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Institute of Physiology and Pathophysiology

Kann Lab

Head

 

Prof. Dr. med. Oliver Kann

 

Phone:

+49 6221 54-4560

Fax:

+49 6221 54-6364

E-Mail:

oliver.kann@physiologie.uni-heidelberg.de

About us

 

The research in the Kann laboratory has two scientific focuses:

 

1. The human brain has a relatively high energy demand and is very sensitive to shortage of oxygen and glucose. We investigate the neuronal energy metabolism and the functions of mitochondria, in particular during synchronized neuronal network activities that underlie higher brain functions, such as perception and memory, under physiological and pathophysiological conditions.

 

2. The human brain possesses innate immune cells, so-called microglial cells (resident macrophages). Microglia become activated, for example, during injury and infection. We investigate the impact of microglia at different activation stages on neuronal network activities and neurodegeneration.

 

Our basic research provides insights into pathophysiological mechanisms that might have a role in brain diseases, such as multiple sclerosis and Alzheimer's disease.

 

Selected publications:

 

Ta TT, Dikmen HO, Schilling S, Chausse B, Lewen A, Hollnagel JO, Kann O. Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19;116(10):4637-4642. doi: 10.1073/pnas.1813562116.

 

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O. Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17740091. doi: 10.1177/0271678X17740091. [Epub ahead of print]

 

Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T, Hanisch UK, Kann O. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7.

 

Kann O, Huchzermeyer C, Kovács R, Wirtz S, Schuelke M. Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria. Brain. 2011 Feb;134(Pt 2):345-58.

 

Kann O, Kovács R, Njunting M, Behrens CJ, Otáhal J, Lehmann TN, Gabriel S, Heinemann U. Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. Brain. 2005 Oct;128(Pt 10):2396-407. 


Recent Publications

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15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells with a Genetically Determined Nitric Oxide Deficit. Circ Res. 2019 Jun 19. doi: 10.1161/CIRCRESAHA.118.313820. [Epub ahead of print]

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Angioneurins-key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury. Prog Neurobiol. 2019 Jul;178:101611. doi: 10.1016/j.pneurobio.2019.03.004. Epub 2019 Apr 7. Review.

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Marfan syndrome: A therapeutic challenge for long-term care. Biochem Pharmacol. 2019 Jun;164:53-63. doi: 10.1016/j.bcp.2019.03.034. Epub 2019 Mar 27.

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Characterization of the Subventricular-Thalamo-Cortical Circuit in the NP-C Mouse Brain, and New Insights Regarding Treatment. Mol Ther. 2019 May 16. pii: S1525-0016(19)30222-9. doi: 10.1016/j.ymthe.2019.05.008. [Epub ahead of print]

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TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019 Apr 19. doi: 10.1002/hipo.23094. [Epub ahead of print]

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Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201813562. doi: 10.1073/pnas.1813562116. [Epub ahead of print]

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Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model. Thorac Cardiovasc Surg. 2018 Oct 23. doi: 10.1055/s-0038-1673633. [Epub ahead of print]


Institute of
Physiology and Pathophysiology

Heidelberg University

Im Neuenheimer Feld 326

69120 Heidelberg

Germany

Phone:+49 6221 54-4035
Fax:+49 6221 54-4038
E-mail:sekretariat.hecker@
physiologie.uni-heidelberg.de