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Institute of Physiology and Pathophysiology



For older publications please refer to the menu in the right-hand column.


Marked titles are linked to their respective abstract on a freely accessible external website.



Xiyuan Z, Fink RHA, Mosqueira M. NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.


Scheid LM, Weber C, Bopp N, Mosqueira M, Fink RHA. Extraction Protocols for Individual Zebrafish's Ventricle Myosin and Skeletal Muscle Actin for In vitro Motility Assays. Front Physiol. 2017 May 31;8:367. doi: 10.3389/fphys.2017.00367. eCollection 2017.



Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D. Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066. Epub 2016 Mar 24.


Förderer M, Georgiev T, Mosqueira M, Fink RH, Vogel M. Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution. Biomed Opt Express. 2016 Jan 15;7(2):525-41. doi: 10.1364/BOE.7.000525. eCollection 2016 Feb 1.


Schilling R, Fink RH, Fischer WB. Interaction of ions with the luminal sides of wild-type and mutated skeletal muscle ryanodine receptors. J Mol Model. 2016 Jan;22(1):37. doi: 10.1007/s00894-015-2906-8. Epub 2016 Jan 19.


Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F. Oxidative Stress in Disease and Aging: Mechanisms and Therapies. Oxid Med Cell Longev. 2016;2016:8786564. doi: 10.1155/2016/8786564. Epub 2015 Dec 10.



Georgiev T, Zapiec B, Förderer M, Fink RH, Vogel M. Colocalization properties of elementary Ca2+ release signals with structures specific to the contractile filaments and the tubular system of intact mouse skeletal muscle fibers. J Struct Biol. 2015 Dec;192(3):366-375. doi: 10.1016/j.jsb.2015.09.018. Epub 2015 Oct 21.


Zapiec B, Mombaerts P. Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5873-82. doi: 10.1073/pnas.1512135112. Epub 2015 Oct 8.


Georgiev T, Svirin M, Jaimovich E, Fink RH. Localized nuclear and perinuclear Ca(2+) signals in intact mouse skeletal muscle fibers. Front Physiol. 2015 Sep 29;6:263. doi: 10.3389/fphys.2015.00263. eCollection 2015.


Vogel M, Wingert A, Fink RH, Hagl C, Ganikhanov F, Pfeffer CP. Enabling the detection of UV signal in multimodal nonlinear microscopy with catalogue lens components. J Microsc. 2015 Oct;260(1):62-72. doi: 10.1111/jmi.12267. Epub 2015 May 27.


Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P. S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.


Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E. The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E294-305. doi: 10.1152/ajpendo.00189.2014. Epub 2014 Dec 9.


Wieder N, Fink R, von Wegner F. Exact stochastic simulation of a calcium microdomain reveals the impact of Ca²⁺ fluctuations on IP₃R gating. Biophys J. 2015 Feb 3;108(3):557-67. doi: 10.1016/j.bpj.2014.11.3458.



von Wegner F, Wieder N, Fink RH. Microdomain calcium fluctuations as a colored noise process. Front Genet. 2014 Nov 3;5:376. doi: 10.3389/fgene.2014.00376. eCollection 2014.


Wang YT, Schilling R, Fink RH, Fischer WB. Ion-dynamics in hepatitis C virus p7 helical transmembrane domains - a molecular dynamics simulation study. Biophys Chem. 2014 Aug;192C:33-40. doi: 10.1016/j.bpc.2014.06.001. Epub 2014 Jun 16.


Buttgereit A, Weber C, Friedrich O. A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscul Disord. 2014 Jul;24(7):596-603. doi: 10.1016/j.nmd.2014.04.011. Epub 2014 May 4.


Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M. IL-1α reversibly inhibits skeletal muscle ryanodine receptor. A novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol. 2014 Jun;50(6):1096-106. doi: 10.1165/rcmb.2013-0059OC.


Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1. Nat Commun. 2014 May 2;5:3793. doi: 10.1038/ncomms4793.


Schilling R, Fink RH, Fischer WB. MD simulations of the central pore of ryanodine receptors and sequence comparison with 2B protein from coxsackie virus. Biochim Biophys Acta. 2014 Apr;1838(4):1122-31. doi: 10.1016/j.bbamem.2013.12.008. Epub 2013 Dec 21.

Recent Publications


Respiration-Entrained Brain Rhythms Are Global but Often Overlooked. Trends Neurosci. 2018 Feb 8. pii: S0166-2236(18)30031-6. doi: 10.1016/j.tins.2018.01.007. [Epub ahead of print] Review.


Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.


Bringing European physiologists together. Acta Physiol (Oxf). 2018 Jan 29. doi: 10.1111/apha.13043. [Epub ahead of print]


Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. 2018 Jan 19. doi: 10.1002/glia.23292. [Epub ahead of print]


Role of protein carbonylation in diabetes. J Inherit Metab Dis. 2018 Jan;41(1):29-38. doi: 10.1007/s10545-017-0104-9. Epub 2017 Nov 6.


Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes. Anal Bioanal Chem. 2018 Jan;410(2):521-528. doi: 10.1007/s00216-017-0748-1. Epub 2017 Nov 16.


Magnolol inhibits venous remodeling in mice. Sci Rep. 2017 Dec 19;7(1):17820. doi: 10.1038/s41598-017-17910-0.


Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2017 Dec 5. pii: fj.201700384RR. doi: 10.1096/fj.201700384RR. [Epub ahead of print]


AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.


Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.


Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.

Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg


Phone:+49 6221 54-4035
Fax:+49 6221 54-4038