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Pharmakologisches Institut

Publikationen (nur auf englisch verfügbar)


AG Prof. Dr. Jan Siemens

(Sortierung: Aktualität)


Research Articles:

1.       Siemens J, Kamm G: Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center. European Journal of Physiology, 2018.

2.       Rostock C, Schrenk-Siemens K, Pohle J, Siemens J: Human vs. Mouse Nociceptors - Similarities and Differences. Neursoscience 387, 13-27, 2018.

3.       Song K, Wang H, Kamm G, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J: TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science 353, 1393-1398, 2016.

4.       Wang H, Siemens J: TRP ion channels in thermosensation, thermoregulation and metabolism. Temperature, 2, 178-187, DOI:10.1080/23328940.2015.1040604, 2015.

5.       Hanack C, Moroni M, Lima W, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich H, Gassmann M, Roggenkamp D, Bettler B, Lewin G, Selbach M, Siemens J: GABA Blocks Pathological but Not Acute TRPV1 Pain Signals. Cell 160, 759-770, 2015.

6.       Schrenk-Siemens K, Wende H, Prato V, Song S, Rostock R, Loewer A, Utikal J, Lewin G, Lechner S, Siemens J: PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nature Neuroscience 18, 759-770, 2015.

7.       Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF: A somatosensory circuit for cooling perception in mice. Nature Neuroscience 17, 1560-1566, 2014.

8.       Siemens J, Hanack C: Modulation of TRP Ion Channels by Venomous Toxins. Mammalian Transient Receptor Potential (TRP) Cation Channels – Handbook of Experimental Pharmacology 223, 1119-1142, 2014.

9.       Kapp* K, Siemens J*, Häring H-U, Lammers R: Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE. Eur J Cell Biol 91, 687-693, 2012. (*authors contributed equally)

10.    Lechner S, Siemens J: Sensory transduction, the gateway to perception: mechanisms and pathology. Embo Reports 12, 292-295, 2011.


11.    Bohlen C, Priel A, Zhou S, King D, Siemens J*, Julius D*: A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 141, 834-845, 2010. (*authors contributed equally)

12.    McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM: TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 104, 13525-30, 2007.

13.    Trevisani M*, Siemens J*, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P: 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

Proc Natl Acad Sci USA 104, 13519-24, 2007. (*authors contributed equally)

14.    Bautista DM*, Siemens J*, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D: The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204-8, 2007. (*authors contributed equally)

15.    Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D: Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 444, 208-12, 2006.

16.    Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U: Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 428, 950-5, 2004.

17.    Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Müller U: The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Proc Natl Acad Sci USA 99, 14946-51, 2002.