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Institut für Physiologie und Pathophysiologie

WG Medical Biophysics

Head

Prof. Dr. Alexander Groh

Institute of Physiology and Pathophysiology
INF 326
69120 Heidelberg

Phone:

+49 6221 54-4050

E-Mail:

 groh@uni-heidelberg.de

Our Field of Research

The cerebral cortex is the ‘cognitive’ headquarter of the brain and is instrumental for transforming sensory signals into action. But how does the cortex communicate with the rest of the brain to fulfil this function and how are impairments to this communication expressed in brain diseases? Our lab investigates the structure and the functional mechanisms underlying the interplay between the cortex and subcortical networks that give rise to cognitive functions, including sensori-motor transformations, salience encoding and pathological pain. We are leveraging a combination of in vivo deep-brain electrophysiology, optogenetics, synaptic physiology and behavioural approaches in the mouse model system.

 

 

Scientists of the division are also integrated in a number of regional and national research centers and networks:   


 

 

 


WG Medical Biophysics

Introduction

Research Areas

Group Members

Publications


Neue Publikationen

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AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice. J Heart Lung Transplant. 2020 Apr;39(4):389-398. doi: 10.1016/j.healun.2020.01.1338. Epub 2020 Jan 30.

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Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice. Thromb Haemost. 2020 Mar;120(3):466-476. doi: 10.1055/s-0040-1702228. Epub 2020 Mar 5.

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Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence. Exp Cell Res. 2020 Mar 1;388(1):111782. doi: 10.1016/j.yexcr.2019.111782. Epub 2019 Dec 16.

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Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory. Elife. 2020 Feb 7;9. pii: e49974. doi: 10.7554/eLife.49974.

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Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes. BMC Anesthesiol. 2020 Jan 8;20(1):10. doi: 10.1186/s12871-019-0926-0.

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Factors determining microbial colonization of liquid nitrogen storage tanks used for archiving biological samples. Appl Microbiol Biotechnol. 2020 Jan;104(1):131-144. doi: 10.1007/s00253-019-10242-1. Epub 2019 Nov 28.

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Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

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Simulation Strategies for Calcium Microdomains and Calcium Noise. Adv Exp Med Biol. 2020;1131:771-797. doi: 10.1007/978-3-030-12457-1_31.

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Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations. J Cereb Blood Flow Metab. 2019 Dec 16:271678X19892657. doi: 10.1177/0271678X19892657. [Epub ahead of print

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Risk and protective factors for post-thrombotic syndrome after deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2019 Dec 13. pii: S2213-333X(19)30537-2. doi: 10.1016/j.jvsv.2019.10.012. [Epub ahead of print]

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Amyloid, APP, and Electrical Activity of the Brain. Neuroscientist. 2019 Nov 29:1073858419882619. doi: 10.1177/1073858419882619. [Epub ahead of print]

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The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. J Cereb Blood Flow Metab. 2019 Nov 13:271678X19887777. doi: 10.1177/0271678X19887777. [Epub ahead of print]

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Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovasc Res. 2019 Aug 2. pii: cvz206. doi: 10.1093/cvr/cvz206. [Epub ahead of print]


Institut für
Physiologie und Pathophysiologie

Universität Heidelberg

Im Neuenheimer Feld 326

69120 Heidelberg

Telefon:+49 6221 54-4056
Telefax:+49 6221 54-6364
E-Mail:susanne.bechtel@
physiologie.uni-heidelberg.de