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Pharmakologisches Institut

Publikationen Dr. Stefan Lechner

Research Articles:

1.      Taberner F.J., Prato, V., Schaefer, I., Schrenk-Siemens, K., Heppenstall P.A. & Lechner, S.G.: Structure-guided examination of the mechanogating mechanisms of PIEZO2. PNAS Jun 24. Pii:201905985, 2019.

2.       Schäfer I., Prato V., Arcourt A., Taberner F.J. & Lechner S.G.: Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors. MOL PAIN 14, 1-15, 2018.

3.       Dhandapani, R., Arokiaraj, C.M., Taberner, F.J., Pacifico, P., Raja, S., Nocchi, L., Portulano, C., Franciosa, F., Maffei, M., Hussain, A.F., Reis, F. de C., Reymond, L., Perlas, E., Garcovich, S., Barth, S., Johnsson, K., Lechner, S.G. & Heppenstall, P.A.: Control of mechanical pain hypersensitivity through ligand-targeted photoablation of TrkB positive sensory neurons. NATURE COMMUNICATIONS 9, 1640, 2018.

4.       Narayanan P, Huette M, Kudryasheva G, Taberner F.J., Lechner S.G., Rehfeldt F, Gomez-Varela D, Schmidt M.: Myotubularin related protein-2 and its phosphor-lipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. eLIFE 7, Mar 9, 2018.

5.       Prato V., Taberner F.J., Hockley J.R.F., Callejo G., Arcourt A., Tazir B., Hammer L., Schad P, Heppenstall P.A., Smith E.St.J & Lechner S.G.: Functional and molecular characterization of mechanoinsensitive ‘silent’ nociceptors. CELL REPORTS 21, 3102-3115, 2017.

6.       Arcourt A., Gorham L., Dhandapani R., Prato V., Taberner F.J., Wende H., Gangadharan V., Birchmeier C., Heppenstall P.A. and Lechner S.G.: Touch receptor-derived sensory information alleviates acute mechanical pain and fine-tunes nociceptive reflex coordination.  NEURON 93, 179–193, 2017.

7.       Moshourab, R., Frenzel, H., Lechner, S.G., Haseleu, J., Bégay, V., Omerbašić, D., Lewin, G.R.: Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects.  J VIS EXP. Sep 1; (115), 2016.

8.       Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. & Birchmeier C.: The transcription factor c-Maf controls touch receptor development and function. Science 335, 1373–1376., 2012.

9.       Heidenreich1, M., Lechner1, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aránguez, G., Moreno-Pelayo, M.Á., Jentsch, T.J., and Lewin, G.R: KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. 1(authors contributed equally) NatURE NeurosciENCE 15, 138–145., 2012.

10.    Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G., Schiska, D., Jaijo, T., Rüschendorf, F., Saar, K., Jordan, J., Millán, J.M., Gross, M. & Lewin G.R.: A Genetic Basis for Mechanosensory Traits in Humans. PLoS BiolOGY 10, e1001318–754., 2012.

11.    Tappe-Theodor, A., Constantin, C.E., Tegeder, I., Lechner, S.G., Langeslag, M., Lepcynzsky, P., Wirotanseng, R.I., Kurejova, M., Agarwal, N., Nagy, G., Todd, A., Wettschureck, N., Offermanns, S., Kress, M., Lewin, G.R. and Kuner, R: Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153, 184–196., 2012.

12.    Smith, E.S.J., Omerbašić, D., Lechner, S.G., Anirudhan, G., Lapatsina, L., & Lewin, G.R.: The molecular basis of acid insensitivity in the African naked mole-rat. Science 334, 1557–1560, 2011.

13.    Lechner, S.G., Frenzel, H., Wang, R. & Lewin, G.R.: Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO JOURNAL 28, 1479–1491, 2009.

14.    Lechner, S.G. & Lewin, G.R.: Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. JOURNAL OF PhysiolOGY - LONDON 587, 3493–3503, 2009.

15.    Lechner, S.G., Hussl, S., Schicker, K.W., Drobny, H. & Boehm, S.: Presynaptic inhibition via a phospholipase C- and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels. MolECULAR PharmacolOGY 68, 1387–1396, 2005.

16.    Lechner, S.G., Dorostkar, M.M., Mayer, M., Edelbauer, H., Pankevych, H. & Boehm, S.: Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. EurOPEAN JOURNAL OF NeurosciENCE 20, 2917–28, 2004.

17.    Lechner, S.G., Mayer, M. & Boehm, S.: Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. JOURNAL OF PhysiolOGY - LONDON 553, 789–802, 2003.

18.    Kubista1, H., Lechner1, S.G., Wolf, A.M. & Boehm, S.: Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs. 1(authors contributed equally) BrITISH JOURNAL OF PharmacolOGY 138, 343–350, 2003.

 

Reviews, book chapters and online courses:

1.       Lechner S.G.: An update on the spinal and peripheral pathways of pain signaling. E-NEUROFORUM 23, 131-136, 2017.

2.       Lechner S.G.: Shedding light on the contribution of different c-fibre nociceptors to nocifensive behaviour. PAIN Dec; 158(12): 2281-2282, 2017.

3.       Arcourt, A. & Lechner, S.G.: Peripheral and spinal circuits involved in mechanical allodynia. PAIN Feb 156(2), 220-1, 2015.

4.       Lewin G.R., Lechner S.G. Smith E.S.: Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy. HandbOOK OF ExpERIMENTAL PharmacolOGY (220):251-82

5.       Lechner, S.G. & Lewin, G.R.: Hairy sensation. Physiology (Bethesda) 28, 142–150, 2013.

6.       Wende, H., Lechner, S.G. & Birchmeier, C.: The transcription factor c-Maf in sensory neuron development. Transcription Nov 1; 3(6), 303, 2012.

7.       Lechner, S.G. & Siemens, J.: Sensory transduction, the gateway to perception: mechanisms and pathology.            EMBO Reports. Apr;12(4):292-5, 2011.

8.       Poole K., Lechner S.G. &  Lewin G.R. The Handbook of Touch: The Molecular and Genetic Basis of Touch. New York: Springer Publications 2011

9.       Lechner, S.G. & Boehm, S.: Regulation of neuronal ion channels via P2Y receptors. Purinergic Signalling 1, 31–41, 2004.