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Institute of Physiology and Pathophysiology

Prof. Dr. rer. nat. Markus Hecker

Heidelberg University

Institute of Physiology and Pathophysiology

Department of Cardiovascular Physiologie

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

phone:

+49 6221 54-4036/4035

fax:

+49 6221 54-4038

e-mail:

hecker@physiologie.uni-heidelberg.de

Curriculum Vitae

2015

Co-optation in the Faculty of Biosciences, Heidelberg University, Germany

2012

Specialist of Physiology (German Physiological Society)

since 2012

(alternating biennially) Deputy Managing Director and Managing Director of the Institute of Physiology and Pathophysiology, Heidelberg University, Germany

2006-2011

Managing Director of the Institute of Physiology and Pathophysiology, Heidelberg University, Germany

since 2006

Head of the Division of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, Germany

since 2004

Full Professor (C4) and Director, Institute of Physiology and Pathophysiology, Heidelberg University, Germany

2001-2003

Managing partner, AVONTEC GmbH, Göttingen, Germany

1996-2004

Full Professor (C3) and Head, Department of Cardiovascular Physiology, Göttingen University, Germany

1993-1996

Assistant Professor in the Department of Cardiovascular Physiology, University of Frankfurt, Germany

1993

State doctorate (Dr. rer. nat., habil. in Physiology), Faculty of Medicine, University of Freiburg, Germany

1993

Specialist of Pharmacology (German Society of Experimental and Clinical Pharmacology and Toxicology)

1991-1993

Lecturer in the Department of Applied Physiology, University of Freiburg, Germany

1990-1991

Senior Scientist and Honorary Lecturer, William Harvey Research Institute, St. Bartholomew’s Hospital Medical College, London, UK

1989-1990

Postdoc, William Harvey Research Institute, St. Bartholomew’s Hospital Medical College, London, UK

1988-1989

Postdoc, Department of Physiology and Biophysics, Georgetown University, Washington, DC, USA

1988

Dr. rer. nat. (Ph. D. in Biochemical Pharmacology), University of Konstanz, Germany

1986-1989

Post-graduate in the Research Training Group Biochemical Pharmacology, University of Konstanz, Germany

1985

Diploma (M. Sc. in Biology), University of Konstanz, Germany

1980-1985

Study of Biology, University of Konstanz, Germany

Honors and Awards

2019

Fellow of the American Physiological Society (FAPS)

2003

German Founders Award in the category "Concept" (together with G. Hasenfuss)

2000

Wulf Vater-Dihydropyridine Research Award, Wulf Vater-Foundation (together with M. Cattaruzza, R. Wachter and A.H. Wagner)

1994

Award of the Dr. Heinz und Helene Adam-Foundation for Research on Human Blood and Lymph Vessels

1993

Sandoz Award for therapy-related pharmacological research, German Societey for Experimental and Clinical Pharmacology (togehter with R. Busse, W. Linz and G. Wiemer)


Recent Publications

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Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice. IBRO Rep. 2020 Dec;9:195-206. doi: 10.1016/j.ibror.2020.08.001. eCollection 2020 Dec. Epub 2020 Aug 11.

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Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. J Neurosci Res. 2020 Oct;98(10):1953-1967. doi: 10.1002/jnr.24689. Epub 2020 Jul 7.

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Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns. Hippocampus. 2020 Oct;30(10):1044-1057. doi: 10.1002/hipo.23214. Epub 2020 May 15.

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Processing of hippocampal network activity in the receiver network of the medial entorhinal cortex layer V. J Neurosci. 2020 Sep 25:JN-RM-0586-20. doi: 10.1523/JNEUROSCI.0586-20.2020. Online ahead of print.

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Multifunctional reactive MALDI matrix enabling high-lateral resolution dual polarity MS imaging and lipid C=C position-resolved MS2 imaging. Anal Chem. 2020 Sep 12. doi: 10.1021/acs.analchem.0c03150. Online ahead of print.

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VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations. Neuroscience. 2020 Sep 10:S0306-4522(20)30578-9. doi: 10.1016/j.neuroscience.2020.09.012. Online ahead of print.

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Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2020 Sep 2. doi: 10.1007/s00709-020-01550-9. Online ahead of print.

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020 Sep;19(9):609-633. doi: 10.1038/s41573-020-0072-x. Epub 2020 Jul 24.

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Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2020 Aug 14;S1084-9521(19)30197-1. doi: 10.1016/j.semcdb.2020.08.001. Online ahead of print.

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GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ. J Neuroinflammation. 2020 Aug 11;17(1):235. doi: 10.1186/s12974-020-01903-4.

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Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

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Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun. 2020 Aug;88:802-814. doi: 10.1016/j.bbi.2020.05.052. Epub 2020 May 21.

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Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure. iScience. 2020 Jul 24;23(7):101316. doi: 10.1016/j.isci.2020.101316. Epub 2020 Jun 27.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de