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Institut für Physiologie und Pathophysiologie

Dr. rer. nat. Nina D. Ullrich

Publikationsliste

Markierte Titel sind mit dem jeweiligen Abstract auf einer frei zugänglichen Webseite verlinkt.

29.

Rahm AK, Müller ME, Gramlich D, Lugenbiel P, Uludag E, Rivinius R, Ullrich ND, Schmack B, Ruhparwar A, Heimberger T, Weis T, Karck M, Katus HA, Thomas D. Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

28.

Silbernagel N, Körner A, Balitzki J, Jaggy M, Bertels S, Richter B, Hippler M, Hellwig A, Hecker M, Bastmeyer M, Ullrich ND. Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

27.

Schmitt K, Molfenter B, Laureano NK, Tawk B, Bieg M, Hostench XP, Weichenhan D, Ullrich ND, Shang V, Richter D, Stögbauer F, Schroeder L, de Bem Prunes B, Visioli F, Rados PV, Jou A, Plath M, Federspil PA, Thierauf J, Döscher J, Weissinger SE, Hoffmann TK, Wagner S, Wittekindt C, Ishaque N, Eils R, Klussmann JP, Holzinger D, Plass C, Abdollahi A, Freier K, Weichert W, Zaoui K, Hess J. Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

26.

Jiang F, Mohr F, Ullrich ND, Hecker M, Wagner AH. Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

25.

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Nov;32(11):6159-6173. Epub 2018 Jun 7.

24.

Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND. Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol. 2018 Jul;120:31-41. doi: 10.1016/j.yjmcc.2018.05.010. Epub 2018 May 16.

23.

Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D. Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

22.

Srimachai S, Devaux S, Demougeot C, Kumphune S, Ullrich ND, Niggli E, Ingkaninan K, Kamkaew N, Scholfield CN, Tapechum S, Chootip K. Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complement Altern Med. 2017 Feb 20;17(1):117. doi: 10.1186/s12906-017-1637-z.

21.

Sekulic-Jablanovic M, Ullrich ND, Goldblum D, Palmowski-Wolfe A, Zorzato F, Treves S. Functional characterization of orbicularis oculi and extraocular muscles. J Gen Physiol. 2016 May;147(5):395-406. doi: 10.1085/jgp.201511542. Epub 2016 Apr 11.

20.

Kucera JP, Prudat Y, Marcu IC, Azzarito M, Ullrich ND. Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Front Cell Dev Biol. 2015 Sep 24;3:58. eCollection 2015.

19.

Beauchamp P, Moritz W, Kelm JM, Ullrich ND, Agarkova I, Anson B, Suter TM, Zuppinger C. Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.Tissue Eng Part C Methods. 2015 Aug;21(8):852-61. doi: 10.1089/ten.TEC.2014.0376. Epub 2015 Mar 16.

18.

Marcu IC, Illaste A, Heuking P, Jaconi ME, Ullrich ND. Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes. Stem Cells. 2015 Jul;33(7):2208-2218. doi: 10.1002/stem.2009. Epub 2015 May 12.

17.

Dias P, Desplantez T, El-Harasis MA, Chowdhury RA, Ullrich ND, Cabestrero de Diego A, Peters NS, Severs NJ, MacLeod KT, Dupont E. Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line. PLoS One. 2014 Feb 28;9(2):e90266. doi: 10.1371/journal.pone.0090266. eCollection 2014.

16.

Brinks H, Giraud MN, Segiser A, Ferrié C, Longnus S, Ullrich ND, Koch WJ, Most P, Carrel TP, Tevaearai HT. Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. J Heart Lung Transplant. 2014 Feb;33(2):203-10. doi: 10.1016/j.healun.2013.10.006. Epub 2013 Oct 4.

15.

Rokach O, Ullrich ND, Rausch M, Mouly V, Zhou H, Muntoni F, Zorzato F, Treves S. Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization. Biochem J. 2013 Oct 15;455(2):169-77. doi: 10.1042/BJ20130698.

14.

Horn T, Ullrich ND, Egger M. 'Eventless' InsP3-dependent SR-Ca2+ release affecting atrial Ca2+ sparks. J Physiol. 2013 Apr 15;591(Pt 8):2103-11. doi: 10.1113/jphysiol.2012.247288. Epub 2013 Feb 4.

13.

Niggli E, Ullrich ND, Gutierrez D, Kyrychenko S, Poláková E, Shirokova N. Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta. 2013 Apr;1833(4):866-75. doi: 10.1016/j.bbamcr.2012.08.016. Epub 2012 Aug 31. Review.

12.

Kyrychenko S, Poláková E, Kang C, Pocsai K, Ullrich ND, Niggli E, Shirokova N. Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc Res. 2013 Mar 15;97(4):666-75. doi: 10.1093/cvr/cvs425. Epub 2012 Dec 21.

11.

Guex GA, Romano F, Marcu IC, Tevaearai HS, Ullrich ND, Giraud MN. Culture of cardiogenic stem cells on PCL-scaffolds: towards the creation of beating tissue constructs. In: Proceedings of the 10th IASTED International Conference on Biomedical Engineering (791) Biomedical Engineering 2013. Boccaccini AR (Ed.) ACTA Press, Calgary, Canada 2013; DOI: 10.2316/P.2013.791-080.

10.

Ullrich ND, Valdivia HH, Niggli E. PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J Mol Cell Cardiol. 2012 Jul;53(1):33-42. doi: 10.1016/j.yjmcc.2012.03.015. Epub 2012 Apr 1.

9.

Gonzales C, Ullrich ND, Gerber S, Berthonneche C, Niggli E, Pedrazzini T. Isolation of cardiovascular precursor cells from the human fetal heart. Tissue Eng Part A. 2012 Jan;18(1-2):198-207. doi: 10.1089/ten.TEA.2011.0022. Epub 2011 Sep 27.

8.

Ullrich ND, Fischer D, Kornblum C, Walter MC, Niggli E, Zorzato F, Treves S. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Hum Mutat. 2011 Mar;32(3):309-17. doi: 10.1002/humu.21431. Epub 2011 Feb 3.

7.

Ullrich ND, Fanchaouy M, Gusev K, Shirokova N, Niggli E. Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H1992-2003. doi: 10.1152/ajpheart.00602.2009. Epub 2009 Sep 25.

6.

Shkryl VM, Martins AS, Ullrich ND, Nowycky MC, Niggli E, Shirokova N. Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 2009 Sep;458(5):915-28. doi: 10.1007/s00424-009-0670-2. Epub 2009 Apr 22.

5.

Ullrich ND, Krust A, Collins P, MacLeod KT. Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2421-7. doi: 10.1152/ajpheart.01225.2007. Epub 2008 Apr 25.

4.

Ullrich ND, Koschak A, MacLeod KT. Oestrogen directly inhibits the cardiovascular L-type Ca2+ channel Cav1.2. Biochem Biophys Res Commun. 2007 Sep 21;361(2):522-7. Epub 2007 Jul 23.

3.

Tolmachov O, Ma YL, Themis M, Patel P, Spohr H, Macleod KT, Ullrich ND, Kienast Y, Coutelle C, Peters NS. Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc Disord. 2006 Jun 6;6:25.

2.

Ullrich N, Caplanusi A, Brône B, Hermans D, Larivière E, Nilius B, Van Driessche W, Eggermont J. Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral, but not apical, membrane of Caco-2 cells. Am J Physiol Cell Physiol. 2006 May;290(5):C1287-96. Epub 2005 Dec 7.

1.

Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B. Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium. 2005 Mar;37(3):267-78.


Recent Publications

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Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020 Jul 24. doi: 10.1038/s41573-020-0072-x. Online ahead of print.

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Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure. iScience. 2020 Jul 24;23(7):101316. doi: 10.1016/j.isci.2020.101316. Epub 2020 Jun 27.

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A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Int J Mol Sci. 2020 Jul 10;21(14):4887. doi:10.3390/ijms21144887.

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Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. J Neurosci Res. 2020 Jul 7. doi: 10.1002/jnr.24689. Online ahead of print.

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Marfan-Syndrom: Eine therapeutische Herausforderung für die Langzeitbehandlung (3/3). Medinlux. 2020 Jun;6:16-20. Review.

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Amyloid, APP, and Electrical Activity of the Brain. Neuroscientist. 2020 Jun;26(3):231-251. doi: 10.1177/1073858419882619. Epub 2019 Nov 29.

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Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun. 2020 May 21. pii: S0889-1591(20)30209-9. doi: 10.1016/j.bbi.2020.05.052. [Epub ahead of print]

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Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns. Hippocampus. 2020 May 15. doi: 10.1002/hipo.23214. [Epub ahead of print]

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Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells. Front Physiol. 2020 May 8;11:443. doi: 10.3389/fphys.2020.00443. eCollection 2020. Review.

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Plant "intelligence" changes nothing. EMBO Rep. 2020 May 6;21(5):e50395. doi: 10.15252/embr.202050395. Epub 2020 Apr 16.

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Marfan-Syndrom: Eine therapeutische Herausforderung für die Langzeitbehandlung (2/3). Medinlux. 2020 May;5:16-23. Review.

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Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2020 May 1;116(6):1214-1225. doi: 10.1093/cvr/cvz206. Epub 2019 Aug 2.

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Risk and protective factors for post-thrombotic syndrome after deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2020 May;8(3):390-395. doi: 10.1016/j.jvsv.2019.10.012. Epub 2019 Dec 14.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de