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Institute of Physiology and Pathophysiology

Research Areas

Using skeletal muscle and neuronal preparations for the development of highly sensitive methods, we are seeking to expand state of the art technology in physical and biophysical sciences to the application in basic medical research.

The techniques used by our group include microscopic fluorescence imaging techniques such as, e.g., confocal/multiphoton imaging, ratiometric wide field fluorescence microscopy, microscopic laser application such as, e.g., UV-laser microdissection and IR-optical tweezers, patch clamp and several other voltage clamp techniques, mathematical modelling of cellular and subcellular dynamic processes, and basic image processing techniques especially for studying dynamic processes.

With the help of this broad spectrum of sensitive techniques many clinical relevant questions can be studied in its molecular origins. For example the investigations on Duchenne muscular dystrophy are utilizing the patch-clamp method and the various approaches for determining the total intracellular calcium turnover in diseased single muscle fibers.

The effects of volatile anaesthetics on the contractile proteins of skeletal and heart muscles, as well as on the ryanodine receptors can be ideally studied using permeabilised muscle fibres, with the contractile force and the calcium turnover as very sensitive indicators of cellular and subcellular effects of volatile anaesthetics.

The research projects of the group are embedded in a network of national and international cooperations, which further expand the interdisciplinary approaches of our research topics. This includes collaborative projects in molecular biology, biotechnology and physical chemistry.

Recent Publications


Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. 2018 Jan 19. doi: 10.1002/glia.23292. [Epub ahead of print]


Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.


Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes. Anal Bioanal Chem. 2018 Jan;410(2):521-528. doi: 10.1007/s00216-017-0748-1. Epub 2017 Nov 16.


Magnolol inhibits venous remodeling in mice. Sci Rep. 2017 Dec 19;7(1):17820. doi: 10.1038/s41598-017-17910-0.


Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2017 Dec 5. pii: fj.201700384RR. doi: 10.1096/fj.201700384RR. [Epub ahead of print]


Role of protein carbonylation in diabetes. J Inherit Metab Dis. 2017 Nov 6. doi: 10.1007/s10545-017-0104-9. [Epub ahead of print]


AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.


Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.


Transcription factor decoy technology: a therapeutic update. Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19. Review.


Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus. J Cereb Blood Flow Metab. 2017 Nov 3; 271678X17740091. doi: 10.1177/0271678X17740091

Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg


Phone:+49 6221 54-4035
Fax:+49 6221 54-4038