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Institute of Pharmacology



Research articles


  1. Njoo C, Agarwal N, Lutz B, Kuner R
    The cannabinoid receptor CB1 interacts with the WAVE1 complex and plays a role in actin dynamics and structural plasticity in neurons. PLoS Biol 13(10):e1002286, 2015
  2. Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R
    A functional role for VEGFR1 expressed in peripheral sensory neurons in cancer pain. Cancer Cell 27:780-96, 2015
  3. Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R
    A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun 6:6820, 2015
  4. Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R
    The serine protease inhibitor Serpin A3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med 21:518-23, 2015
  5. Selvaraj D, Kuner R
    Molecular players of tumor-nerve interactions. Pain 156:6-7, 2015
  6. Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R
    Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun 5:5472, 2014
  7. Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J
    Presynaptic GABAergic inhibition regulated by BNDF contributes to neuropathic pain induction. Nat Commun 5:5331,2014
  8. Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
    Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct non-canonical pathways. Neuron 83:104-121, 2014
  9. Njoo C, Heinl C, Kuner R
    In vivo si RNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice. J Vis Exp Mar 22(85), 2014. doi: 10.3791/51229
  10. Bali KK, Hackenberg M, Lubin A, Kuner R, Devor M
    Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing. Mol Pain 10:22, 2014
  11. Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S
    Genetic dissection of plexin signaling in vivo. PNAS 111:2194-2199, 2014
  12. Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignanon M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A
    BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain 155:556-65, 2014
  13. Wirotanseng LN, Kuner R, Tappe-Theodor A
    Gq rather than G11 preferentially mediates nociceptor sensitization. Mol Pain 9:54, 2013
  14. Kress M, Hüttenhofer A, Landry M, Kuner R, Favereaux A, Greenberg D, Bednarik J, Heppenstall P, Kronenberg F, Malcangio M, Rittner H, Uçeyler N, Trajanoski Z, Mouritzen P, Birklein F, Sommer C, Soreq H
    microRNAs in nociceptive circuits as predictors of future clinical applications. Front Mol Neurosci 6:33, 2013
  15. Bali KK, Venkataramani V, Satagopam VP, Gupta P, Schneider R, Kuner R
    Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by granulocyte-/granulocyte-macrophage colony stimulating factors. Mol Pain 9:48, 2013
  16. Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R, Kuner R
    Genome-wide identification and functional analyses of micro RNA signatures associated with cancer pain. EMBO Mol Med 5:1740-1758, 2013
  17. Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Skoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R
    A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signaling pathways in sensory nerves in vivo. Pain 154:2801-2812, 2013
  18. Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T
    Cannabinoid 1 receptors in kreatinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J Immunol 190:4929-4936, 2013
  19. Simonetti M, Hagenston AM, Vardeh D, Freitag E, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R
    Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron 77, 43-57, 2013
  20. Lu J, Kurejova M, Wirotanseng LN, Linker RA, Kuner R, Tappe-Theodor A
    Pain in experimental autoimmune encephalitis: a comparative study between different mouse models. J Neuroinflammation 9:233, 2012
  21. Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil R, Lewin G, Polgar E, Todd AM, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R
    Presynaptically localized cyclic GMP-dependent Protein Kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol 10(3):e1001283, 2012
  22. Sidiropoulos PN, Miehe M, Bock T, Tinelli E, Oertly CI, Kuner R, Meijer D, Wollscheid B, Niemann A, Suter U
    Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the crucial importance of clathrin-mediated endocytosis in myelination. Brain 135:1395-1411, 2012
  23. Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepczynsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R
    Galpha(q/11) signaling tonically  modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153:184-196, 2012
  24. Tappe-Theodor A, Fu Y, Kuner R, Neugebauer V
    Homer 1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and brain behaviors. Mol Pain 7:38, 2011
  25. Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU
    Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci 31:8134-8142, 2011
  26. Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, Macdermott AB, Lewin GR, Kuner R
    Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest 121:1608-1623, 2011
  27. Li KC, Zhang FX, Li CL, Wang F, Yu MY, Zhong YQ, Zhang KH, Lu YJ, Wang Q, Ma XL, Yao JR, Wang YJ, Lin LB, Han M, Zhang YQ, Kuner R, Xiao HS, Bao L, Gao X, Zhang X
    Follistatin-like 1 suppresses sensory afferent transmission by activating Na(+),K(+)-ATPase. Neuron 69:976-987, 2011
  28. Mair N, Benetti C, Andratsch M, Leitner MG, Constantin CE, Camprubí-Robles M, Quarta S, Biasio W, Kuner R, Gibbins IL, Kress M, Haberberger RV
    Genetic evidence for involvement of neuronally expressed S1P1 receptor in nociceptor sensitization and inflammatory pain. PLoS One 6:e17268, 2011
  29. Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M Dehghani F, Geisslinger G, Tegeder I
    R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One 5:e10628, 2010
  30. Kurejova M, Nattenmüller U, Hildebrandt U, Selvaraj D, Stösser S, Kuner R
    An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain. Mol Pain 6:18, 2010
  31. Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R
    Gene deletion mutants reveal a role for semaphorin receptors of the Plexin-B family in mechanisms underlying corticogenesis. Mol Cell Biol 30:764-780, 2010
  32. Stösser S, Agarwal N, Tappe-Theodor A, Yanagisawa M, Kuner R
    Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion. Pain 148:206-214, 2009
  33. Gangadharan, V, Agarwal N, Brugger S, Tegeder I, Bettler B, Kuner R, Kurejova M,
    Conditional gene deletion reveals functional redundancy of GABA-B receptors in peripheral nociceptors in vivo. Mol Pain 5:68, 2009
  34. Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Vogl C, Sailer CA, Üceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M
    A key role for gp130 expressed on peeripheral sensory nerves in pathological pain. J Neurosci 29(43):13473-13483, 2009
  35. Worzfeld T, Rauch P, Karram K, Trotter J, Kuner R, Offermanns S
    Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci 42:372-381, 2009
  36. Bockhart V, Constantin C, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I
    Inhibitor kappa B kinase beta deficiency in primary nociceptive neurons increases TRP-channel sensitivity. J Neurosci 29(41): 12919-12929, 2009
  37. Vodrazka P, Korostylev A, Swiercz JM, Worzfeld T, Deng S, Fazzari P, Hirschberg A, Tamagnone L, Offermanns S, Kuner R
    The Sema4D-Plexin-B signaling complex regulates dendritic complexity in developing neurons via diverse pathways. Eur J Neurosci 30(7):1193-1208, 2009
  38. Toyoda H, Zhao MG, Ulzhofer B, Wu LJ, Xu H, Seeburg PH, Sprengel R, Kuner R, Zhuo M
    Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activationof ERK in the anterior cingulate cortex. Mol Pain 5:46, 2009
  39. Schweizerhof M, Stösser S, Kurejova M, Njoo C, Gangadharan V, Agarwal N, Schmelz M, Bali KK, Christoph M, Bruggser S, Dickenson A, Simone D, Kuner R
    Hematopoietic colongy stimulating factors mediate tumor-nerve interactions and bone cancer pain. Nat Med 15(7):802-807, 2009
  40. Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL,Anderson DJ, Kuner R, Ma Q
    Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci 28(1):125-132, 2008
  41. Luo C, Seeburg PH, Sprengel R, Kuner R
    Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states. Pain 140(2):358-367, 2008
  42. Schmidtko A, Luo C, Gao W, Geisslinger G, Kuner R, Tegeder I
    Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain 139(3):632-643, 2008
  43. Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R
    A functional role for Semaphorin 4D-Plexin-B1 interactions in epithelial branching morphogenesis during organogenesis. Development 135(20):3333-3343, 2008
  44. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R
    Nociceptor-specific conditional gene deletoin reveals that cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors. Nat Neurosci 10(7):870-879, 2007
  45. Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli ET, Tamagnone L, Offermanns S, Kuner R
    Plexin-B2, but not plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci 27(23):6333-6347, 2007
  46. Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz JM, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R
    A molecular basis of analgesic tolerance to cannabinoids. J Neurosci 27(15): 4165-4177, 2007
  47. Michalski CW, Laukert T, Sauliunaite D, Pacher P, Bergmann F, Agarwal N, Su Y, Giese T, Giese NA, Bátkai S, Friess H, Kuner R
    Cannabinoids ameliorate pain and reduce disease pathology in caerulein-induced acute pancreatitis. Gastroenterology 132(5):1968-1978, 2007
  48. Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB
    Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci USA 104(2): 660-665, 2007
  49. Tappe A, Klugmann M, Luo C, Hirlinger D, Agarwal N, Benrath J, Ehrengruber MU, During MJ, Kuner R
    Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nat Med 12(6): 677-681, 2006
  50. Tappe A, Kuner R
    Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci USA 103(3): 774-779, 2006
  51. Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A, Del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba A
    Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ 13(1): 31-34, 2005
  52. Kuner R, Groom A, Bresink I, Kornau HC, Stefovska V, Müller G, Hartmann B, Tschauner K, Waibel S, Ludolph AC, Ikonomidou C, Seeburg PH, Turski L
    Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit. Proc Natl Acad Sci USA 102(16): 5826-5831, 2005
  53. Dreyer J, Schleicher M, Tappe A, Schilling K, Kuner T, Kusumawidjaja G, Müller-Esterl W, Oess S, Kuner R
    (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. J Neurosci 24(46): 10454-10465, 2004.
  54. Hartmann B, Ahmadi S, Heppenstall P, Zeilhofer HU, Lewin G, Schott C, Seeburg PH, Sprengel R, Kuner R
    The AMPA receptor subunits, GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron 44(4): 637-650, 2004.
  55. Hartmann J, Blum R, Kovalchuk Y, Adelsberger H, Kuner R., Durand GM, Miyata M, Kano M, Offermanns S, Konnerth A
    Distinct roles of Gaq and Ga11 for Purkinje cell signaling and motor behavior. J Neurosci 24(22): 5119-5130, 2004.
  56. Swiercz JM, Kuner R, Offermanns, S
    Plexin-B1/Rho-GEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol 65(6): 869-880, 2004.
  57. Worzfeld T, Püschel A, Offermanns S, Kuner R
    Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: A anatomical basis for morphogenetic effects of Sema4D during development. Eur J Neurosci 19(10): 2622-2632, 2004.
  58. Agarwal N, Offermanns S, Kuner R
    Conditional gene targeting in neurons of the dorsal root ganglia and trigeminal ganglia. Genesis 38(3): 122-129, 2004.
  59. Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M
    Identification of regulated genes during permanent focal cerebral ischemia: Characterization of the protein kinase 9b5/MARKL1/MARK4. J Neurochem 88(5): 1114-1126, 2004.
  60. Kuner R,, Teismann P, Trutzel A, Naim J, Richter A, Schmidt N, Bach A, Ferger B, Schneider A
    TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice. Neurosci Lett 355(1-2): 126-130, 2004.
  61. Kuner R, Teismann P, Trutzel A, Naim J, Richter A, Schmidt N, Ahsen O, Bach A, Ferger B, Schneider A
    TorsinA protects against oxidative stress in COS cells and PC12 cells. Neurosci Lett 350(3): 153-156, 2003.
  62. Dreyer J, Hirlinger D, Müller-Esterl W, Oess S, Kuner R
    Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain. Neurosci Lett 350(1): 13-16, 2003.
  63. Kuner R, Swiercz JM, Zywietz A, Tappe A, Offermanns S
    Characterization of the expression of PDZ-RhoGEF, LARG and Galpha12/Galpha1 proteins in the murine nervous system. Eur J Neurosci. 16(12): 2333-2341, 2002.
  64. Swiercz JM*, Kuner R*, Behrens J, Offermanns S
    Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35(1): 51-63, 2002.
    * equally-contributing authors
  65. Grunewald S, Schupp BJ, Ikeda SR, Kuner R, Steigerwald F, Kornau HC, Kohr G
    Importance of the gamma-aminobutyric acid (B) receptor C-termini for G-protein coupling. Mol Pharmacol 1(5): 1070-1080, 2002.
  66. Kuner R, Kohr G, Grunewald S, Eisenhardt G, Bach A, Kornau HC
    Role of Heteromer formation in GABA-B receptor function. Science 283: 74-77, 1999.
  67. Feldemeyer D, Kask K, Brusa R, Kornau HC, Kolhekar R, Rozov A, Burnashev N, Jensen V, Hvalby O, Sprengel R, Seeburg PH
    Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci 2(1): 57-64, 1999.
  68. Kolhekar R, Murphy S, Gebhart GF
    Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat. Pain 71: 31-40, 1997.
  69. Storck T, Kruth U, Kolhekar R, Sprengel R, Seeburg, PH
    Rapid construction in yeast of complex targeting vectors for gene manipulations in the mouse. Nucleic Acids Res 24(22): 4594-4596, 1996.
  70. Kolhekar R, Gebhart GF
    Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat. J Neurophysiol 75(6): 2344-2353, 1996.
  71. Kolhekar R, Meller ST, Gebhart GF
    NMDA-mediated changes in thermal nociception: allosteric modulation at glycine and polyamine recognition sites. Neuroscience 63: 923-936, 1994.
  72. Kolhekar R, Gebhart GF
    NMDA and quisqualate modulation of visceral nociception in the rat. Brain Res 651: 215-226, 1994.
  73. Kolhekar R, Meller ST, Gebhart GF
    Characterisation of the role of spinal NMDA receptors in thermal nociception in the rat. Neuroscience 57(2): 385-395, 1993.


Reviews and book chapters

  1. Kuner R
    Spinal excitatory mechanisms of pathological pain. Pain 156 Suppl 1:S11-7, 2015
  2. Bali KK, Kuner R
    Noncoding RNAs: key molecules in understanding and treating pain. Trends Mol Med 20:437-448, 2014
  3. Tappe-Theodor A, Kuner R
    Studying ongoing and spontaneous pain in rodents - challenges and opportunities. Eur J Neurosci 39:1881-1890, 2014
  4. Luo C, Kuner T, Kuner R
    Synaptic plasticity in pathological pain. Trends Neurosci 37:343-355, 2014
  5. Heinl C, Kuner R
    Genetic models in pain research. In: Handwerker HO, Arendt-Nielsen L (Eds.): Pain models. IASP Press, pp 61-79, 2013
  6. Gangadharan V, Kuner R
    Pain hypersensitivity mechanisms at a glance. Dis Model Mech 6:889-895, 2013
  7. Stösser S, Schweizerhof M, Kuner R
    Hematopoietic colony-stimulating factors: new players in tumor-nerve interactions. J Mol Med 89:321-329, 2011
  8. Kuner R
    Central mechanisms of pathological pain. Nat Med 16:1258-1266, 2010
  9. Kress M, Kuner R
    Mode of action of cannabinoids on nociceptive nerve endings. Exp Brain Res 196:79-88, 2009
  10. Kuner R
    Genetic approaches for the study of pain. In: Zhuo M, Gebhart GF (Eds.): Molecular Pain. Vol. 1. Higher Education Press, in press
  11. Kuner R, Groom A, Bresink I, Kornau HC, Stefovska V, Müller G, Hartmann B, Tschauner K, Waibel S, Ludolph AC, Ikonomidou C, Seeburg PH, Turski L
    Mechanisms of disease: Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit. Ann NY Acad Sci 1053:269-286, 2005
  12. Gebhart GF, Kuner R, Jones RCW, Bielefeldt K
    Visceral Hypersensitivity. In: Handwerker H, Brune K (Eds): Hyperalgesia: Molecular Mechanisms and clinical implications. IASP Press, Vol. 30, p.87-104, 2004
  13. Kuner R
    Nociception. In: Offermanns S, Rosenthal W (Eds): Encyclopedic Reference of Molecular Pharmacology. Springer Verlag, p. 658, 2003.
  14. Jerecic J, Single F, Kruth U, Krestel H, Kolhekar R, Storck T, Kask K, Higuchi M, Sprengel R, Seeburg PH
    Studies on conditional gene expression in the brain. Ann NY Acad Sci 30; 868: 7-37, 1999.