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Institute of Physiology and Pathophysiology

Publications

 

For older publications please refer to the menu in the right-hand column.

 

Marked titles are linked to their respective abstract on a freely accessible external website.

Prof. Dr. Oliver Kann established his working group in Heidelberg in October 2010.

A complete listing of his work published to date can be found here.

2019

35.

Kirschbaum E, Haußmann M, Wolf S, Sonntag H, Schneider J, Elzoheiry S, Kann O, Durstewitz D, Hamprecht FA (2019). LeMoNADe: Learned Motif and Neuronal Assembly Detection in calcium imaging videos. In International Conference on Learning Representations (ICLR), Proceedings. 28 pages.

34.

Kann, O., Köhling, R., Speckmann, E.-J. (2019). Gliazellen (Glial cells). In: Physiologie - das Lehrbuch (Physiology - the textbook), 7th ed., Editors: Speckmann, E.-J., Hescheler, J., Köhling, R., Urban & Fischer Verlag/Elsevier GmbH: 49-52. ISBN: 978-3-437-41358-2. [Article in German]

33.

Kann, O., Speckmann, E.-J., Kuschinsky, W. (2019). Blut-Hirn-Schranke, Liquor cerebrospinalis (Blood-brain barrier, cerebrospinal fluid). In: Physiologie - das Lehrbuch (Physiology - the textbook), 7th ed., Editors: Speckmann, E.-J., Hescheler, J., Köhling, R., Urban & Fischer Verlag/Elsevier GmbH: 52-54. ISBN: 978-3-437-41358-2. [Article in German]

32.

Kann, O., Speckmann, E.-J., Kuschinsky, W. (2019). Hirndurchblutung und Energiemetabolismus (Cerebral blood flow and energy metabolism). In: Physiologie - das Lehrbuch (Physiology - the textbook), 7th ed., Editors: Speckmann, E.-J., Hescheler, J., Köhling, R., Urban & Fischer Verlag/Elsevier GmbH: 54-58. ISBN: 978-3-437-41358-2. [Article in German]

31.

Ivens S, Çalışkan G, Papageorgiou I, Cesetti T, Malich A, Kann O, Heinemann U, Stork O, Albrecht A. Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Jul 17. doi: 10.1002/glia.23683.

30.

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O. Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus. J Cereb Blood Flow Metab. 2019 May;39(5):859-873. doi: 10.1177/0271678X17740091.

29.

Chausse B, Kakimoto PA, Caldeira-da-Silva CC, Chaves-Filho AB, Yoshinaga MY, da Silva RP, Miyamoto S, Kowaltowski AJ. Distinct metabolic patterns during microglial remodeling by oleate and palmitate. Biosci Rep. 2019 Apr 5;39(4). pii: BSR20190072. doi: 10.1042/BSR20190072.

28.

Ta TT, Dikmen HO, Schilling S, Chausse B, Lewen A, Hollnagel JO, Kann O. Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19;116(10):4637-4642. doi: 10.1073/pnas.1813562116.

27.

Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E. Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One. 2019 Jan 15;14(1):e0209228. doi: 10.1371/journal.pone.0209228.

 2018

26.

Berndt N, Rösner J, Haq RU, Kann O, Kovács R, Holzhütter HG, Spies C, Liotta A. Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices. Arch Toxicol. 2018 Oct;92(10):3191-3205. doi: 10.1007/s00204-018-2295-8.

25.

Vodovozov W, Schneider J, Elzoheiry S, Hollnagel JO, Lewen A, Kann O. Metabolic modulation of neuronal gamma-band oscillations. Pflugers Arch. 2018 Sep;470(9):1377-1389. doi: 10.1007/s00424-018-2156-6.

24.

Papageorgiou IE, Valous NA, Lahrmann B, Janova H, Klaft ZJ, Koch A, Schneider UC, Vajkoczy P, Heppner FL, Grabe N, Halama N, Heinemann U, Kann O. Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. 2018 May;66(5):920-933. doi: 10.1002/glia.23292.

 2017

23.

Draguhn, A., Kann, O. (2017). "Schmerznerven" - wie aus Schädigungen von Körpergewebe Schmerzen werden ("Pain nerves" - how tissue injury results in pain). In: "Schmerz, lass' nach! Eine Einführung in die Grundbegriffe der Schmerzmedizin", Editor: Kirsch, J., Springer Verlag: 21-29. ISBN: 978-3-662-55257-2. [Article in German]

2016

22.

Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Müller UC, Draguhn A. Amyloid precursor protein protects neuronal network function after hypoxia via control of voltage-gated calcium channels. J Neurosci. 2016 Aug 10;36(32):8356-71. doi: 10.1523/JNEUROSCI.4130-15.2016.

21.

Kann O, Hollnagel JO, Elzoheiry S, Schneider J. Energy and potassium ion homeostasis during gamma oscillations. Front Mol Neurosci. 2016 Jun 16;9:47. doi: 10.3389/fnmol.2016.00047. eCollection 2016.

20.

Kann O. The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis. 2016 Jun;90:75-85. doi: 10.1016/j.nbd.2015.08.005. Epub 2015 Aug 16.

19.

Çalışkan G, Müller I, Semtner M, Winkelmann A, Raza AS, Hollnagel JO, Rösler A, Heinemann U, Stork O, Meier JC. Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence. Cereb Cortex. 2016 May;26(5):2325-40. doi: 10.1093/cercor/bhw001.

18.

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity. 2016 Apr 19;44(4):901-912. doi: 10.1016/j.immuni.2016.04.005.

17.

Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T, Hanisch UK, Kann O. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7. doi: 10.1073/pnas.1513853113. Epub 2015 Dec 22.

2015

16.

Berndt N, Kann O, Holzhütter HG. Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients. J Cereb Blood Flow Metab. J Cereb Blood Flow Metab. 2015 Sep;35(9):1494-506. doi: 10.1038/jcbfm.2015.70. Epub 2015 Apr 22.

15.

Schneider J, Lewen A, Ta TT, Galow LV, Isola R, Papageorgiou IE, Kann O. A reliable model for gamma oscillations in hippocampal tissue. J Neurosci Res. 2015 Jul;93(7):1067-78. doi: 10.1002/jnr.23590. Epub 2015 Mar 24.

14.

Papageorgiou IE, Fetani AF, Lewen A, Heinemann U, Kann O. Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration. Brain Struct Funct. 2015 Jul;220(4):2423-39. doi: 10.1007/s00429-014-0802-0. Epub 2014 May 31.

13.

Sandow N, Kim S, Raue C, Päsler D, Klaft ZJ, Antonio LL, Hollnagel JO, Kovacs R, Kann O, Horn P, Vajkoczy P, Holtkamp M, Meencke HJ, Cavalheiro EA, Pragst F, Gabriel S, Lehmann TN, Heinemann U. Drug resistance in cortical and hippocampal slices from resected tissue of epilepsy patients: No significant impact of p-glycoprotein and multidrug resistance-associated proteins. Front Neurol. 2015 Feb 18;6:30. eCollection 2015.


Recent Publications

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Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

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Simulation Strategies for Calcium Microdomains and Calcium Noise. Adv Exp Med Biol. 2020;1131:771-797. doi: 10.1007/978-3-030-12457-1_31.

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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

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Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. doi: 10.1002/glia.23683. Epub 2019 Jul 17.

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4.2 Kreislauf. In: Physiologie hoch2 (Gründer S, Schlüter KD, eds.) Urban & Fischer Verlag/Elsevier GmbH 2019, pp. 192-225. ISBN 978-3-437-43461-7

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The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain. FASEB J. 2019 Nov;33(11):12812-12824. doi: 10.1096/fj.201901385RR. Epub 2019 Aug 30.

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TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019 Nov;29(11):1038-1048. doi: 10.1002/hipo.23094. Epub 2019 Apr 19.

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The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31.

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Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

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Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells. Life Sci. 2019 Sep 1;232:116620. doi: 10.1016/j.lfs.2019.116620. Epub 2019 Jul 7.

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Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

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Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4035
Fax:+49 6221 54-4038
E-mail:sekretariat.hecker@
physiologie.uni-heidelberg.de