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Institute of Physiology and Pathophysiology

apl. Prof. Dr. rer. physiol. Thomas Korff

List of Publications

Marked titles are linked to their respective abstract on a freely accessible website.

Original articles in peer-reviewed journals

62.

Cucuruz B, Kopp R, Pfister K, Noppeney J, Tripal K, Korff T, Zeman F, Koller M, Noppeney T. Risk and protective factors for post-thrombotic syndrome after deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2020 May;8(3):390-395. doi: 10.1016/j.jvsv.2019.10.012. Epub 2019 Dec 14.

61.

Jäger M, De La Torre C, Arnold C, Kohlhaas J, Kappert L, Hecker M, Feldner A, Korff T. Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020 Mar 1;388(1):111782. doi: 10.1016/j.yexcr.2019.111782. Epub 2019 Dec 16.

60.

Klose R, Prinz A, Tetzlaff F, Weis EM, Moll I, Rodriguez-Vita J, Oka C, Korff T, Fischer A. Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Sci Rep. 2019 Dec 3;9(1):18224. doi: 10.1038/s41598-019-54807-6.

59.

Arnold C, Feldner A, Zappe M, Komljenovic D, De La Torre C, Ruzicka P, Hecker M, Neuhofer W, Korff T. Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice. FASEB J. 2019 Mar;33(3):3364-3377. doi: 10.1096/fj.201801594R. Epub 2018 Nov 1.

58.

Ernst AS, Böhler LI, Hagenston AM, Hoffmann A, Heiland S, Sticht C, Bendszus M, Hecker M, Bading H, Marti HH, Korff T, Kunze R. EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Acta Neuropathol Commun. 2019 Feb 5;7(1):15. doi: 10.1186/s40478-019-0669-7.

57.

Arnold C, Korff T. Medikamentöse Varikosetherapie aus der Perspektive experimenteller Modelle. Praxis (Bern 1994). 2019 Jan;108(1):31-36. doi: 10.1024/1661-8157/a003147.

56.

Zappe M, Feldner A, Arnold C, Sticht C, Hecker M, Korff T. NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells. Front Physiol. 2018 Aug 23;9:1190. doi: 10.3389/fphys.2018.01190. eCollection 2018.

55.

Hoffmann A, Dege T, Kunze R, Ernst AS, Lorenz H, Böhler LI, Korff T, Marti HH, Heiland S, Bendszus M, Helluy X, Pham M. Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules. Stroke. 2018 Jun;49(6):1479-1487. doi: 10.1161/STROKEAHA.118.020927. Epub 2018 May 14.

54.

Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T. Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol. 2018 Apr 4;9:320. doi: 10.3389/fphys.2018.00320. eCollection 2018.

53.

Arnold C, Demirel E, Feldner A, Genové G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2018 Apr;32(4):2021-2035. doi: 10.1096/fj.201700384RR. Epub 2018 Jan 5.

52.

Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T. Expansion of functional personalized cells with specific transgene combinations. Nat Commun. 2018 Mar 8;9(1):994. doi: 10.1038/s41467-018-03408-4.

51.

Kuk H, Arnold C, Meyer R, Hecker M, Korff T. Magnolol inhibits venous remodeling in mice. Sci Rep. 2017 Dec 19;7(1):17820. doi: 10.1038/s41598-017-17910-0.

50.

Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bäuerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. 2017 Jul;9(7):890-905. doi: 10.15252/emmm.201606430.

49.

Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovasc Res. 2017 May 1;113(6):681-691. doi: 10.1093/cvr/cvx032.

48.

Pfisterer L, Korff T. Spheroid-Based In Vitro Angiogenesis Model. Methods Mol Biol. 2016;1430:167-77. doi: 10.1007/978-1-4939-3628-1_11.

47.

Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T. Varicose Remodeling of Veins Is Suppressed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors. J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002405. doi: 10.1161/JAHA.115.002405.

46.

Schröder H, Komljenovic D, Hecker M, Korff T. Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle. FASEB J. 2016 Feb;30(2):923-32. doi: 10.1096/fj.15-279240. Epub 2015 Nov 6.

45.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T. Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 2015 Jul;29(7):3076-84. doi: 10.1096/fj.14-267633. Epub 2015 Apr 9.

44.

Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M. Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells. J Am Heart Assoc. 2015 Jun 12;4(6). pii: e001712.

43.

Kunze R, Urrutia A, Hoffmann A, Liu H, Helluy X, Pham M, Reischl S, Korff T, Marti HH. Dimethyl fumarate attenuates cerebral edema formation by protecting the blood-brain barrier integrity. Exp Neurol. 2015 Apr;266:99-111. doi: 10.1016/j.expneurol.2015.02.022. Epub 2015 Feb 25.

42.

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T. TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells. Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014.

41.

 

Pfisterer L, Meyer R, Feldner A, Drews O, Hecker M, Korff T. Bortezomib protects from varicose-like venous remodeling. FASEB J. 2014 Aug;28(8):3518-27. doi: 10.1096/fj.14-250464. Epub 2014 Apr 25.

40.

Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T. EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. Thromb Haemost. 2014 Jul 3;112(1):151-63. doi: 10.1160/TH13-12-1034. Epub 2014 Feb 13.

39.

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T. RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med. 2014 Jun 27;6(8):1075-89. doi: 10.15252/emmm.201403864.

38.

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T. Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc. 2014 Mar 10;3(2):e000626. doi: 10.1161/​JAHA.113.000626.

37.

Korff T, Pfisterer L, Schorpp-Kistner M. miR-663 and the miRaculous Vascular Smooth Muscle Phenotypic Switch. Circ Res. 2013 Oct 25;113(10):1102-5. doi: 10.1161/CIRCRESAHA.113.302578.

36.

Schröder HM, Hoffmann S, Hecker M, Korff T, Ludwig T. The tetraspanin network modulates MT1-MMP cell surface trafficking. Int J Biochem Cell Biol. 2013 Jun;45(6):1133-44. doi: 10.1016/j.biocel.2013.02.020. Epub 2013 Mar 14.

35.

Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A. No Evidence for a Functional Role of Bi-Directional Notch Signaling during Angiogenesis. PLoS One. 2012;7(12):e53074. doi: 10.1371/journal.pone.0053074. Epub 2012 Dec 28.

34.

Pfisterer L, Feldner A, Hecker, M, Korff T. Hypertension impairs myocardin function - a novel mechanism facilitating arterial remodeling. Cardiovasc Res. 2012 Oct 1;96(1):120-9. Epub 2012 Jul 26.

33.

Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ. Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Ther. 2012 Aug;19(8):800-9. Epub 2011 Sep 29.

32.

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M. Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

31.

Navid F, Kolbe L, Stäb F, Korff T, Neufang G. UV-radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells. Exp Dermatol. 2012 Feb;21(2):147-53. doi: 10.1111/j.1600-0625.2011.01416.x. Epub 2011 Dec 6.

30.

Feldner A, Otto H, Rewerk S, Hecker M, Korff T. Experimental hypertension triggers varicosis-like maladaptive venous remodeling through activator protein-1. FASEB J. 2011 Oct;25(10):3613-21. Epub 2011 Jun 17.

29.

Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R, Grau S, Hiraoka N, Eckstein V, Ecker R, Korff T, von Deimling A, Unterberg A, Beckhove P, Herold-Mende CC. Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived transforming growth factor-betas. Clin Cancer Res. 2011 Jul 1;17(13):4296-308. Epub 2011 Apr 8.

28.

Brecht K, Weigert A, Hu J, Popp R, Fisslthaler B, Korff T, Fleming I, Geisslinger G, Brüne B. Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. FASEB J. 2011 Jul;25(7):2408-17. Epub 2011 Mar 30.

27.

Wang Q, Gorbey S, Pfister F, Höger S, Dorn-Beineke A, Krügel K, Berrone E, Wu L, Korff T, Lin J, Busch S, Reichenbach A, Feng Y, Hammes HP. Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic Retinopathy. Cell Physiol Biochem. 2011;27(6):769-82. Epub 2011 Jun 17.

26.

Braun J, Hoffmann SC, Feldner A, Ludwig T, Henning R, Hecker M, Korff T. Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):297-305. Epub 2010 Dec 2.

25.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M. Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 2010 Jul 1;120(7):2307-18. doi: 10.1172/JCI41749. Epub 2010 Jun 14.

24.

Limbourg A, Korff T, Napp LC, Schaper W, Drexler H, Limbourg FP. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc. 2009;4(12):1737-46. Epub 2009 Nov 5.

23.

Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Güldenzoph B, Bermejo JL, Korff T, Hecker M. Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1894-901. Epub 2009 Sep 3.

22.

Laib AM, Bartol A, Alajati A, Korff T, Weber H, Augustin HG. Spheroid-based human endothelial cell microvessel formation in vivo. Nat Protoc. 2009;4(8):1202-15. Epub 2009 Jul 30.

21.

Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, Korff T, Hecker M, Augustin HG. Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. J Cell Sci. 2008 Nov 15;121(Pt 22):3842-50. Epub 2008 Oct 28.

20.

Demicheva E, Hecker M, Korff T. Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis. Circ Res. 2008 Aug 29;103(5):477-84. Epub 2008 Jul 31.

19.

Korff T, Braun J, Pfaff D, Augustin HG, Hecker M. Role of ephrinB2 expression in endothelial cells during arteriogenesis: impact on smooth muscle cell migration and monocyte recruitment. Blood. 2008 Jul 1;112(1):73-81. Epub 2008 Apr 29.

18.

Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M, Augustin HG. Spheroid-based engineering of a human vasculature in mice. Nat Methods. 2008 May;5(5):439-45. Epub 2008 Apr 6.

17.

Webler AC, Popp R, Korff T, Michaelis UR, Urbich C, Busse R, Fleming I. Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1123-9. Epub 2008 Mar 13.

16.

Wirz W, Antoine M, Tag CG, Gressner AM, Korff T, Hellerbrand C, Kiefer P. Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells. Differentiation. 2008 Sep;76(7):784-94. Epub 2008 Jan 3.

15.

Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response. Circulation. 2007 Nov 13;116(20):2288-97. Epub 2007 Oct 29.

14.

Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morawietz H. Flow-dependent regulation of angiopoietin-2. J Cell Physiol. 2008 Feb;214(2):491-503.

13.

Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG. Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context-dependently with CD31. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):468-74. Epub 2005 Dec 15.

12.

Antoine M, Wirz W, Tag CG, Mavituna M, Emans N, Korff T, Stoldt V, Gressner AM, Kiefer P. Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Growth Factors. 2005 Jun;23(2):87-95.

11.

Mayer H, Bertram H, Lindenmaier W, Korff T, Weber H, Weich H. Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation. J Cell Biochem. 2005 Jul 1;95(4):827-39.

10.

Korff T, Krauss T, Augustin HG. Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp Cell Res. 2004 Jul 15;297(2):415-23.

9.

Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marmé D, Augustin HG. Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia. 2004 May-Jun;6(3):248-57.

8.

Liang OD, Korff T, Eckhardt J, Rifaat J, Baal N, Herr F, Preissner KT, Zygmunt M. Oncodevelopmental alpha-fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit. J Clin Endocrinol Metab. 2004 Mar;89(3):1415-22.

7.

Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Petrova T, Jeltsch M, Augustin HG, Alitalo K. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J. 2003 Nov;17(14):2006-13.

6.

Piossek C, Thierauch KH, Schneider-Mergener J, Volkmer-Engert R, Bachmann MF, Korff T, Augustin HG, Germeroth L. Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost. 2003 Sep;90(3):501-10.

5.

Füller T, Korff T, Kilian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci. 2003 Jun 15;116(Pt 12):2461-70. Epub 2003 May 6.

4.

van Royen N, Hoefer I, Buschmann I, Heil M, Kostin S, Deindl E, Vogel S, Korff T, Augustin H, Bode C, Piek JJ, Schaper W. Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation. FASEB J. 2002 Mar;16(3):432-4. Epub 2002 Jan 30.

3.

Korff T, Kimmina S, Martiny-Baron G, Augustin HG. Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J. 2001 Feb;15(2):447-57.

2.

Korff T, Augustin HG. Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci. 1999 Oct;112 ( Pt 19):3249-58.

1.

Korff T, Augustin HG. Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol. 1998 Nov 30;143(5):1341-52.

Reviews in peer-reviewed journals, journal supplements or books; book contributions and books

5.

Pfisterer L, König G, Hecker M, Korff T. Pathogenesis of varicose veins - lessons from biomechanics. Vasa. 2014 March;43(2):88-99.doi: 10.1024/0301-1526/a000335.

4.

Rewerk S, Meyer R, Hecker M, Korff T. Durch die Augen von Laplace: Die Rolle der Wandspannung bei Varikosis. Phlebologie 2012;41(2):61-7

3.

Korff T: Kapitel: „Three dimensional in vitro angiogenesis assays“; Methods in Endothelial Cell Biology (Augustin Ed.), Springer Verlag Heidelberg, ISBN 3-540-21397-X, 2004, pp. 115-124

2.

Korff T: Kapitel: „Three dimensional spheroids culture of endothelial cells“; Methods in Endothelial Cell Biology (Augustin Ed.), Springer Verlag, Heidelberg, ISBN 3-540-21397-X, 2004, pp. 55-62

1.

Korff T: Kapitel: „Alkohol-Wirkung“; Kaffee, Käse, Karies – Biochemie im Alltag (Koolman, Moeller, Röhm, Hrg.), Wiley-VCH Verlag GmbH, ISBN 3-527-29530-5, 1998, pp. 52-70


Recent Publications

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Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

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Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun. 2020 Aug;88:802-814. doi: 10.1016/j.bbi.2020.05.052. Epub 2020 May 21.

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020 Jul 24. doi: 10.1038/s41573-020-0072-x. Online ahead of print.

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Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure. iScience. 2020 Jul 24;23(7):101316. doi: 10.1016/j.isci.2020.101316. Epub 2020 Jun 27.

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A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Int J Mol Sci. 2020 Jul 10;21(14):4887. doi:10.3390/ijms21144887.

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Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. J Neurosci Res. 2020 Jul 7. doi: 10.1002/jnr.24689. Online ahead of print.

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Marfan-Syndrom: Eine therapeutische Herausforderung für die Langzeitbehandlung (3/3). Medinlux. 2020 Jun;6:16-20. Review.

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Amyloid, APP, and Electrical Activity of the Brain. Neuroscientist. 2020 Jun;26(3):231-251. doi: 10.1177/1073858419882619. Epub 2019 Nov 29.

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Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns. Hippocampus. 2020 May 15. doi: 10.1002/hipo.23214. [Epub ahead of print]

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Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells. Front Physiol. 2020 May 8;11:443. doi: 10.3389/fphys.2020.00443. eCollection 2020. Review.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de