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Pharmakologisches Institut

Publikationen Dr. Stefan Lechner

Research Articles

  1. Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG:
    Touch receptor-derived sensory information alleviates acute pain signalling and fine-tunes nociceptive reflex coordination. Neuron 93, 179-93, 2017
  2. Moshourab R, Frenzel H, Lechner SG, Haseleu J, Bégay V, Omerbašić D, Lewin GR:
    Measurement of vibration detection threshold and tactile spatial acuity in human subjets. J Vis Exp 115, 2016.
    doi: 10.3791/52966
  3. Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J:
    PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nat Neurosci 18, 10-6, 2015
  4. Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR et al.:
    The transcription factor c-Maf controls touch receptor development and function. Science 335, 1373-6, 2012
  5. Heidenreich M*, Lechner SG*, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR:
    KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. (*denotes equal contribution) Nat Neurosci 15, 138-45, 2012
  6. Frenzel H, Bohlender J, Pinsker K, Wohlleben B, Tank J, Lechner SG, Schiska D, Jaijo T, Rüschendorf F, Saar K et al.:
    A genetic basis for mechanosensory traits in humans. PLOS Biol 10, e1001318-754, 2012
  7. Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G et al.:
    Galpha(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153, 184-96, 2012
  8. Lechner SG*, Markworth S*, Poole K, Smith ESJ, Lapatsina L, Frahm S, May M, Pischke S, Suzuki M, Ibañez-Tallon I et al.:
    The molecular and cellular identity of peripheral osmoreceptors. (*denotes equal contribution) Neuron 69, 332-44, 2011
  9. Smith ESJ, Omerbašic D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR:
    The molecular basis of acid insensitivity in the African naked mole-rat. Science 334, 1557-60, 2011
  10. Lechner SG, Frenzel H, Wang R, Lewin GR:
    Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J 28, 1479-91, 2009
  11. Lechner SG, Lewin GR:
    Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. J Physiol 587, 3493-503, 2009
  12. Lechner SG, Hussl S, Schicker KW, Drobny H, Boehm S:
    Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels. Mol Pharmacol 68, 1387-96, 2005
  13. Edelbauer H, Lechner SG, Mayer M, Scholze T, Boehm S:
    Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin. J Neurochem 93, 1110-21, 2005
  14. Lechner SG, Dorostkar MM, Mayer M, Edelbauer H, Pankevych H, Boehm S:
    Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. Eur J Neurosci 20, 2917-28, 2004
  15. Lechner SG, Mayer M, Boehm S:
    Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. J Physiol 553, 789-802, 2003
  16. Kubista H*, Lechner SG*, Wolf AM, Boehm S:
    Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs. (*denotes equal contribution) Br J Pharmacol 138, 343-50, 2003

Reviews and book chapters

  1. Arcourt A, Lechner SG:
    Peripheral and spinal circuits involved in mechanical allodynia. Pain 156, 220-1, 2015
  2. Lewin GR, Lechner SG, Smith ES:
    Nerve growth factor and nociception: From experimental embryology to new analgesic therapy. Handb Exp Pharmacol 220, 251-282, 2014
  3. Lechner SG, Lewin GR:
    Hairy sensation. Physiology (Bethesda) 28, 142-50, 2013
  4. Wende H, Lechner SG, Birchmeier C:
    The transcription factor c-Maf in sensory neuron development. Transcription Nov 1 3(6), 2012
  5. Lechner SG, Siemens J:
    Sensory transduction, the gateway to perception: mechanisms and pathology. EMBO Reports, 2011
  6. Poole K, Lechner SG, Lewin GR:
    The Handbook of touch: The molecular and genetic basis of touch. New York: Spinger Publications, 2011
  7. Lechner SG, Boehm S:
    Regulation of neuronal ion channels via P2Y receptors. Purinergic Signalling 1, 31-41, 2004