrome P-450: New Trends (R. Sato, T. Omura, Y. Imai, Y. Fujii-Kuriyama, eds.), Yamda Science Foundation, Japan.

Übersichtsarbeiten in Journalen mit Peer Review, Journal Supplements oder Büchern; Buchbeiträge und Bücher

22.

Hecker M. 4.2 Kreislauf. In: Physiologie hoch2 (Gründer S, Schlüter KD, eds.) Urban & Fischer Verlag/Elsevier GmbH 2019, pp. 192-225. ISBN  978-3-437-43461-7

21.

Hecker M, Wagner AH. Role of protein carbonylation in diabetes. J Inherit Metab Dis. 2018 Jan;41(1):29-38. doi: 10.1007/s10545-017-0104-9. Epub 2017 Nov 6

20.

Hecker M, Wagner AH. Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

19.

Firasat S, Hecker M, Binder L, Asif AR. Advances in endothelial shear stress proteomics. Expert Rev Proteomics. 2014 Oct;11(5):611-9. doi: 10.1586/14789450.2014.933673. Epub 2014 Jul 12.

18.

Pfisterer L, König G, Hecker M, Korff T. Pathogenesis of varicose veins - lessons from biomechanics. Vasa. 2014 March;43(2):88-99.doi: 10.1024/0301-1526/a000335.

17.

Cattaruzza M, Wagner AH, Hecker M. Mechanosensitive pro-inflammatory gene expression in vascular cells. In: Mechanical Stretch and Cytokines, Mechanosensitivity in Cells and Tissues, Vol. 5. A. Kamkin, I. Kiseleva (Eds.) Springer Science+Business Media B. V. 2012, pp. 59-86.

16.

Stojanovic T, Wagner A, Schöndube FA, Hecker M. Pre-Transplant Therapy in Experimental Heart Transplantation. In: Cardiac Transplantation. Susan D. Moffatt-Bruce (Ed.) InTech. 2012, pp. 143-154. ISBN 978-953-51-0000-3

15.

Rewerk S, Meyer R, Hecker M, Korff T. Durch die Augen von Laplace: Die Rolle der Wandspannung bei Varikosis. Phlebologie 2012;41(2):61-7.

14.

Hecker M, Wagner S, Henning SW, Wagner AH. Decoy oligodeoxynucleotides to treat inflammatory diseases. (book chapter) In: Therapeutic Oligonucleotides 2008; (ed. Kurreck J) RSC Publishing, Cambridge, U.K., pp. 163-188.

13.

Hecker M (2000): Endothelium-derived hyperpolarizing factor - fact or fiction? News Physiol. Sci. 15, 1-5.

12.

Hecker M, Cattaruzza M, Wagner AH. Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Gen Pharmacol. 1999 Jan;32(1):9-16. Review.

11.

Lischke V, Kessler P, Hecker M. Anästhetika und Stickstoffmonoxid (NO): Interaktionen und ihre Bedeutung für die Anästhesie [Anesthetics and nitric oxide.Interactions and their importance for anesthesia] Anaesthesist. 1997 Aug;46(8):659-76. Review.

10.

Hecker M, Fleming I, Ayajiki K, Busse R (1996): Mechanisms of shear stress-dependent endothelial nitric oxide release: Cardiovascular implications. In: Biochemical, Pharmacological and Clinical Aspects of Nitric Oxide (B.A. Weissman, H. Allon, S. Shapira, eds.), pp. 49-56, Plenum Press, London.

9.

Hecker M, Billiar TR (1996): Detection of L-arginine, related metabolites and guanidino compounds. In: Methods in Nitric Oxide Research (M. Feelisch, J. Stamler, eds.), pp. 259-270, John Wiley, Sons, Chichester.

8.

Hecker M, Fleming I, Busse R. Kinin-mediated activation of endothelial no formation: possible role during myocardial ischemia. Agents Actions Suppl. 1995;45:119-27. Review.

7.

Busse R, Hecker M, Fleming I. Control of nitric oxide and prostacyclin synthesis in endothelial cells. Arzneimittelforschung. 1994 Mar;44(3A):392-6. Review.

6.

Busse R, Hecker M. Endotheliale Mechanismen bei vasomotorischen Effekten von ACE-Inhibitoren [Endothelial mechanisms in vasomotor effects of ACE inhibitors] Z Kardiol. 1994;83 Suppl 4:1-6. Review.

5.

Busse R, Fleming I, Hecker M. Signal transduction in endothelium-dependent vasodilatation. Eur Heart J. 1993 Nov;14 Suppl I:2-9. Review.

4.

Busse R, Mülsch A, Fleming I, Hecker M (1993): Mechanisms of nitric oxide release from the vascular endothelium. Circulation 87 (Suppl. V), V18-V25.

3.

Hecker M, Busse R (1992): Interactions between endothelium-derived prostacyclin and nitric oxide: Mechanisms and cellular effects. In: Novel Perspectives in Prostacyclin Research (G.R. Rubanyi, JR Vane, eds.), Excerpta Medica, Int. Congr. Ser. vol. 1004, pp. 93-112, Elsevier Science Publishers, Amsterdam.

2.

Ullrich V, Hecker M. A concept for the mechanism of prostacyclin and thromboxane A2 biosynthesis. Adv Prostaglandin Thromboxane Leukot Res. 1990;20:95-101. Review.

1.

Ullrich V, Hecker M, Nüsing R, Rosenbach T (1988): Thromboxane A2 and prostacyclin in tumorigenesis. In: Eicosanoids, Lipid Peroxidation and Cancer (Nigam et al, eds.), pp. 3-10, Springer-Verlag, Heidelberg.

Andere Artikel, z. B. Editorials

3.

Bie P, Brandes R, Deuchars S, Eisner D, Fandrey J, Hecker M, Louch W, Taira T, Yilmaz B. Bringing European physiologists together. Acta Physiol (Oxf). 2018 Apr;222(4):e13043. doi: 10.1111/apha.13043. Epub 2018 Feb 15.

2.

Graier WF, Hecker M. Endothelial H2O2: a bad guy turning good?  Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1691-3. No abstract available.

1.

Cattaruzza M, Hecker M. Protein carbonylation and decarboylation: a new twist to the complex response of vascular cells to oxidative stress. Circ Res. 2008 Feb 15;102(3):273-4.


Neue Publikationen

*

Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020 Mar 1;388(1):111782. doi: 10.1016/j.yexcr.2019.111782. Epub 2019 Dec 16.

*

Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory. Elife. 2020 Feb 7;9. pii: e49974. doi: 10.7554/eLife.49974.

*

AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice. J Heart Lung Transplant. 2020 Jan 30. pii: S1053-2498(20)31356-5. doi: 10.1016/j.healun.2020.01.1338. [Epub ahead of print]

*

Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes. BMC Anesthesiol. 2020 Jan 8;20(1):10. doi: 10.1186/s12871-019-0926-0.

*

Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples. Appl Microbiol Biotechnol. 2020 Jan;104(1):131-144. doi: 10.1007/s00253-019-10242-1. Epub 2019 Nov 28.

*

Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

*

Simulation Strategies for Calcium Microdomains and Calcium Noise. Adv Exp Med Biol. 2020;1131:771-797. doi: 10.1007/978-3-030-12457-1_31.

*

Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PLoS One. 2019 Dec 17;14(12):e0226675. doi: 10.1371/journal.pone.0226675. eCollection 2019.

*

Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print

*

Risk and protective factors for post-thrombotic syndrome after deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2019 Dec 13. pii: S2213-333X(19)30537-2. doi: 10.1016/j.jvsv.2019.10.012. [Epub ahead of print]

*

AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts. Mol Ther Methods Clin Dev. 2019 Dec 13;15:246-256. doi: 10.1016/j.omtm.2019.09.009. eCollection 2019 Dec 13. Epub 2019 Oct 2.

*

Amyloid, APP, and Electrical Activity of the Brain. Neuroscientist. 2019 Nov 29:1073858419882619. doi: 10.1177/1073858419882619. [Epub ahead of print]

*

The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]

*

Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

*

Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Sci Rep. 2019 Dec 3;9(1):18224. doi: 10.1038/s41598-019-54807-6.

*

Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. doi: 10.1002/glia.23683. Epub 2019 Jul 17.

*

Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4056
Telefax:+49 6221 54-6364
E-Mail:susanne.bechtel@
physiologie.uni-heidelberg.de