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Institute of Pharmacology

Selected Publications

Research Articles

  1. Dutta Banik D, Martin LE, Freichel M, Torregrossa AM, Medler KF. TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells. Proc Natl Acad Sci USA pii: 201718802. doi: 10.1073/pnas.1718802115
  2. Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med 24, 62-72, 2018
  3. Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M. Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J 36, 2770-89, 2017
  4. Hartmann AK, Arande Lopez P, Zajac M, Freichel M, Schild R, Radsak MP, Stassen M. 9-phenanthrol enhances the generation of an CD8± T cell response following transcutaneous immunization with imiquimod in mice. J Dermatol Sci 87, 260-7, 2017
  5. Beck A, Götz V, Qiao S, Weissgerber P, Flockerzi V, Freichel M, Boehm U. Functional characterization of transient receptor potential (TRP) channel C5 in female murine gonadotropes. Endocrinology 158, 887-902, 2017
  6. Morgenstern J, Fleming T, Schumacher D, Eckstein V, Freichel M, Herzig S, Nawroth P. Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian Schwann cells. J Biol Chem 292, 3224-38, 2017
  7. Solís-López A, Kriebs U, Marx A, Mannebach S, Liedtke WB, Caterina MJ, Freichel M, Tsvilovskyy VV. Analysis of TRPV channel activation by stimulation of FCεRI and MRGPRn receptors in mouse peritoneal mast cells. PLoS One 12:e0171366, 2017
  8. Danielczok J, Hertz L, Ruppenthal S, Kaiser E, Petkova-Kirova P, Bogdanova A, Krause E, Lipp P, Freichel M, Kaestner L, Birnbaumer L. Does erythropoietin regulate TRPC channels in red blood cells? Cell Physiol Biochem 41, 1219-228, 2017
  9. Rixecker T, Mathar I, Medert R, Mannebach S, Pfeifer A, Lipp P, Tsvilovskyy V, Freichel M. TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells. Sci Rep 6, 32981, 2016.doi: 10.1038/srep32981
  10. Kurland DB, Gerzanich V, Karimy JK, Woo SK, Vennekens R, Freichel M, Nilius B, Bryan J, Simard JM. The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia. J Neuroinflammation 13, 130, 2016. doi: 10.1186/s12974-016-0599-2
  11. Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, Vennekens R, Balschun D. TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch 468, 593-607, 2016. doi: 10.1007/s00424-015-1764-7
  12. Klepac K, Kilic A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun 7, 10895, 2016. doi: 10.1038/ncomms10895
  13. Zhang W, Freichel M, van der Hoeven F, Nawroth PP, Katus H, Kälble F, Zitron E, Schwenger V. Novel endothelial cell-specific AQP1 knockout mice confirm the crucial role of endothelial AQP1 in ultrafiltration during peritoneal dialysis. PLos One 11:e0135513, 2016. doi: 10.1371/journal.pone.0145513
  14. Jha A, Singh AK, Weissgerber P, Freichel M, Flockerzi V, Flavell RA, Jha MK. Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis. Sci Signal 8, ra103. doi: 10.1126/scisignal.aac7538
  15. Uhl S, Freichel M, Mathar I. Contractility measurements on isolated papillary muscles for the investigation of cardiac inotropy in mice. J Vis Exp 103. doi: 10.3791/53076
  16. Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M*, Lipp P*. A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. Eur Heart J Jun 11. pii. ehv.250, 2015
    *shared senior authorship
  17. Kecskés M, Jacobs G, Kerselaers S, Syam N, Menigoz A, Vangheluve P, Freichel M, Flockerzi V, Voets T, Vennekens R. The (Ca2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. Basic Res Cardiol 110, 501, 2015
  18. Uhl S, Mathar I, Vennekens R, Freichel M. Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice. J Mol Cell Cadiol 74: 307-17, 2014
  19. Kang D, Wang J, Hogan JO, Vennekens R, Freichel M, White C, Kim D. Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body. J Physiol 592: 1975-92, 2014
  20. Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londoño JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R. Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice. Circ Res 114: 283-94, 2014
  21. Tian J, Thakur DP, Lu Y, Zhu Y, Freichel M, Flockerzi V, Zhu MX. Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch 466: 1301-16, 2014
  22. Boudes M, Uvin P, Pinto S, Freichel M, Birnbaumer L, Voets T, De Ridder D, Vennekens R. Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PLoS One 8: e69550, 2013
  23. Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, Hofmann F, Wegener JW. The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. Cardiovasc Res 100: 280-7, 2013
  24. Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW. Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure. Sci Signal 6: ra50, 2013
  25. Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Chang HF, Guzman R, Olausson J, Freichel M, Schmitz F, Pasche M, Becherer U, Bruns D, Rettig J. Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion. Nat Commun 4: 1439, 2013
  26. Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol 83: 429-38, 2013
  27. Suresh Babu S, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanisms of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal 5: ra91, 2012
  28. Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 18: 1805-11, 2012
  29. Woudenberg-Vrenken TE, Lameris AL, Weißgerber P, Olausson J, Flockerzi V, Bindels RJ, Freichel M, Hoenderop JG. Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am J Physiol Gastrointest Liver Physiol 303: G879-85, 2012
  30. Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol 2: 120068, 2012
  31. Stroh O, Freichel M, Kretz O, Birnbaumer L, Hartmann J, Egger V. NDMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells. J Neurocsi 32: 5737-46, 2012
  32. Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. J Biol Chem 287: 17930-41, 2012
  33. Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A. Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun 3: 649.doi: 10.1038/ncomms1660, 2012
  34. Samapati R, Yang Y, Yin J, Stoerger C, Arenz C, Dietrich A, Gudermann T, Adam D, Wu S, Freichel M, Flockerzi V, Uhlig S, Kuebler WM. Lund endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. Am J Respir Crit Care Med 185: 160-70, 2012
  35. Sudivakkam PC, Freichel M, Singh V, Yuan JP, Vogel SM, Flockerzi V, Malik AB, Tiruppathi C. The Ca2+ sensor STIM1 is necessary and sufficient for the store-operated Ca2+ entry function of TRPCs in endothelial cells. Mol Pharmacol 81: 510-26, 2012
  36. Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Heteromeric TRPC1/TRPC4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol 81: 384-92, 2012
  37. van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG, Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP. The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice. J Cell Physiol 227: 1951-9, 2012
  38. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature 479: 67-73, 2011
  39. Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev VO, Yang RB, Völker K, Gassner B, Oberwinkler H, Feil R, Freichel M, Groschner K, Skryabin BV, Frantz S, Birnbaumer L, Pongs O, Kuhn M. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A 108: 18500-5, 2011
  40. Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. Male fertility depends on Ca2+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4 (171): ra27, 2011
  41. Custodis F, Gertz K, Balkaya M, Prinz V, Mathar I, Stamm C, Kronenberg G, Kazakov A, Freichel M, Böhm M, Endres M, Laufs U. Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice. Stroke 42: 1742-9, 2011
  42. Meissner M, Weissgerber P, Londoño JE, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V. Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. J Biol Chem 286: 15857-82, 2011
  43. Mathar I, Vennekens R, Meissner M, Kees F, VAn der Mieren G, Camacho-Londoño, JE, Uhl S, Voets T, Hummel B, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M. Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest 120: 3267-79, 2010
  44. Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño, JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, Kihn M. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol 105: 583-95, 2010
  45. Jha MK, Badou A, Meissner M, McRory JE, Freichel M, Flockerzi V, Flavell RA. Defective survival of naïve CD8+ T lymphocytes in the absence of β3 regulatory subunit of CaV channels. Nat Immunol 10: 1275-82, 2009
  46. Link  S, Meissner M, Held B, Beck A, Weißgerber P, Freichel M, Flockerzi V. Diversity and developmental expression of CaVb2 proteins in the murine heart and their influence on calcium current in murine heart. J Biol Chem 284: 30129-37, 2009
  47. Kuhn S, Knirsch M, Rüttinger L, Kasperek S, Winter H, Freichel M, Flockerzi V, Knipper M, Engel J. Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits β3 or β4. Channels (Austin) 3: 366-76, 2009
  48. Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V. Deletion of TRPC4 and TRPC6 impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology 137: 1415-24, 2009
  49. Gerzanich V, Woo K, Vennekens R, Tsymbalyuk SO, Ivanova S, Ivanov A, Geng Z, Chen Z, Flockerzi V, Nilius B, Freichel M, Simard JM. De novo expression of TRPM4 initiates secondary hemorrhage in spinal cord injury. Nat Med 15: 185-91, 2009
  50. Bair AM, Thippegowda PB, Freichel M, Cheng N, Ye RD, Vogel SM, Yu Y, Flockerzi V, Malik AB, Tiruppathi C. Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-κB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cδ. J Biol Chem 284: 563-74, 2009
  51. Shimizu T, Owsianik G, Freichel M, Flockerzi V, Nilius B, Vennekens R. TRPM4 regulates migration of mast cells in mice. Cell Calcium 45: 226-32, 2009
  52. Hartmann J, Dragicevic E, Adelsberger H, Henning H, Sumsser M, Abramowitz J, Blum R, Dietrich M, Freichel M, Flockerzi V, Birnbaumer L, Konnerth A. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59: 392-8, 2008
  53. Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy VV, Ito S, Flockerzi V, Zhu MX, Zholos AV. Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 238: 10026-36, 2008
  54. Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 8: 312-20, 2007
  55. Andronache Z, Ursu D, Lehnert S, Freichel M, Flockerzi V, Melzer W. The auxiliary subunit γ1 of the skeletal muscle L-type calcium channel is an endogenous calcium antagonist. Proc Natl Acad Sci U S A 104: 17885-90, 2007
  56. Held B, Tsvilovskyy V, Meissner M, Kästner L, Ludwig A, Mossmang S, Lipp P, Freichel M, Flockerzi V. Ca2+ channel currents and contraction in CaVβ3-deficient ileum smooth muscle from mouse. Cell Calcium 42: 477-87, 2007
  57. Gross SA, Wissenbach U, Philipp SE, Freichel M, Cavalié A, Flockerzi V. Murine ORAI2 splice variants form functional CRAC channels. J Biol Chem 282: 19375-84, 2007
  58. Singh U, Sun T, Looman C, Heuchel R, Elliot R, Freichel M, Meissner M, Flockerzi V, Fundele R. Expression and function of the gene encoding the voltage-dependent calcium channel beta3-subunit in the mouse placenta. Placenta 28: 412-20, 2007
  59. Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V, Flavell RA. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte funtion. Proc Natl Acad Sci U S A 103: 15529-34, 2006
  60. Weißgerber P, Held B, Bloch W, Kästner L, Chien K, Fleischmann B, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in CaVβ2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res 99: 749-57, 2006
  61. Aneiros E, Philipp S, Lis A, Freichel M, Cavalié A. Modulation of Ca2+ signalling by Na+/Ca2+ exchangers in mast cells. J Immunol 174: 119-30, 2005
  62. Berggren PO, Yang S, Murakami M, Efanov A, Uhles S, Köhler M, Moede T, Fernström A, Appelskog I, Aspinwall C, Zaitsev S, Larsson O, Moitosos de Vargas L, Fecher-Trost C, Weißgerber P, Ludwig A, Leibiger B, Juntti-Bergen L, Barker CJ, Gromada J, Freichel M, Leibiger I, Flockerzi V. Removal of Ca2+ channel β3 subunit enhances Ca2+ oscillations frequency and insulin exocytosis. Cell 119: 273-84, 2004
  63. Ursu D, Schuhmeier RP, Freichel M, Flockerzi V, Melzer D. Altered Ca2+ current, Ca2+ release and force in adult mouse muscle fibers deficient of the DHP-receptor γ1 subunit. J Gen Physiol 124: 605-18, 2004
  64. Munsch T, Freichel M, Flockerzi V, Pape H. Contribution of transient receptor potential channels to serotonin-mediated increase in GABA release from dendrites. Proc Natl Acad Sci U S A 100: 16065-70, 2003
  65. Nilius B, Prenen J, Droogmanns G, Voets T, Vennekens R, Freichel M, Wissenbach U, Flockerzi V. Voltage dependence of the Ca2+ activated cation channel TRPM4. J Biol Chem 278: 30813-20, 2003
  66. Hirnet D*, Olausson J*, Fecher-Trost C, Bödding M, Nastainczyk W, Wissenbach U, Flockerzi V, Freichel M. The TRPV6 gene, cDNA and protein. Cell Calcium 33: 509-18, 2003
  67. Bosel J, John M, Freichel M, Blind E. Signaling of the human calcium-sensing receptor expressed in HEK293-cells is modulated by protein kinases A and C. Exp Clin Endocrinol Diabetes 111: 21-6, 2003
  68. Murakami M, Fleischmann B, De Felipe C, Freichel M, Trost C, Ludwig A, Wissenbach U, Schwegler H, Hofmann F, Hescheler J, Flockerzi V, Cavalié A. Pain perception in mice lacking the β3 subunit of voltage-activated calcium channels. J Biol Chem 277: 40342-51, 2002
  69. Tiruppathi C, Freichel M, Vogel SM, Paria BC, Metha D, Flockerzi V, Malik AB. Impairment of store-operated Ca2+ entry in TRPC4-/- mice interferes with thrombin-induced increase in lung microvascular permeability. Circ Res 91: 70-6, 2002
  70. Held B, Freise D, Freichel M, Hoth M, Flockerzi V. Skeletal muscle L-type Ca2+ current modulation in γ1-deficient and wildtype myotubes by the γ1 subunit and cAMP. J Physiol 539: 459-68, 2002
  71. Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weißgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B. Lack of anendothelial store-operated Ca2+ current impairs agonist-dependent Ca2+ entry and vasorelaxation in TRP4 (CCE1)-/- mice. Nat Cell Biol 3: 121-7, 2001
  72. Wei L, Freichel M, Jaspers M, Cuppens H, Cassiman JJ, Droogmans G, Flockerzi V, Nilius B. Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells. BMC Physiology 1: 3, 2001
  73. Quitterer U, Hoffmann M, Freichel M, Lohse MJ. Paradoxical block of parathormone secretion is mediated by increased activity of G protein α subunits. J Biol Chem 276: 6763-9, 2001
  74. Wissenbach U, Bödding M, Freichel M, Flockerzi V. Trp12, a novel Trp related protein from kidney. FEBS Lett 485: 127-34, 2000
  75. Freise D, Held B, Wissenbach U, Pfeifer A, Trost C, Himmerkus N, Schweig U, Freichel M, Biel M, Hofmann F, Hoth M, Flockerzi V. Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties. J Biol Chem 275: 14476-81, 2000
  76. Zimmer S, Trost C, Wissenbach U, Philipp S, Freichel M, Flockerzi V, Cavalié A. Modulation of recombinant transient-receptor-potential-like (TRPL) channels by cytosolic Ca2+. Pflügers Arch 440: 409-17, 2000
  77. Suh SH, Vennekens R, Manolopoulos VG, Freichel M, Schweig U, Prenen J, Flockerzi V, Droogmans G, Nilius B. Characterisation of explanted endothelial cells from mouse aorta: electrophysiology and Ca2+ signaling. Pflügers Arch 438: 612-20, 1999
  78. Philipp S, Hambrecht J, Brqaslavski L, Schroth G, Freichel M, Murakami M, Cavalié A, Flockerzi V. A novel capacitative calcium entry channel expressed in excitable cells. EMBO J 17: 4274-82, 1998
  79. Freichel M, Wissenbach U, Philipp S, Flockerzi V. Alternative splicing and tissue specific expression of the 5' truncated bCCE1 variant bCCE1Δ514. FEBS Lett 422: 354-8, 1998
  80. Philipp S, Cavalié A, Freichel M, Wissenbach U, Zimmer S, Trost C, Marquart A, Manabu M, Flockerzi V. A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J 15: 6166-71, 1996
  81. Freichel M, Zink-Lorenz A, Holloschi A, Hafner M, Flockerzi V, Raue F. Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion. Endocrinology 137: 3842-8, 1996
  82. Biel M, Altenhofen W, Hullin R, Ludwig J, Freichel M, Flockerzi V, Dascal N, Kaupp UB, Hofmann F. Primary structure and functional expression of a cyclic nucleotide gated channel from rabbit aorta. FEBS Lett 329: 134-8, 1993
  83. Hullin R, Singer-Lahat D, Freichel M, Biel M, Dascal N, Hofmann F, Flockerzi V. Calcium channel β subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J 11: 885-90, 1992

Reviews, book chapters and online courses:

  1. Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP. Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention. Int J Mol Sci 18, 2017. pii: E984. doi: 10.3390/ijms18050984
  2. Freichel M, Berlin M, Schürger A, Mathar I, Bacmeister L, Medert R, Frede W, Marx A, Segin S, Londoño JEC. TRP channels in the heart. In: Emir TLR, ed. Neurobiology of TRP channels. 2nd ed, Boca Raton (FL): CRC Press/Taylor & Francis, Chapter 9, 2017
  3. Mathar I, Jacobs G, Kecskés M, Menigoz A, Phillipaert K, Vennekens R. Mammalian transient receptor potential (TRP) cation channels. Handb Exp Pharmacol 222, 462-481, 2014
  4. Freichel M, Tsvilovskyy V, Camacho Londoño JE. TRPC4- and TRPC4-containing channels. Handb Exp Pharmacol 222: 85-128, 2014
  5. Freichel M. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility. In: Simpson, A. (ed.): Calcium signaling I: Regulation, mechanisms, effectors, role in disease and recent advances. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL0293598-Freichel), 2014
  6. Freichel M, Almering J, Tsvilovskyy V. The role of TRP proteins in mast cells. Front Immunol 3: 150, 2012
  7. Freichel M, Kriebs U, Vogt D, Mannebach S, Weißgerber P. Strategies and protocols to generate mouse models with targeted mutations to analyze TRP channel functions. In: Zhu MX (ed.). TRP channels. CRC Press, Boca Raton (FL), chapter 8, 2011
  8. Freichel M, Flockerzi V. Biological functions of TRPs unravelled by spotaneous mutations and transgenic animals. Biochem Soc Trans 35: 120-3, 2007
  9. Freichel M, Vennekens R, Olausson J, Stolz S, Philipp S, Weißgerber P. Flockerzi V. Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol 567: 59-66, 2005
  10. Flockerzi V, Jung C, Aberle T, Meissner M, Freichel M, Philipp SE, Nastainczyk W, Maurer P, Zimmermann R. Specific detection and semi-quantative analysis of TRPC4 protein expression by antibodies. Pflugers Arch 451: 81-6, 2005
  11. Freichel M, Vennekens R, Olausson J, Hoffmann M, Müller C, Stolz S, Scheunemann J, Weißgerber P, Flockerzi V. Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun 322: 1352-8, 2004
  12. Freichel M, Philipp P, Cavalié A, Flockerzi V. TRPC4 and TRPC4 deficient mice. Novartis Found Symp 258: 189-99; discussion 199-203, 263-6, 2004
  13. Freichel M, Schweig U, Stauffenberger S, Freise D, Schorb W, Flockerzi V. Store operated cation channels (SOCs) in the heart and cells of the cardiovascular system. Cell Physiol Biochem 9: 270-83, 1999
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