1 October 1386: Date of foundation of the university by the electoral foundation charter, which also provided for a ''facultas medicinae''.

19 October 1386: Lectures begin. In the first century of the university's existence, the development of the medical faculty progresses very slowly.

1474: The acquisition of two medical books is documented. Although there is no practical teaching, the duration of medical studies is already six years at this time.

from 1558: Ottheinrich's reforms also mark the beginning of a phase of humanistic growth for the Medical Faculty.

1593: The botanical garden is established as the basis for pharmacology, as a herb garden ("hortus medicus"). The garden is one of the oldest in the world.

1686: The physician, anatomist and physiologist Johann Conrad Brunner establishes the first chemical laboratory in the Faculty of Medicine.

1805/06: Opening of the polyclinic. For the first time, medical students had the opportunity to receive systematic practical training on patients.

1818: Opening of the surgical clinic.

1826: Reopening of the polyclinic and strong upswing in clinical-practical medicine in Heidelberg.

1858-1871: Herman (von) Helmholtz is Professor of Physiology and Director of the Institute of Physiology. Helmholtz's appointment separates anatomy and physiology in Heidelberg.

1876-1883: Construction of the clinic on Bergheimer Strasse.

1899/1900: Start of medical studies for women in Heidelberg.

1909: The later philosopher Karl Jaspers is awarded his doctorate in Heidelberg and works as a trainee doctor at the psychiatric clinic from 1909. With his habilitation in psychology (1913), he moves to the Faculty of Philosophy.

1910: Albrecht Kossel receives the Nobel Prize for Medicine.

Since the 1920s: Overall planning and construction of the clinic buildings and institutes in Neuenheimer Feld, e.g. Surgical Clinic 1939, Paediatric Clinic 1966, Theoretical Clinic 1974, Head Clinic 1987, new Medical Clinic 2004. In the long term, all clinics with the exception of the Psychiatric Clinic are to move from the Bergheim site to Neuenheimer Feld and complete the Heidelberg clinic ring.

1933-1945: Medical Faculty under the Nazi dictatorship. More than 20 professors are expelled for so-called "racial" or political reasons. Forced sterilisations are carried out in the Surgery and Women's Clinic. Children from the psychiatric clinic are subjected to so-called "euthanasia", i.e. murdered.

15 August 1945: The Medical Faculty is the first in Heidelberg to resume teaching.

2001: Establishment of the Heidelberg Curriculum Medicinale (HeiCuMed).