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Institut für Physiologie und Pathophysiologie



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Marked titles are linked to their respective abstract on a freely accessible external website.



Heinz LP, Kopec W, de Groot BL, Fink RHA. In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways. Sci Rep. 2018 May 2;8(1):6886. doi: 10.1038/s41598-018-25061-z.



Xiyuan Z, Fink RHA, Mosqueira M. NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.


Scheid LM, Weber C, Bopp N, Mosqueira M, Fink RHA. Extraction Protocols for Individual Zebrafish's Ventricle Myosin and Skeletal Muscle Actin for In vitro Motility Assays. Front Physiol. 2017 May 31;8:367. doi: 10.3389/fphys.2017.00367. eCollection 2017.



Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D. Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066. Epub 2016 Mar 24.


Förderer M, Georgiev T, Mosqueira M, Fink RH, Vogel M. Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution. Biomed Opt Express. 2016 Jan 15;7(2):525-41. doi: 10.1364/BOE.7.000525. eCollection 2016 Feb 1.


Schilling R, Fink RH, Fischer WB. Interaction of ions with the luminal sides of wild-type and mutated skeletal muscle ryanodine receptors. J Mol Model. 2016 Jan;22(1):37. doi: 10.1007/s00894-015-2906-8. Epub 2016 Jan 19.


Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F. Oxidative Stress in Disease and Aging: Mechanisms and Therapies. Oxid Med Cell Longev. 2016;2016:8786564. doi: 10.1155/2016/8786564. Epub 2015 Dec 10.



Georgiev T, Zapiec B, Förderer M, Fink RH, Vogel M. Colocalization properties of elementary Ca2+ release signals with structures specific to the contractile filaments and the tubular system of intact mouse skeletal muscle fibers. J Struct Biol. 2015 Dec;192(3):366-375. doi: 10.1016/j.jsb.2015.09.018. Epub 2015 Oct 21.


Zapiec B, Mombaerts P. Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5873-82. doi: 10.1073/pnas.1512135112. Epub 2015 Oct 8.


Georgiev T, Svirin M, Jaimovich E, Fink RH. Localized nuclear and perinuclear Ca(2+) signals in intact mouse skeletal muscle fibers. Front Physiol. 2015 Sep 29;6:263. doi: 10.3389/fphys.2015.00263. eCollection 2015.


Vogel M, Wingert A, Fink RH, Hagl C, Ganikhanov F, Pfeffer CP. Enabling the detection of UV signal in multimodal nonlinear microscopy with catalogue lens components. J Microsc. 2015 Oct;260(1):62-72. doi: 10.1111/jmi.12267. Epub 2015 May 27.


Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P. S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.


Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E. The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E294-305. doi: 10.1152/ajpendo.00189.2014. Epub 2014 Dec 9.


Wieder N, Fink R, von Wegner F. Exact stochastic simulation of a calcium microdomain reveals the impact of Ca²⁺ fluctuations on IP₃R gating. Biophys J. 2015 Feb 3;108(3):557-67. doi: 10.1016/j.bpj.2014.11.3458.



von Wegner F, Wieder N, Fink RH. Microdomain calcium fluctuations as a colored noise process. Front Genet. 2014 Nov 3;5:376. doi: 10.3389/fgene.2014.00376. eCollection 2014.


Wang YT, Schilling R, Fink RH, Fischer WB. Ion-dynamics in hepatitis C virus p7 helical transmembrane domains - a molecular dynamics simulation study. Biophys Chem. 2014 Aug;192C:33-40. doi: 10.1016/j.bpc.2014.06.001. Epub 2014 Jun 16.


Buttgereit A, Weber C, Friedrich O. A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscul Disord. 2014 Jul;24(7):596-603. doi: 10.1016/j.nmd.2014.04.011. Epub 2014 May 4.


Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M. IL-1α reversibly inhibits skeletal muscle ryanodine receptor. A novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol. 2014 Jun;50(6):1096-106. doi: 10.1165/rcmb.2013-0059OC.


Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1. Nat Commun. 2014 May 2;5:3793. doi: 10.1038/ncomms4793.


Schilling R, Fink RH, Fischer WB. MD simulations of the central pore of ryanodine receptors and sequence comparison with 2B protein from coxsackie virus. Biochim Biophys Acta. 2014 Apr;1838(4):1122-31. doi: 10.1016/j.bbamem.2013.12.008. Epub 2013 Dec 21.

Neue Publikationen


Selective vulnerability of αOFF retinal ganglion cells during onset of autoimmune optic neuritis. Neuroscience. 2018 Nov 21;393:258-272. doi: 10.1016/j.neuroscience.2018.07.040. Epub 2018 Aug 1.


Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2018 Nov 1:fj201801594R. doi: 10.1096/fj.201801594R. [Epub ahead of print]


Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons.  J Physiol. 2018 Nov;596(21):5237-5249. doi: 10.1113/JP276720. Epub 2018 Sep 19.


The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling. Hepatology. 2018 Nov;68(5):1817-1832. doi: 10.1002/hep.30102. Epub 2018 Oct 12.


Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2018 Oct 23. doi: 10.1055/s-0038-1673633. [Epub ahead of print]


Early appearance and spread of fast ripples in the hippocampus in a model of cortical traumatic brain injury. J Neurosci. 2018 Oct 17;38(42):9034-9046. doi: 10.1523/JNEUROSCI.3507-17.2018. Epub 2018 Sep 6.


High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway. PLoS One. 2018 Oct 4;13(10):e0199728. doi: 10.1371/journal.pone.0199728. eCollection 2018.


Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors. Commun Biol. 2018 Oct 3;1:159. doi: 10.1038/s42003-018-0157-9. eCollection 2018.


Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices. Arch Toxicol. 2018 Oct;92(10):3191-3205. doi: 10.1007/s00204-018-2295-8. Epub 2018 Aug 24.


Endothelial progenitor cells accelerate endothelial regeneration in an in vitro model of Shigatoxin-2a-induced injury via soluble growth factors. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F861-F869. doi: 10.1152/ajprenal.00633.2017. Epub 2018 Mar 7.


Strategy for marker-based differentiation of pro- and anti-inflammatory macrophages using matrix-assisted laser desorption/ionization mass spectrometry imaging. Analyst. 2018 Sep 10;143(18):4273-4282. doi: 10.1039/c8an00659h. Epub 2018 Jul 20.


Recent advances in hippocampal structure and function. Cell Tissue Res. 2018 Sep;373(3):521-523. doi: 10.1007/s00441-018-2913-z. Epub 2018 Aug 20. doi: 10.1007/s00441-018-2913-z. Editorial. No abstract available.


Electrical coupling between hippocampal neurons: contrasting roles of principal cell gap junctions and interneuron gap junctions. Cell Tissue Res. 2018 Sep;373(3):671-691. doi: 10.1007/s00441-018-2881-3. Epub 2018 Aug 15. Review.


Metabolic modulation of neuronal gamma-band oscillations. Pflugers Arch2018 Sep;470(9):1377-1389. doi: 10.1007/s00424-018-2156-6. Epub 2018 May 28.


The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print]

Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4035
Telefax:+49 6221 54-4038