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Institute of Physiology and Pathophysiology

Publications

 

For older publications please refer to the menu in the right-hand column.

 

Marked titles are linked to their respective abstract on a freely accessible external website.

Prof. Dr. Oliver Kann established his working group in Heidelberg in October 2010.

A complete listing of his work published to date can be found here.

2019

29.

Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E. Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One. 2019 Jan 15;14(1):e0209228. doi: 10.1371/journal.pone.0209228.

28.

Ta TT, Dikmen HO, Schilling S, Chausse B, Lewen A, Hollnagel JO, Kann O. Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19;116(10):4637-4642. doi: 10.1073/pnas.1813562116.

 2018

27.

Berndt N, Rösner J, Haq RU, Kann O, Kovács R, Holzhütter HG, Spies C, Liotta A. Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices. Arch Toxicol. 2018 Oct;92(10):3191-3205. doi: 10.1007/s00204-018-2295-8.

26.

Papageorgiou IE, Valous NA, Lahrmann B, Janova H, Klaft ZJ, Koch A, Schneider UC, Vajkoczy P, Heppner FL, Grabe N, Halama N, Heinemann U, Kann O. Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. 2018 May;66(5):920-933. doi: 10.1002/glia.23292.

25.

Vodovozov W, Schneider J, Elzoheiry S, Hollnagel JO, Lewen A, Kann O. Metabolic modulation of neuronal gamma-band oscillations. Pflugers Arch. 2018 Sep;470(9):1377-1389. doi: 10.1007/s00424-018-2156-6.

2017

24.

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O. Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17740091. doi:
10.1177/0271678X17740091.

23.

Draguhn A, Kann O. "Schmerznerven" - wie aus Schädigungen von Körpergewebe Schmerzen werden. In: Schmerz, lass' nach! Eine Einführung in die Grundbegriffe der Schmerzmedizin. Kirsch J (Ed.), Springer Verlag, 2017, pp 21-29. ISBN: 978-3-662-55257-2.

2016

22.

Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Müller UC, Draguhn A. Amyloid precursor protein protects neuronal network function after hypoxia via control of voltage-gated calcium channels. J Neurosci. 2016 Aug 10;36(32):8356-71. doi: 10.1523/JNEUROSCI.4130-15.2016.

21.

Kann O, Hollnagel JO, Elzoheiry S, Schneider J. Energy and potassium ion homeostasis during gamma oscillations. Front Mol Neurosci. 2016 Jun 16;9:47. doi: 10.3389/fnmol.2016.00047. eCollection 2016.

20.

Kann O. The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis. 2016 Jun;90:75-85. doi: 10.1016/j.nbd.2015.08.005. Epub 2015 Aug 16.

19.

Çalışkan G, Müller I, Semtner M, Winkelmann A, Raza AS, Hollnagel JO, Rösler A, Heinemann U, Stork O, Meier JC. Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence. Cereb Cortex. 2016 May;26(5):2325-40. doi: 10.1093/cercor/bhw001.

18.

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity. 2016 Apr 19;44(4):901-912. doi: 10.1016/j.immuni.2016.04.005.

17.

Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T, Hanisch UK, Kann O. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7. doi: 10.1073/pnas.1513853113. Epub 2015 Dec 22.

2015

16.

Berndt N, Kann O, Holzhütter HG. Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients. J Cereb Blood Flow Metab. J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506. doi: 10.1038/jcbfm.2015.70. Epub 2015 Apr 22.

15.

Schneider J, Lewen A, Ta TT, Galow LV, Isola R, Papageorgiou IE, Kann O. A reliable model for gamma oscillations in hippocampal tissue. J Neurosci Res. 2015 Jul;93(7):1067-78. doi: 10.1002/jnr.23590. Epub 2015 Mar 24.

14.

Papageorgiou IE, Fetani AF, Lewen A, Heinemann U, Kann O. Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration. Brain Struct Funct. 2015 Jul;220(4):2423-39. doi: 10.1007/s00429-014-0802-0. Epub 2014 May 31.

13.

Sandow N, Kim S, Raue C, Päsler D, Klaft ZJ, Antonio LL, Hollnagel JO, Kovacs R, Kann O, Horn P, Vajkoczy P, Holtkamp M, Meencke HJ, Cavalheiro EA, Pragst F, Gabriel S, Lehmann TN, Heinemann U. Drug resistance in cortical and hippocampal slices from resected tissue of epilepsy patients: No significant impact of p-glycoprotein and multidrug resistance-associated proteins. Front Neurol. 2015 Feb 18;6:30. eCollection 2015.


Recent Publications

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Angioneurins-key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury. Prog Neurobiol. 2019 Apr 7. pii: S0301-0082(19)30039-5. doi: 10.1016/j.pneurobio.2019.03.004. [Epub ahead of print] Review.

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Chronic hypoxia changes gene expression profile of primary rat carotid body cells: consequences on the expression of NOS isoforms and ET-1 receptors. Physiol Genomics. 2019 Apr 1;51(4):109-124. doi: 10.1152/physiolgenomics.00114.2018. Epub 2019 Mar 1.

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Determination of the Maximum Velocity of Filaments in the in vitro Motility Assay. Front Physiol. 2019 Mar 27;10:289. doi: 10.3389/fphys.2019.00289. eCollection 2019.

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Marfan syndrome: A therapeutic challenge for long-term care. Biochem Pharmacol. 2019 Mar 26. pii: S0006-2952(19)30120-0. doi: 10.1016/j.bcp.2019.03.034. [Epub ahead of print] Review.

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Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2019 Mar;33(3):3364-3377. doi: 10.1096/fj.201801594R. Epub 2018 Nov 1.

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Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201813562. doi: 10.1073/pnas.1813562116. [Epub ahead of print]

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Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels. Cell Calcium. 2019 Mar;78:66-75. doi: 10.1016/j.ceca.2019.01.002. Epub 2019 Jan 9.

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EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Acta Neuropathol Commun. 2019 Feb 5;7(1):15. doi: 10.1186/s40478-019-0669-7.

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Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2018 Oct 23. doi: 10.1055/s-0038-1673633. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4035
Fax:+49 6221 54-4038
E-mail:sekretariat.hecker@
physiologie.uni-heidelberg.de