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Institut für Physiologie und Pathophysiologie

Publications

 

For older publications please refer to the menu in the right-hand column.

 

Marked titles are linked to their respective abstract on a freely accessible external website.

2018

121.

Heinz LP, Kopec W, de Groot BL, Fink RHA. In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways. Sci Rep. 2018 May 2;8(1):6886. doi: 10.1038/s41598-018-25061-z.

2017

120.

Xiyuan Z, Fink RHA, Mosqueira M. NO-sGC Pathway Modulates Ca2+ Release and Muscle Contraction in Zebrafish Skeletal Muscle. Front Physiol. 2017 Aug 23;8:607. doi: 10.3389/fphys.2017.00607. eCollection 2017.

119.

Scheid LM, Weber C, Bopp N, Mosqueira M, Fink RHA. Extraction Protocols for Individual Zebrafish's Ventricle Myosin and Skeletal Muscle Actin for In vitro Motility Assays. Front Physiol. 2017 May 31;8:367. doi: 10.3389/fphys.2017.00367. eCollection 2017.

2016

118.

Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D. Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066. Epub 2016 Mar 24.

117.

Förderer M, Georgiev T, Mosqueira M, Fink RH, Vogel M. Functional second harmonic generation microscopy probes molecular dynamics with high temporal resolution. Biomed Opt Express. 2016 Jan 15;7(2):525-41. doi: 10.1364/BOE.7.000525. eCollection 2016 Feb 1.

116.

Schilling R, Fink RH, Fischer WB. Interaction of ions with the luminal sides of wild-type and mutated skeletal muscle ryanodine receptors. J Mol Model. 2016 Jan;22(1):37. doi: 10.1007/s00894-015-2906-8. Epub 2016 Jan 19.

115.

Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F. Oxidative Stress in Disease and Aging: Mechanisms and Therapies. Oxid Med Cell Longev. 2016;2016:8786564. doi: 10.1155/2016/8786564. Epub 2015 Dec 10.

2015

114.

Georgiev T, Zapiec B, Förderer M, Fink RH, Vogel M. Colocalization properties of elementary Ca2+ release signals with structures specific to the contractile filaments and the tubular system of intact mouse skeletal muscle fibers. J Struct Biol. 2015 Dec;192(3):366-375. doi: 10.1016/j.jsb.2015.09.018. Epub 2015 Oct 21.

113.

Zapiec B, Mombaerts P. Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5873-82. doi: 10.1073/pnas.1512135112. Epub 2015 Oct 8.

112.

Georgiev T, Svirin M, Jaimovich E, Fink RH. Localized nuclear and perinuclear Ca(2+) signals in intact mouse skeletal muscle fibers. Front Physiol. 2015 Sep 29;6:263. doi: 10.3389/fphys.2015.00263. eCollection 2015.

111.

Vogel M, Wingert A, Fink RH, Hagl C, Ganikhanov F, Pfeffer CP. Enabling the detection of UV signal in multimodal nonlinear microscopy with catalogue lens components. J Microsc. 2015 Oct;260(1):62-72. doi: 10.1111/jmi.12267. Epub 2015 May 27.

110.

Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P. S100A1 DNA-based inotropic therapy protects against pro-arrhythmogenic ryanodine receptor 2 dysfunction. Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.

109.

Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E. The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E294-305. doi: 10.1152/ajpendo.00189.2014. Epub 2014 Dec 9.

108.

Wieder N, Fink R, von Wegner F. Exact stochastic simulation of a calcium microdomain reveals the impact of Ca²⁺ fluctuations on IP₃R gating. Biophys J. 2015 Feb 3;108(3):557-67. doi: 10.1016/j.bpj.2014.11.3458.

2014

107.

von Wegner F, Wieder N, Fink RH. Microdomain calcium fluctuations as a colored noise process. Front Genet. 2014 Nov 3;5:376. doi: 10.3389/fgene.2014.00376. eCollection 2014.

106.

Wang YT, Schilling R, Fink RH, Fischer WB. Ion-dynamics in hepatitis C virus p7 helical transmembrane domains - a molecular dynamics simulation study. Biophys Chem. 2014 Aug;192C:33-40. doi: 10.1016/j.bpc.2014.06.001. Epub 2014 Jun 16.

105.

Buttgereit A, Weber C, Friedrich O. A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscul Disord. 2014 Jul;24(7):596-603. doi: 10.1016/j.nmd.2014.04.011. Epub 2014 May 4.

104.

Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M. IL-1α reversibly inhibits skeletal muscle ryanodine receptor. A novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol. 2014 Jun;50(6):1096-106. doi: 10.1165/rcmb.2013-0059OC.

103.

Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1. Nat Commun. 2014 May 2;5:3793. doi: 10.1038/ncomms4793.

102.

Schilling R, Fink RH, Fischer WB. MD simulations of the central pore of ryanodine receptors and sequence comparison with 2B protein from coxsackie virus. Biochim Biophys Acta. 2014 Apr;1838(4):1122-31. doi: 10.1016/j.bbamem.2013.12.008. Epub 2013 Dec 21.


Neue Publikationen

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Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol. 2018 Jul;120:31-41. doi: 10.1016/j.yjmcc.2018.05.010. Epub 2018 May 16.

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Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5556-E5565. doi: 10.1073/pnas.1801366115. Epub 2018 May 23.

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The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print]

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Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons. J Neurochem. 2018 Jun 4. doi: 10.1111/jnc.14479. [Epub ahead of print]

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Metabolic modulation of neuronal gamma-band oscillations. Pflugers Arch. 2018 May 28. doi: 10.1007/s00424-018-2156-6. [Epub ahead of print]

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The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling. Hepatology. 2018 May 23. doi: 10.1002/hep.30102. [Epub ahead of print]

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Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules. Stroke. 2018 Jun;49(6):1479-1487. doi: 10.1161/STROKEAHA.118.020927. Epub 2018 May 14.

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Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1.

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CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients. J Inflamm (Lond). 2018 May 16;15:10. doi: 10.1186/s12950-018-0186-7. eCollection 2018.

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In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways. Sci Rep. 2018 May 2;8(1):6886. doi: 10.1038/s41598-018-25061-z.

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Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. 2018 May;66(5):920-933. doi: 10.1002/glia.23292. Epub 2018 Jan 19.

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Parallel detection of theta and respiration-coupled oscillations throughout the mouse brain. Sci Rep. 2018 Apr 24;8(1):6432. doi: 10.1038/s41598-018-24629-z.

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Endothelial progenitor cells accelerate endothelial regeneration in an in vitro model of Shigatoxin-2a-induced injury via soluble growth factors. Am J Physiol Renal Physiol. 2018 Mar 7. doi: 10.1152/ajprenal.00633.2017. [Epub ahead of print]


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4035
Telefax:+49 6221 54-4038
E-Mail:sekretariat.hecker@
physiologie.uni-heidelberg.de