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Institut für Physiologie und Pathophysiologie

WG Medical Biophysics

Head

Prof. Dr. Alexander Groh

Institute of Physiology and Pathophysiology
INF 326
69120 Heidelberg

Phone:

+49 6221 54-4050

E-Mail:

 groh@uni-heidelberg.de

Our Field of Research

The cerebral cortex is the ‘cognitive’ headquarter of the brain and is instrumental for transforming sensory signals into action. But how does the cortex communicate with the rest of the brain to fulfil this function and how are impairments to this communication expressed in brain diseases? Our lab investigates the structure and the functional mechanisms underlying the interplay between the cortex and subcortical networks that give rise to cognitive functions, including sensori-motor transformations, salience encoding and pathological pain. We are leveraging a combination of in vivo deep-brain electrophysiology, optogenetics, synaptic physiology and behavioural approaches in the mouse model system.

 

Scientists of the division are also integrated in a number of regional and national research centers and networks:   

 


Neue Publikationen

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Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540

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Simulation of Air Travel-Related Irradiation Exposure of Cryopreserved Mouse Germplasm Samples. Biopreserv Biobank. 2021 Mar 1. doi: 10.1089/bio.2020.0046. Online ahead of print.

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Anesthetics and plants: no pain, no brain, and therefore no consciousness. Protoplasma. 2021 Mar;258(2):239-248. doi: 10.1007/s00709-020-01550-9. Epub 2020 Sep 2.

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Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. PMID: 33630168

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Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res. 2021 Feb 15;399(2):112446. doi: 10.1016/j.yexcr.2020.112446. Epub 2021 Jan 7.

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A New Apparatus for Recording Evoked Responses to Painful and Non-painful Sensory Stimulation in Freely Moving Mice. Front Neurosci. 2021 Feb 12;15:613801. doi: 10.3389/fnins.2021.613801. eCollection 2021.

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Integrated information theory does not make plant consciousness more convincing. Biochem Biophys Res Commun. 2021 Jan 21:S0006-291X(21)00057-7. doi: 10.1016/j.bbrc.2021.01.022. Online ahead of print.

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AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome. Cardiovasc Res. 2021 Jan 20:cvab012. doi: 10.1093/cvr/cvab012. Online ahead of print.

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Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. 2021 Jan 8;4(1):59. doi: 10.1038/s42003-020-01538-4.

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A thalamic bridge from sensory perception to cognition. Neurosci Biobehav Rev. 2021 Jan;120:222-235. doi: 10.1016/j.neubiorev.2020.11.013. Epub 2020 Nov 24.

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Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group. Lab Anim. 2020 Dec 7:23677220968589. doi: 10.1177/0023677220968589. Online ahead of print.

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Pflügers Archiv - European journal of physiology becomes the official journal of the German Physiological Society. 2020 Dec;472(12):1657. doi: 10.1007/s00424-020-02493-z. Editorial. No abstract available.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2020 Dec;40(12):2401-2415. doi: 10.1177/0271678X19892657. Epub 2019 Dec 16.

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Gene transfer to the vascular system: Novel translational perspectives for vascular diseases. Biochem Pharmacol. 2020 Dec;182:114265. doi: 10.1016/j.bcp.2020.114265. Epub 2020 Oct 6. Review.

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Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice. IBRO Rep. 2020 Dec;9:195-206. doi: 10.1016/j.ibror.2020.08.001. eCollection 2020 Dec. Epub 2020 Aug 11.

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Debunking a myth: plant consciousness. Protoplasma. 2020 Nov 16. doi: 10.1007/s00709-020-01579-w. Review. Online ahead of print.

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Microglia and lipids: how metabolism controls brain innate immunity. Semin Cell Dev Biol. 2020 Aug 14;S1084-9521(19)30197-1. doi: 10.1016/j.semcdb.2020.08.001. Online ahead of print.


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4056
Telefax:+49 6221 54-6364
E-Mail:susanne.bechtel@
physiologie.uni-heidelberg.de