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Institute of Physiology and Pathophysiology

Publications 2010 - 2012

2012

69.

Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A. No Evidence for a Functional Role of Bi-Directional Notch Signaling during Angiogenesis. PLoS One. 2012;7(12):e53074. doi: 10.1371/journal.pone.0053074. Epub 2012 Dec 28.

68.

Djuric Z, Muhammed K, Fleming T, Murikinati S, Piel D, von Bauer R, Bea F, Herzig S,  Zeier M, Liou HC, Pizzi M, Isermann B, Hecker M, Schwaninger M, Bierhaus A, Nawroth PP. Targeting NFκB subunit-specific activation prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012;18(1):1375-86. doi: 10.2119/molmed.2012.00282.

67.

Suresh Babu S, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal. 2012 Dec 11;5(254):ra91. doi: 10.1126/scisignal.2003173

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66.

Cattaruzza M, Nogoy N, Wojtowicz A, Hecker M. Zinc finger motif-1 antagonizes PDGF-BB-induced growth and dedifferentiation of vascular smooth muscle cells. FASEB J. 2012 Dec;26(12):4864-75. Epub 2012 Aug 20.

65.

Drews O. High-resolution separation of cardiovascular proteomes: two-dimensional electrophoresis and liquid chromatography. Circ Cardiovasc Genet. 2012 Oct 1;5(5):592. doi: 10.1161/CIRCGENETICS.110.958637.

64.

Pfisterer L, Feldner A, Hecker, M, Korff T. Hypertension impairs myocardin function - a novel mechanism facilitating arterial remodeling. Cardiovasc Res. 2012 Oct 1;96(1):120-9. Epub 2012 Jul 26.

63.

Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ. Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Ther. 2012 Aug;19(8):800-9. Epub 2011 Sep 29.

62.

Cattaruzza M, Wagner AH, Hecker M. Mechanosensitive pro-inflammatory gene expression in vascular cells. In: Mechanical Stretch and Cytokines, Mechanosensitivity in Cells and Tissues, Vol. 5. A. Kamkin, I. Kiseleva (Eds.) Springer Science+Business Media B. V. 2012, pp. 59-86.

61.

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M. Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res. 2012 Jun 1;94(3):510-8. Epub 2012 Apr 14.

60.

Rewerk S, Meyer R, Hecker M, Korff T. Durch die Augen von Laplace: Die Rolle der Wandspannung bei Varikosis. Phlebologie 2012;41(2):61-7

59.

Stojanovic T, Wagner A, Schöndube FA, Hecker M. Pre-Transplant Therapy in Experimental Heart Transplantation. In: Cardiac Transplantation. Susan D. Moffatt-Bruce (Ed.) InTech. 2012, pp. 143-154. ISBN 978-953-51-0000-3

58.

Navid F, Kolbe L, Stäb F, Korff T, Neufang G. UV-radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells. Exp Dermatol. 2012 Feb;21(2):147-53. doi: 10.1111/j.1600-0625.2011.01416.x. Epub 2011 Dec 6.

2011

57.

Feldner A, Otto H, Rewerk S, Hecker M, Korff T. Experimental hypertension triggers varicosis-like maladaptive venous remodeling through activator protein-1. FASEB J. 2011 Oct;25(10):3613-21. Epub 2011 Jun 17.

56.

Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M. Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells. Blood. 2011 Sep 29;118(13):3734-42. Epub 2011 Aug 10.

55.

Brecht K, Weigert A, Hu J, Popp R, Fisslthaler B, Korff T, Fleming I, Geisslinger G, Brüne B. Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. FASEB J. 2011 Jul;25(7):2408-17. Epub 2011 Mar 30.

54.

Lohr J, Ratliff T, Huppertz A, Ge Y, Dictus C, Ahmadi R, Grau S, Hiraoka N, Eckstein V, Ecker R, Korff T, von Deimling A, Unterberg A, Beckhove P, Herold-Mende CC. Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived transforming growth factor-betas. Clin Cancer Res. 2011 Jul 1;17(13):4296-308. Epub 2011 Apr 8.

53.

Wang Q, Gorbey S, Pfister F, Höger S, Dorn-Beineke A, Krügel K, Berrone E, Wu L, Korff T, Lin J, Busch S, Reichenbach A, Feng Y, Hammes HP. Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic Retinopathy. Cell Physiol Biochem. 2011;27(6):769-82. Epub 2011 Jun 17.

52.

Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H. Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. Basic Res Cardiol. 2011 Jun;106(4):551-61. Epub 2011 Mar 12.

51.

Hoffmann SC, Wabnitz GH, Samstag Y, Moldenhauer G, Ludwig T. Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy. Int J Cancer. 2011 May 1;128(9):2096-104. doi: 10.1002/ijc.25556.

50.

Hoffmann S, Hosseini BH, Hecker M, Louban I, Bulbuc N, Garbi N, Wabnitz GH, Samstag Y, Spatz JP, Hämmerling GJ. Single cell force spectroscopy of T cells recognizing a myelin-derived peptide on antigen presenting cells. Immunol Lett. 2011 Apr 30;136(1):13-20. Epub 2010 Nov 26.

49.

Hoffmann SC, Cohnen A, Ludwig T, Watzl C. 2B4 engagement mediates rapid LFA-1 and actin-dependent NK cell adhesion to tumor cells as measured by single cell force spectroscopy. J Immunol. 2011 Mar 1;186(5):2757-64. Epub 2011 Jan 26.

48.

Braun J, Hoffmann SC, Feldner A, Ludwig T, Henning R, Hecker M, Korff T. Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):297-305. Epub 2010 Dec 2.

2010

47.

Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T. IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. Epub 2010 Aug 13.

46.

Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M. Zyxin mediation of stretch-induced gene expression in human endothelial cells. Circ Res. 2010 Oct 1;107(7):898-902. Epub 2010 Aug 12. Erratum in: Circ Res.2010 Oct 29;107(9):e15-6.

45.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M. Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 2010 Jul 1;120(7):2307-18. Epub 2010 Jun 14.

44.

Lührmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner AH. Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. Exp Lung Res. 2010 Mar;36(2):85-93.

43.

Wagner AH. Physiologie und Pathophysiologie der venösen Hämodynamik. In: Diagnostik und Therapie der Varikose. 1st Edition. Noppeney T, Nüllen  H (Eds.) Springer Berlin Heidelberg 2010, pp. 51-60. ISBN Print 978-3-642-05365-8. ISBN eBook 978-3-642-05366-5.


Recent Publications

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Integrated information theory does not make plant consciousness more convincing. Biochem Biophys Res Commun. 2021 Jul 30;564:166-169. doi: 10.1016/j.bbrc.2021.01.022. Epub 2021 Jan 21.

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Temporal relations between cortical network oscillations and breathing frequency during REM sleep. J Neurosci. 2021 Jun 16;41(24):5229-5242. doi: 10.1523/JNEUROSCI.3067-20.2021. Epub 2021 May 7.

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High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch. Commun Biol. 2021 Jun 10;4(1):709. doi: 10.1038/s42003-021-02241-8.

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AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure. Basic Res Cardiol. 2021 Jun 4;116(1):38. doi: 10.1007/s00395-021-00880-w.

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Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group. Lab Anim. 2021 Jun;55(3):215-232. doi: 10.1177/0023677220968589. Epub 2020 Dec 7.

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Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation. Pharmgenomics Pers Med. 2021 May 20;14:579-590. doi: 10.2147/PGPM.S290291. eCollection 2021.

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TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner. Brain Behav Immun. 2021 May 17:S0889-1591(21)00194-X. doi: 10.1016/j.bbi.2021.05.013. Online ahead of print.

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Mechanobiology of Atherosclerosis. In: Vascular Mechanobiology in Physiology and Disease. Cardiac and Vascular Biology, vol 8. (Hecker M, Duncker DJ, eds.) Springer, Cham 2021, pp. 319-332. Hardcover ISBN 978-3-030-63163-5; eBook ISBN: 978-3-030-63164-2

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The Biomechanics of Venous Remodeling. In: Vascular Mechanobiology in Physiology and Disease. Cardiac and Vascular Biology, vol 8. (Hecker M, Duncker DJ, eds.) Springer, Cham 2021, pp. 167-189. Hardcover ISBN 978-3-030-63163-5; eBook ISBN: 978-3-030-63164-2

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Vascular Mechanobiology in Physiology and Disease. Cardiac and Vascular Biology, vol 8. Springer, Cham 2021, 352 pp. Hardcover ISBN 978-3-030-63163-5; eBook ISBN: 978-3-030-63164-2

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Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue. Mol Ther Methods Clin Dev. 2021 Jun 11;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11.

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Debunking a myth: plant consciousness. Protoplasma. 2021 May;258(3):459-476. doi: 10.1007/s00709-020-01579-w. Epub 2020 Nov 16.

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Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2021 Apr;112:137-144. doi: 10.1016/j.semcdb.2020.08.001. Epub 2020 Aug 15.

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Editorial: Calcium Homeostasis in Skeletal Muscle Function, Plasticity, and Disease. Front Physiol. 2021 Mar 26;12:671292. doi: 10.3389/fphys.2021.671292. eCollection 2021.

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Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn. Acta Physiol (Oxf). 2021 Mar 17:e13647. doi: 10.1111/apha.13647. Online ahead of print.

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Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient. Basic Res Cardiol. 2021 Mar 17;116(1):18. doi: 10.1007/s00395-021-00860-0.

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Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540

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Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples. Biopreserv Biobank. 2021 Mar 1. doi: 10.1089/bio.2020.0046. Online ahead of print.

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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nat Neurosci. 2021 Apr;24(4):529-541. doi: 10.1038/s41593-021-00800-0. Epub 2021 Feb 15.

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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Jan 20:cvab012. doi: 10.1093/cvr/cvab012. Online ahead of print.


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de