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| Privatdozent Dr. Marco Cattaruzza |
Completely unexpectedly PD Dr. Marco Cattaruzza passed away at the age of 46 on October 27, 2012.
Here, we would like to commemorate our esteemed colleague, a respected scientist and a dedicated teacher.
Following his studies in biology at Goethe University Frankfurt, Marco Cattaruzza worked as a PhD student in the group of Prof. Dr. Claudia Koch-Brandt at the Institute of Pharmacy and Biochemistry, Mainz University, where he studied the expression of the glycoprotein clusterin in apoptotic cells.
After completion of his doctorate he joined the recently founded group of Prof. Dr. Markus Hecker at the Center for Physiology and Pathophysiology at the University of Göttingen in 1996. Here he became particularly interested in the gene regulatory pathways in vascular cells and how they are controlled by biomechanical stimuli such as those exerted by elevated blood pressure. For his work on the vasoprotective effects of anti-hypertensive calcium antagonists he received the Wulf Vater-Dihydropyridine Research Award of Mainz University in 2000, together with Prof. Dr. Markus Hecker, Dr. Rolf Wachter and Dr. Andreas H. Wagner.
In 2004 Marco Cattaruzza was awarded the state doctorate in physiology by the University of Göttingen. In the following year, after the move of Prof. Hecker's entire group to the Institute of Physiology and Pathophysiologiy at Heidelberg University, he became Head of a working group in the Division of Cardiovascular Physiology, where he continued his work on mechanosensing and the sheer stress-dependent regulation of the endothelial nitric oxide synthase 3. With the adhesion protein zyxin, Marco Cattaruzza identified the first mechanosensitive modulator controling the expression of specific genes which are activated by rhythmic stretch.
Marco Cattaruzza was also very actively involved in teaching. As a university instructor he held lectures and supervised lab courses and seminars. A total of 4 science and medical doctoral candidates have worked in his group on their dissertations.
With his research Marco Cattaruzza contributed significantly to our understanding of the role biomechanical influences play during the pathophysiological remodeling of blood vessels. As a scientist he was mainly interested in the basic biological principles, yet he never lost sight of the potential later benefit for patients. It is in this spirit that staff members of the Division continue Marco Cattaruzza's studies.
Publications
Recent Publications
* | Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540 |
* | Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples. Biopreserv Biobank. 2021 Mar 1. doi: 10.1089/bio.2020.0046. Online ahead of print. |
* | Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2021 Mar;258(2):239-248. doi: 10.1007/s00709-020-01550-9. Epub 2020 Sep 2. |
* | Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. PMID: 33630168 |
* | Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021 Feb 15;399(2):112446. doi: 10.1016/j.yexcr.2020.112446. Epub 2021 Jan 7. |
* | A New Apparatus for Recording Evoked Responses to Painful and Non-painful Sensory Stimulation in Freely Moving Mice. Front Neurosci. 2021 Feb 12;15:613801. doi: 10.3389/fnins.2021.613801. eCollection 2021. |
* | Integrated information theory does not make plant consciousness more convincing. Biochem Biophys Res Commun. 2021 Jan 21:S0006-291X(21)00057-7. doi: 10.1016/j.bbrc.2021.01.022. Online ahead of print. |
* | AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Jan 20:cvab012. doi: 10.1093/cvr/cvab012. Online ahead of print. |
* | Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. 2021 Jan 8;4(1):59. doi: 10.1038/s42003-020-01538-4. |
* | A thalamic bridge from sensory perception to cognition. Neurosci Biobehav Rev. 2021 Jan;120:222-235. doi: 10.1016/j.neubiorev.2020.11.013. Epub 2020 Nov 24. |
* | Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group. Lab Anim. 2020 Dec 7:23677220968589. doi: 10.1177/0023677220968589. Online ahead of print. |
* | Pflügers Archiv - European journal of physiology becomes the official journal of the German Physiological Society. 2020 Dec;472(12):1657. doi: 10.1007/s00424-020-02493-z. Editorial. No abstract available. |
* | Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2020 Dec;40(12):2401-2415. doi: 10.1177/0271678X19892657. Epub 2019 Dec 16. |
* | Gene transfer to the vascular system: Novel translational perspectives for vascular diseases. Biochem Pharmacol. 2020 Dec;182:114265. doi: 10.1016/j.bcp.2020.114265. Epub 2020 Oct 6. Review. |
* | Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice. IBRO Rep. 2020 Dec;9:195-206. doi: 10.1016/j.ibror.2020.08.001. eCollection 2020 Dec. Epub 2020 Aug 11. |
* | Debunking a myth: plant consciousness. Protoplasma. 2020 Nov 16. doi: 10.1007/s00709-020-01579-w. Review. Online ahead of print. |
* | Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2020 Aug 14;S1084-9521(19)30197-1. doi: 10.1016/j.semcdb.2020.08.001. Online ahead of print. |
Institute of Heidelberg University Im Neuenheimer Feld 326 69120 Heidelberg Germany
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