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Institut für Physiologie und Pathophysiologie

WG Medical Biophysics

Head

Prof. Dr. Alexander Groh

Institute of Physiology and Pathophysiology
INF 326
69120 Heidelberg

Phone:

+49 6221 54-4050

E-Mail:

 groh@uni-heidelberg.de

Our Field of Research

The cerebral cortex is the ‘cognitive’ headquarter of the brain and is instrumental for transforming sensory signals into action. But how does the cortex communicate with the rest of the brain to fulfil this function and how are impairments to this communication expressed in brain diseases? Our lab investigates the structure and the functional mechanisms underlying the interplay between the cortex and subcortical networks that give rise to cognitive functions, including sensori-motor transformations, salience encoding and pathological pain. We are leveraging a combination of in vivo deep-brain electrophysiology, optogenetics, synaptic physiology and behavioural approaches in the mouse model system.

 

Scientists of the division are also integrated in a number of regional and national research centers and networks:   

 


Neue Publikationen

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NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells. Cells. 2021 Nov 24; 10(12):3293. doi: 10.3390/cells10123293

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Comparative lipid profiling of murine and human atherosclerotic plaques using high-resolution MALDI MSI. Pflugers Arch. 2021 Nov 19. doi: doi.org/10.1007/s00424-021-02643-x. Online ahead of print.

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Lin11-Isl1-Mec3 Domain Proteins as Mechanotransducers in Endothelial and Vascular Smooth Muscle Cells. Front Physiol. 2021 Nov 19;12:2066. doi: 10.3389/fphys.2021.769321. eCollection 2021. Review.

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Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals. J Neuroinflammation. 2021 Nov 2;18(1):252. doi: 10.1186/s12974-021-02286-w.

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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Nov 1;117(12):2459-2473. doi: 10.1093/cvr/cvab012.

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Understanding plant behavior: a student perspective: response to Van Volkenburgh et al. Trends Plant Sci. 2021 Nov;26(11):1089-1090. doi: 10.1016/j.tplants.2021.08.014. Epub 2021 Sep 18.

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Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma. Endocr Relat Cancer. 2021 Oct 18;28(12):757-772. doi: 10.1530/ERC-21-0211.

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Neozytolyse: Ein Konzept aus der Raumfahrt konnte in den Schweizer Alpen nicht bestätigt werden. Flug u Reisemed. 2021 Oct;28(5):232-36. doi: 10.1055/a-1524-7894.

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Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure. Life Sci. 2021 Sep 15;281:119769. doi: 10.1016/j.lfs.2021.119769. Epub 2021 Jun 26.

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Transient Oxygen-Glucose Deprivation Causes Region- and Cell Type-Dependent Functional Deficits in the Mouse Hippocampus In Vitro. eNeuro. 2021 Sep 29;8(5):ENEURO.0221-21.2021. doi: 10.1523/ENEURO.0221-21.2021. Print 2021 Sep-Oct.

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Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells. FASEB J. 2021 Sep;35(9):e21831. doi: 10.1096/fj.202100682R.

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Substrate Stiffness Influences Structural and Functional Remodeling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Front Physiol. 2021 Aug 19;12:1306. doi: 10.3389/fphys.2021.710619

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Inverse Regulation of Confluence-Dependent ADAMTS13 and von Willebrand Factor Expression in Human Endothelial Cells. Thromb Haemost. 2021 Aug 5. doi: 10.1055/s-0041-1733800. Online ahead of print.

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Theta-gamma coupling during REM sleep depends on breathing rate. Sleep. 2021 Jul 23:zsab189. doi: 10.1093/sleep/zsab189. Online ahead of print.

Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4056
Telefax:+49 6221 54-6364
E-Mail:susanne.bechtel@
physiologie.uni-heidelberg.de