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Institute of Pharmacology



Research articles


  1. Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
    Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct non-canonical pathways. Neuron 83:104-121, 2014
  2. Njoo C, Heinl C, Kuner R
    In vivo si RNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice. J Vis Exp Mar 22(85), 2014. doi: 10.3791/51229
  3. Bali KK, Hackenberg M, Lubin A, Kuner R, Devor M
    Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing. Mol Pain 10:22, 2014
  4. Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S
    Genetic dissection of plexin signaling in vivo. PNAS 111:2194-2199, 2014
  5. Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignanon M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A
    BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain 155:556-65, 2014
  6. Wirotanseng LN, Kuner R, Tappe-Theodor A
    Gq rather than G11 preferentially mediates nociceptor sensitization. Mol Pain 9:54, 2013
  7. Kress M, Hüttenhofer A, Landry M, Kuner R, Favereaux A, Greenberg D, Bednarik J, Heppenstall P, Kronenberg F, Malcangio M, Rittner H, Uçeyler N, Trajanoski Z, Mouritzen P, Birklein F, Sommer C, Soreq H
    microRNAs in nociceptive circuits as predictors of future clinical applications. Front Mol Neurosci 6:33, 2013
  8. Bali KK, Venkataramani V, Satagopam VP, Gupta P, Schneider R, Kuner R
    Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by granulocyte-/granulocyte-macrophage colony stimulating factors. Mol Pain 9:48, 2013
  9. Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R, Kuner R
    Genome-wide identification and functional analyses of micro RNA signatures associated with cancer pain. EMBO Mol Med 5:1740-1758, 2013
  10. Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Skoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R
    A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signaling pathways in sensory nerves in vivo. Pain 154:2801-2812, 2013
  11. Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T
    Cannabinoid 1 receptors in kreatinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J Immunol 190:4929-4936, 2013
  12. Simonetti M, Hagenston AM, Vardeh D, Freitag E, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R
    Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron 77, 43-57, 2013
  13. Lu J, Kurejova M, Wirotanseng LN, Linker RA, Kuner R, Tappe-Theodor A
    Pain in experimental autoimmune encephalitis: a comparative study between different mouse models. J Neuroinflammation 9:233, 2012
  14. Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil R, Lewin G, Polgar E, Todd AM, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R
    Presynaptically localized cyclic GMP-dependent Protein Kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol 10(3):e1001283, 2012
  15. Sidiropoulos PN, Miehe M, Bock T, Tinelli E, Oertly CI, Kuner R, Meijer D, Wollscheid B, Niemann A, Suter U
    Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the crucial importance of clathrin-mediated endocytosis in myelination. Brain 135:1395-1411, 2012
  16. Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepczynsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R
    Galpha(q/11) signaling tonically  modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153:184-196, 2012
  17. Tappe-Theodor A, Fu Y, Kuner R, Neugebauer V
    Homer 1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and brain behaviors. Mol Pain 7:38, 2011
  18. Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU
    Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci 31:8134-8142, 2011
  19. Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, Macdermott AB, Lewin GR, Kuner R
    Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest 121:1608-1623, 2011
  20. Li KC, Zhang FX, Li CL, Wang F, Yu MY, Zhong YQ, Zhang KH, Lu YJ, Wang Q, Ma XL, Yao JR, Wang YJ, Lin LB, Han M, Zhang YQ, Kuner R, Xiao HS, Bao L, Gao X, Zhang X
    Follistatin-like 1 suppresses sensory afferent transmission by activating Na(+),K(+)-ATPase. Neuron 69:976-987, 2011
  21. Mair N, Benetti C, Andratsch M, Leitner MG, Constantin CE, Camprubí-Robles M, Quarta S, Biasio W, Kuner R, Gibbins IL, Kress M, Haberberger RV
    Genetic evidence for involvement of neuronally expressed S1P1 receptor in nociceptor sensitization and inflammatory pain. PLoS One 6:e17268, 2011
  22. Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M Dehghani F, Geisslinger G, Tegeder I
    R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One 5:e10628, 2010
  23. Kurejova M, Nattenmüller U, Hildebrandt U, Selvaraj D, Stösser S, Kuner R
    An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain. Mol Pain 6:18, 2010
  24. Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R
    Gene deletion mutants reveal a role for semaphorin receptors of the Plexin-B family in mechanisms underlying corticogenesis. Mol Cell Biol 30:764-780, 2010
  25. Stösser S, Agarwal N, Tappe-Theodor A, Yanagisawa M, Kuner R
    Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion. Pain 148:206-214, 2009
  26. Gangadharan, V, Agarwal N, Brugger S, Tegeder I, Bettler B, Kuner R, Kurejova M,
    Conditional gene deletion reveals functional redundancy of GABA-B receptors in peripheral nociceptors in vivo. Mol Pain 5:68, 2009
  27. Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Vogl C, Sailer CA, Üceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M
    A key role for gp130 expressed on peeripheral sensory nerves in pathological pain. J Neurosci 29(43):13473-13483, 2009
  28. Worzfeld T, Rauch P, Karram K, Trotter J, Kuner R, Offermanns S
    Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci 42:372-381, 2009
  29. Bockhart V, Constantin C, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I
    Inhibitor kappa B kinase beta deficiency in primary nociceptive neurons increases TRP-channel sensitivity. J Neurosci 29(41): 12919-12929, 2009
  30. Vodrazka P, Korostylev A, Swiercz JM, Worzfeld T, Deng S, Fazzari P, Hirschberg A, Tamagnone L, Offermanns S, Kuner R
    The Sema4D-Plexin-B signaling complex regulates dendritic complexity in developing neurons via diverse pathways. Eur J Neurosci 30(7):1193-1208, 2009
  31. Toyoda H, Zhao MG, Ulzhofer B, Wu LJ, Xu H, Seeburg PH, Sprengel R, Kuner R, Zhuo M
    Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activationof ERK in the anterior cingulate cortex. Mol Pain 5:46, 2009
  32. Schweizerhof M, Stösser S, Kurejova M, Njoo C, Gangadharan V, Agarwal N, Schmelz M, Bali KK, Christoph M, Bruggser S, Dickenson A, Simone D, Kuner R
    Hematopoietic colongy stimulating factors mediate tumor-nerve interactions and bone cancer pain. Nat Med 15(7):802-807, 2009
  33. Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL,Anderson DJ, Kuner R, Ma Q
    Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci 28(1):125-132, 2008
  34. Luo C, Seeburg PH, Sprengel R, Kuner R
    Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states. Pain 140(2):358-367, 2008
  35. Schmidtko A, Luo C, Gao W, Geisslinger G, Kuner R, Tegeder I
    Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain 139(3):632-643, 2008
  36. Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R
    A functional role for Semaphorin 4D-Plexin-B1 interactions in epithelial branching morphogenesis during organogenesis. Development 135(20):3333-3343, 2008
  37. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R
    Nociceptor-specific conditional gene deletoin reveals that cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors. Nat Neurosci 10(7):870-879, 2007
  38. Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli ET, Tamagnone L, Offermanns S, Kuner R
    Plexin-B2, but not plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci 27(23):6333-6347, 2007
  39. Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz JM, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R
    A molecular basis of analgesic tolerance to cannabinoids. J Neurosci 27(15): 4165-4177, 2007
  40. Michalski CW, Laukert T, Sauliunaite D, Pacher P, Bergmann F, Agarwal N, Su Y, Giese T, Giese NA, Bátkai S, Friess H, Kuner R
    Cannabinoids ameliorate pain and reduce disease pathology in caerulein-induced acute pancreatitis. Gastroenterology 132(5):1968-1978, 2007
  41. Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB
    Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci USA 104(2): 660-665, 2007
  42. Tappe A, Klugmann M, Luo C, Hirlinger D, Agarwal N, Benrath J, Ehrengruber MU, During MJ, Kuner R
    Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nat Med 12(6): 677-681, 2006
  43. Tappe A, Kuner R
    Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci USA 103(3): 774-779, 2006
  44. Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A, Del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba A
    Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ 13(1): 31-34, 2005
  45. Kuner R, Groom A, Bresink I, Kornau HC, Stefovska V, Müller G, Hartmann B, Tschauner K, Waibel S, Ludolph AC, Ikonomidou C, Seeburg PH, Turski L
    Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit. Proc Natl Acad Sci USA 102(16): 5826-5831, 2005
  46. Dreyer J, Schleicher M, Tappe A, Schilling K, Kuner T, Kusumawidjaja G, Müller-Esterl W, Oess S, Kuner R
    (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. J Neurosci 24(46): 10454-10465, 2004.
  47. Hartmann B, Ahmadi S, Heppenstall P, Zeilhofer HU, Lewin G, Schott C, Seeburg PH, Sprengel R, Kuner R
    The AMPA receptor subunits, GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron 44(4): 637-650, 2004.
  48. Hartmann J, Blum R, Kovalchuk Y, Adelsberger H, Kuner R., Durand GM, Miyata M, Kano M, Offermanns S, Konnerth A
    Distinct roles of Gaq and Ga11 for Purkinje cell signaling and motor behavior. J Neurosci 24(22): 5119-5130, 2004.
  49. Swiercz JM, Kuner R, Offermanns, S
    Plexin-B1/Rho-GEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol 65(6): 869-880, 2004.
  50. Worzfeld T, Püschel A, Offermanns S, Kuner R
    Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: A anatomical basis for morphogenetic effects of Sema4D during development. Eur J Neurosci 19(10): 2622-2632, 2004.
  51. Agarwal N, Offermanns S, Kuner R
    Conditional gene targeting in neurons of the dorsal root ganglia and trigeminal ganglia. Genesis 38(3): 122-129, 2004.
  52. Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M
    Identification of regulated genes during permanent focal cerebral ischemia: Characterization of the protein kinase 9b5/MARKL1/MARK4. J Neurochem 88(5): 1114-1126, 2004.
  53. Kuner R,, Teismann P, Trutzel A, Naim J, Richter A, Schmidt N, Bach A, Ferger B, Schneider A
    TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice. Neurosci Lett 355(1-2): 126-130, 2004.
  54. Kuner R, Teismann P, Trutzel A, Naim J, Richter A, Schmidt N, Ahsen O, Bach A, Ferger B, Schneider A
    TorsinA protects against oxidative stress in COS cells and PC12 cells. Neurosci Lett 350(3): 153-156, 2003.
  55. Dreyer J, Hirlinger D, Müller-Esterl W, Oess S, Kuner R
    Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain. Neurosci Lett 350(1): 13-16, 2003.
  56. Kuner R, Swiercz JM, Zywietz A, Tappe A, Offermanns S
    Characterization of the expression of PDZ-RhoGEF, LARG and Galpha12/Galpha1 proteins in the murine nervous system. Eur J Neurosci. 16(12): 2333-2341, 2002.
  57. Swiercz JM*, Kuner R*, Behrens J, Offermanns S
    Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35(1): 51-63, 2002.
    * equally-contributing authors
  58. Grunewald S, Schupp BJ, Ikeda SR, Kuner R, Steigerwald F, Kornau HC, Kohr G
    Importance of the gamma-aminobutyric acid (B) receptor C-termini for G-protein coupling. Mol Pharmacol 1(5): 1070-1080, 2002.
  59. Kuner R, Kohr G, Grunewald S, Eisenhardt G, Bach A, Kornau HC
    Role of Heteromer formation in GABA-B receptor function. Science 283: 74-77, 1999.
  60. Feldemeyer D, Kask K, Brusa R, Kornau HC, Kolhekar R, Rozov A, Burnashev N, Jensen V, Hvalby O, Sprengel R, Seeburg PH
    Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci 2(1): 57-64, 1999.
  61. Kolhekar R, Murphy S, Gebhart GF
    Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat. Pain 71: 31-40, 1997.
  62. Storck T, Kruth U, Kolhekar R, Sprengel R, Seeburg, PH
    Rapid construction in yeast of complex targeting vectors for gene manipulations in the mouse. Nucleic Acids Res 24(22): 4594-4596, 1996.
  63. Kolhekar R, Gebhart GF
    Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat. J Neurophysiol 75(6): 2344-2353, 1996.
  64. Kolhekar R, Meller ST, Gebhart GF
    NMDA-mediated changes in thermal nociception: allosteric modulation at glycine and polyamine recognition sites. Neuroscience 63: 923-936, 1994.
  65. Kolhekar R, Gebhart GF
    NMDA and quisqualate modulation of visceral nociception in the rat. Brain Res 651: 215-226, 1994.
  66. Kolhekar R, Meller ST, Gebhart GF
    Characterisation of the role of spinal NMDA receptors in thermal nociception in the rat. Neuroscience 57(2): 385-395, 1993.


Reviews and book-chapters

  1. Bali KK, Kuner R
    Noncoding RNAs: key molecules in understanding and treating pain. Trends Mol Med 20:437-448, 2014
  2. Tappe-Theodor A, Kuner R
    Studying ongoing and spontaneous pain in rodents - challenges and opportunities. Eur J Neurosci 39:1881-1890, 2014
  3. Luo C, Kuner T, Kuner R
    Synaptic plasticity in pathological pain. Trends Neurosci 37:343-355, 2014
  4. Heinl C, Kuner R
    Genetic models in pain research. In: Handwerker HO, Arendt-Nielsen L (Eds.): Pain models. IASP Press, pp 61-79, 2013
  5. Gangadharan V, Kuner R
    Pain hypersensitivity mechanisms at a glance. Dis Model Mech 6:889-895, 2013
  6. Stösser S, Schweizerhof M, Kuner R
    Hematopoietic colony-stimulating factors: new players in tumor-nerve interactions. J Mol Med 89:321-329, 2011
  7. Kuner R
    Central mechanisms of pathological pain. Nat Med 16:1258-1266, 2010
  8. Kress M, Kuner R
    Mode of action of cannabinoids on nociceptive nerve endings. Exp Brain Res 196:79-88, 2009
  9. Kuner R
    Genetic approaches for the study of pain. In: Zhuo M, Gebhart GF (Eds.): Molecular Pain. Vol. 1. Higher Education Press, in press
  10. Kuner R, Groom A, Bresink I, Kornau HC, Stefovska V, Müller G, Hartmann B, Tschauner K, Waibel S, Ludolph AC, Ikonomidou C, Seeburg PH, Turski L
    Mechanisms of disease: Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit. Ann NY Acad Sci 1053:269-286, 2005
  11. Gebhart GF, Kuner R, Jones RCW, Bielefeldt K
    Visceral Hypersensitivity. In: Handwerker H, Brune K (Eds): Hyperalgesia: Molecular Mechanisms and clinical implications. IASP Press, Vol. 30, p.87-104, 2004
  12. Kuner R
    Nociception. In: Offermanns S, Rosenthal W (Eds): Encyclopedic Reference of Molecular Pharmacology. Springer Verlag, p. 658, 2003.
  13. Jerecic J, Single F, Kruth U, Krestel H, Kolhekar R, Storck T, Kask K, Higuchi M, Sprengel R, Seeburg PH
    Studies on conditional gene expression in the brain. Ann. N.Y. Acad. Sciences 30; 868: 7-37, 1999.