Publikationen Dr. Stefan Lechner
Research Articles:
1. Taberner F.J., Prato, V., Schaefer, I., Schrenk-Siemens, K., Heppenstall P.A. & Lechner, S.G.: Structure-guided examination of the mechanogating mechanisms of PIEZO2. PNAS Jun 24. Pii:201905985, 2019. |
2. Schäfer I., Prato V., Arcourt A., Taberner F.J. & Lechner S.G.: Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors. MOL PAIN 14, 1-15, 2018. |
3. Dhandapani, R., Arokiaraj, C.M., Taberner, F.J., Pacifico, P., Raja, S., Nocchi, L., Portulano, C., Franciosa, F., Maffei, M., Hussain, A.F., Reis, F. de C., Reymond, L., Perlas, E., Garcovich, S., Barth, S., Johnsson, K., Lechner, S.G. & Heppenstall, P.A.: Control of mechanical pain hypersensitivity through ligand-targeted photoablation of TrkB positive sensory neurons. NATURE COMMUNICATIONS 9, 1640, 2018. |
4. Narayanan P, Huette M, Kudryasheva G, Taberner F.J., Lechner S.G., Rehfeldt F, Gomez-Varela D, Schmidt M.: Myotubularin related protein-2 and its phosphor-lipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. eLIFE 7, Mar 9, 2018. |
5. Prato V., Taberner F.J., Hockley J.R.F., Callejo G., Arcourt A., Tazir B., Hammer L., Schad P, Heppenstall P.A., Smith E.St.J & Lechner S.G.: Functional and molecular characterization of mechanoinsensitive ‘silent’ nociceptors. CELL REPORTS 21, 3102-3115, 2017. |
6. Arcourt A., Gorham L., Dhandapani R., Prato V., Taberner F.J., Wende H., Gangadharan V., Birchmeier C., Heppenstall P.A. and Lechner S.G.: Touch receptor-derived sensory information alleviates acute mechanical pain and fine-tunes nociceptive reflex coordination. NEURON 93, 179–193, 2017. |
7. Moshourab, R., Frenzel, H., Lechner, S.G., Haseleu, J., Bégay, V., Omerbašić, D., Lewin, G.R.: Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects. J VIS EXP. Sep 1; (115), 2016. |
8. Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. & Birchmeier C.: The transcription factor c-Maf controls touch receptor development and function. Science 335, 1373–1376., 2012. |
9. Heidenreich1, M., Lechner1, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aránguez, G., Moreno-Pelayo, M.Á., Jentsch, T.J., and Lewin, G.R: KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. 1(authors contributed equally) NatURE NeurosciENCE 15, 138–145., 2012. |
10. Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G., Schiska, D., Jaijo, T., Rüschendorf, F., Saar, K., Jordan, J., Millán, J.M., Gross, M. & Lewin G.R.: A Genetic Basis for Mechanosensory Traits in Humans. PLoS BiolOGY 10, e1001318–754., 2012. |
11. Tappe-Theodor, A., Constantin, C.E., Tegeder, I., Lechner, S.G., Langeslag, M., Lepcynzsky, P., Wirotanseng, R.I., Kurejova, M., Agarwal, N., Nagy, G., Todd, A., Wettschureck, N., Offermanns, S., Kress, M., Lewin, G.R. and Kuner, R: Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153, 184–196., 2012. |
12. Smith, E.S.J., Omerbašić, D., Lechner, S.G., Anirudhan, G., Lapatsina, L., & Lewin, G.R.: The molecular basis of acid insensitivity in the African naked mole-rat. Science 334, 1557–1560, 2011. |
13. Lechner, S.G., Frenzel, H., Wang, R. & Lewin, G.R.: Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO JOURNAL 28, 1479–1491, 2009. |
14. Lechner, S.G. & Lewin, G.R.: Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. JOURNAL OF PhysiolOGY - LONDON 587, 3493–3503, 2009. |
15. Lechner, S.G., Hussl, S., Schicker, K.W., Drobny, H. & Boehm, S.: Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels. MolECULAR PharmacolOGY 68, 1387–1396, 2005. |
16. Lechner, S.G., Dorostkar, M.M., Mayer, M., Edelbauer, H., Pankevych, H. & Boehm, S.: Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. EurOPEAN JOURNAL OF NeurosciENCE 20, 2917–28, 2004. |
17. Lechner, S.G., Mayer, M. & Boehm, S.: Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. JOURNAL OF PhysiolOGY - LONDON 553, 789–802, 2003. |
18. Kubista1, H., Lechner1, S.G., Wolf, A.M. & Boehm, S.: Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs. 1(authors contributed equally) BrITISH JOURNAL OF PharmacolOGY 138, 343–350, 2003.
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Reviews, book chapters and online courses:
1. Lechner S.G.: An update on the spinal and peripheral pathways of pain signaling. E-NEUROFORUM 23, 131-136, 2017. |
2. Lechner S.G.: Shedding light on the contribution of different c-fibre nociceptors to nocifensive behaviour. PAIN Dec; 158(12): 2281-2282, 2017. |
3. Arcourt, A. & Lechner, S.G.: Peripheral and spinal circuits involved in mechanical allodynia. PAIN Feb 156(2), 220-1, 2015. |
4. Lewin G.R., Lechner S.G. Smith E.S.: Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy. HandbOOK OF ExpERIMENTAL PharmacolOGY (220):251-82 |
5. Lechner, S.G. & Lewin, G.R.: Hairy sensation. Physiology (Bethesda) 28, 142–150, 2013. |
6. Wende, H., Lechner, S.G. & Birchmeier, C.: The transcription factor c-Maf in sensory neuron development. Transcription Nov 1; 3(6), 303, 2012. |
7. Lechner, S.G. & Siemens, J.: Sensory transduction, the gateway to perception: mechanisms and pathology. EMBO Reports. Apr;12(4):292-5, 2011. |
8. Poole K., Lechner S.G. & Lewin G.R. The Handbook of Touch: The Molecular and Genetic Basis of Touch. New York: Springer Publications 2011 |
9. Lechner, S.G. & Boehm, S.: Regulation of neuronal ion channels via P2Y receptors. Purinergic Signalling 1, 31–41, 2004. |
