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Institute of Physiology and Pathophysiology

Publications 2013 - 2015

2015

95.

Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Carnosine metabolism in diabetes is altered by reactive metabolites. Amino Acids. 2015 Nov;47(11):2367-2376. Epub 2015 Jun 17.

94.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J Mol Cell Cardiol. 2015 Nov;88:111-9. doi: 10.1016/j.yjmcc.2015.10.009. Epub 2015 Oct 9.

93.

Kucera JP, Prudat Y, Marcu IC, Azzarito M, Ullrich ND. Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Front Cell Dev Biol. 2015 Sep 24;3:58. eCollection 2015.

92.

Löffers C, Heilig B, Hecker M. T-786C single nucleotide polymorphism of the endothelial nitric oxide synthase gene as a risk factor for endothelial dysfunction in polymyalgia rheumatica. Clin Exp Rheumatol. 2015 Sep-Oct;33(5):726-30. Epub 2015 Aug 27.

91.

Beauchamp P, Moritz W, Kelm JM, Ullrich ND, Agarkova I, Anson B, Suter TM, Zuppinger C. Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.Tissue Eng Part C Methods. 2015 Aug;21(8):852-61. doi: 10.1089/ten.TEC.2014.0376. Epub 2015 Mar 16.

90.

Marcu IC, Illaste A, Heuking P, Jaconi ME, Ullrich ND. Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes. Stem Cells. 2015 Jul;33(7):2208-2218. doi: 10.1002/stem.2009. Epub 2015 May 12.

89.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T. Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 2015 Jul;29(7):3076-84. doi: 10.1096/fj.14-267633. Epub 2015 Apr 9.

88.

Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M. Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells. J Am Heart Assoc. 2015 Jun 12;4(6). pii: e001712.

87.

Wagner AH, Conzelmann M, Fitzer F, Giese T, Gülow K, Falk CS, Krämer OH, Dietrich S, Hecker M, Luft T. JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter. Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.

86.

Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-Valdes N, Umansky V, Schneider SW. von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood. 2015 May 14;125(20):3153-63. doi: 10.1182/blood-2014-08-595686. Epub 2015 Feb 24.

85.

Möller K, Adolph O, Grünow J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C, Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH, Hecker M. Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells. Thromb Haemost. 2015 May;113(5):1095-108. doi: 10.1160/TH14-04-0336. Epub 2015 Jan 22.

84.

Kunze R, Urrutia A, Hoffmann A, Liu H, Helluy X, Pham M, Reischl S, Korff T, Marti HH. Dimethyl fumarate attenuates cerebral edema formation by protecting the blood-brain barrier integrity. Exp Neurol. 2015 Apr;266:99-111. doi: 10.1016/j.expneurol.2015.02.022. Epub 2015 Feb 25.

83.

Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M. daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans. Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17.

2014

82.

Drews O, Taegtmeyer H. Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies. Antioxid Redox Signal. 2014 Dec 10;21(17):2322-43. doi: 10.1089/ars.2013.5823. Epub 2014 Oct 1.

81.

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T. TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells. Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014.

80.

Wagner AH, Schwarz M, König G, Hecker M. Role of platelet CD40 ligand for endothelial cell-monocyte interaction in the presence of flow. Korea-Aust Rheol J. 2014 Nov;26(4):405-8.

79.

Firasat S, Hecker M, Binder L, Asif AR. Advances in endothelial shear stress proteomics. Expert Rev Proteomics. 2014 Oct;11(5):611-9. doi: 10.1586/14789450.2014.933673. Epub 2014 Jul 12.

78.

Pfisterer L, Meyer R, Feldner A, Drews O, Hecker M, Korff T. Bortezomib protects from varicose-like venous remodeling. FASEB J. 2014 Aug;28(8):3518-27. doi: 10.1096/fj.14-250464. Epub 2014 Apr 25.

77.

Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T. EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. Thromb Haemost. 2014 Jul 3;112(1):151-63. doi: 10.1160/TH13-12-1034. Epub 2014 Feb 13.

76.

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T. RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med. 2014 Jun 27;6(8):1075-89. doi: 10.15252/emmm.201403864.

75.

Drews  O. The left and right ventricle in the grip of protein degradation: Similarities and unique patterns in regulation. J Mol Cell Cardiol. 2014 Jul;72:52-5. doi: 10.1016/j.yjmcc.2014.02.016. Epub 2014 Mar 10.

74.

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T. Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc. 2014 Mar 10;3(2):e000626. doi: 10.1161/​JAHA.113.000626.

73.

Dietrich S, Okun JG, Schmidt K, Falk CS, Wagner AH, Karamustafa S, Radujkovic A, Hegenbart U, Ho AD, Dreger P, Luft T. High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statins. Haematologica. 2014 Mar;99(3):541-7. doi: 10.3324/haematol.2013.090209. Epub 2013 Oct 18.

72.

Pfisterer L, König G, Hecker M, Korff T. Pathogenesis of varicose veins - lessons from biomechanics. Vasa. 2014 March;43(2):88-99.doi: 10.1024/0301-1526/a000335.

2013

71.

Korff T, Pfisterer L, Schorpp-Kistner M. miR-663 and the miRaculous Vascular Smooth Muscle Phenotypic Switch. Circ Res. 2013 Oct 25;113(10):1102-5. doi: 10.1161/CIRCRESAHA.113.302578.

70.

Schröder HM, Hoffmann S, Hecker M, Korff T, Ludwig T. The tetraspanin network modulates MT1-MMP cell surface trafficking. Int J Biochem Cell Biol. 2013 Jun;45(6):1133-44. doi: 10.1016/j.biocel.2013.02.020. Epub 2013 Mar 14.


Recent Publications

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Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue. Mol Ther Methods Clin Dev. 2021 Jun 11;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11.

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Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2021 Apr;112:137-144. doi: 10.1016/j.semcdb.2020.08.001. Epub 2020 Aug 15.

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Editorial: Calcium Homeostasis in Skeletal Muscle Function, Plasticity, and Disease. Front Physiol. 2021 Mar 26;12:671292. doi: 10.3389/fphys.2021.671292. eCollection 2021.

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Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn. Acta Physiol (Oxf). 2021 Mar 17:e13647. doi: 10.1111/apha.13647. Online ahead of print.

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Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient. Basic Res Cardiol. 2021 Mar 17;116(1):18. doi: 10.1007/s00395-021-00860-0.

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Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540

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Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples. Biopreserv Biobank. 2021 Mar 1. doi: 10.1089/bio.2020.0046. Online ahead of print.

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Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2021 Mar;258(2):239-248. doi: 10.1007/s00709-020-01550-9. Epub 2020 Sep 2.

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Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. PMID: 33630168

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Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021 Feb 15;399(2):112446. doi: 10.1016/j.yexcr.2020.112446. Epub 2021 Jan 7.

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A New Apparatus for Recording Evoked Responses to Painful and Non-painful Sensory Stimulation in Freely Moving Mice. Front Neurosci. 2021 Feb 12;15:613801. doi: 10.3389/fnins.2021.613801. eCollection 2021.

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Inhibition of cyclooxygenase activity by diclofenac attenuates varicose remodeling of mouse veins. Vessel Plus 2021 Feb 7;5:7. doi: 10.20517/2574-1209.2020.52.

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Integrated information theory does not make plant consciousness more convincing. Biochem Biophys Res Commun. 2021 Jan 21:S0006-291X(21)00057-7. doi: 10.1016/j.bbrc.2021.01.022. Online ahead of print.

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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Jan 20:cvab012. doi: 10.1093/cvr/cvab012. Online ahead of print.

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Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group. Lab Anim. 2020 Dec 7:23677220968589. doi: 10.1177/0023677220968589. Online ahead of print.

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Debunking a myth: plant consciousness. Protoplasma. 2020 Nov 16. doi: 10.1007/s00709-020-01579-w. Review. Online ahead of print.


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4056
Fax:+49 6221 54-6364
E-mail:susanne.bechtel@
physiologie.uni-heidelberg.de