Neue Publikationen

Abteilung Funktionelle Neuroanatomie

Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues
Klevanski, M., Herrmannsdörfer, F., Sass, S., Venkataramani, V., Heilemann, M. Kuner, T. (2020). Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues. Nature Communications 11:1552. https://doi.org/10.1038/s41467-020-15362.

Mesopolysaccharides: The extracellular surface layer of visceral organs
Wagner, W.L., Zheng, Y., Pierce, A., Ackermann, M., Horstmann, H., Kuner, T., Ronchi, P., Schwab, Y., Konietzke, P., Wünnemann, F., Wielpütz, M.O., Kauczor, H.-U., and. Mentzer, S.J. (2020). Mesopolysaccharides: The extracellular surface layer of visceral organs. Plos One 15, e0238798.

Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis
Darwisch, W., von Spangenberg, M., Lehmann, J., Singin, Ö., Deubert, G., Kühl, S., Roos, J., Horstmann, H., Körber, C., Hoppe, S., Zheng, H., Kuner, T., Pras-Raves, M.L., van Kampen, A. H. C., Waterham, H., Schwarz, K.V.,  Okun, J. G., Schultz, C., Vaz, F.M., Islinger, M. (2020). The lack of the peroxisome-ER tethering protein ACBD5 induces a complex neurological, cytological and metabolic phenotype in mice. Communications Biology 3, 713.

Strengths and Weaknesses of Non-enhanced and Contrast-enhanced Cadaver Computed Tomography Scans in the Teaching of Gross Anatomy in an Integrated Curriculum
Paech, D., Klopries, K., Nawrotzki, R., Schlemmer, H. -P., Giesel, F.L., Kirsch, J., Schultz, J.-H., Kuner, T. and Doll, S. (2021). Strengths and Weaknesses of Non-enhanced and Contrast-enhanced Cadaver Computed Tomography Scans in the Teaching of Gross Anatomy in an Integrated Curriculum. Anatomical Sciences Education, https://doi.org/10.1002/ase.2034.

Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy
Asan, L., Falfán-Melgoza, C., Beretta, C.A., Sack, M., Zheng, L., Weber-Fahr, W., Kuner, T., and Knabbe, J. (2021). Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy. Scientific Reports 11, 4234.

Visualizing Synaptic Multi-Protein Patterns of Neuronal Tissue With DNA-Assisted Single-Molecule Localization Microscopy
Narayanasamy, K.K., Stojic, A., Li, Y., Sass, S., Hesse, M.R., Deussner-Helfmann, N.S., Dietz, M.S., Kuner, T., Klevanski, M., and Heilemann, M. (2021). Visualizing Synaptic Multi-Protein Patterns of Neuronal Tissue With DNA-Assisted Single-Molecule Localization Microscopy. Frontiers Synaptic Neurosci 13, 671288.

Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids
Grimm, L.M., Sinn, S., Krstić, M., D’Este, E., Sonntag, I., Prasetyanto, E.A., Kuner, T., Wenzel, W., Cola, L.D., and Biedermann, F. (2021). Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids. Adv Mater 2104614.

A synaptic temperature sensor for body cooling
Kamm, G.B., Boffi, J.C., Zuza, K., Nencini, S., Campos, J., Schrenk-Siemens, K., Sonntag, I., Kabaoğlu, B., Hay, M.Y.A.E., Schwarz, Y., Tappe-Theodor, A., Bruns, D., Acuna, C., Kuner, T. & Siemens, J. (2021). A synaptic temperature sensor for body cooling. Neuron 109, 3283-3297.e11.

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
Xie, R.-G., W.-G. Chu, D.-L. Liu, X. Wang, S.-B. Ma, F. Wang, F.-D. Wang, Z. Lin, W.-B. Wu, N. Lu, Y.-Y. Liu, W.-J. Han, H. Zhang, Z.-T. Bai, S.-J. Hu, H.-R. Tao, T. Kuner, X. Zhang, R. Kuner, S.-X. Wu, and C. Luo (2022). Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain. Nat Commun. 13:728. doi:10.1038/s41467-022-28429-y.

Neuropathic pain caused by miswiring and abnormal end organ targeting
Gangadharan, V., H. Zheng, F.J. Taberner, J. Landry, T.A. Nees, J. Pistolic, N. Agarwal, D. Männich, V. Benes, M. Helmstaedter, B. Ommer, S.G. Lechner, T. Kuner, and R. Kuner (2022). Neuropathic pain caused by miswiring and abnormal end organ targeting. Nature 606, 137–145. 10.1038/s41586-022-04777-z.

Glioblastoma hijacks neuronal mechanisms for brain invasion
Venkataramani, V., Y. Yang, M.C. Schubert, E. Reyhan, S.K. Tetzlaff, N. Wißmann, M. Botz, S.J. Soyka, C.A. Beretta, R.L. Pramatarov, L. Fankhauser, L. Garofano, A. Freudenberg, J. Wagner, D.I. Tanev, M. Ratliff, R. Xie, T. Kessler, D.C. Hoffmann, L. Hai, Y. Dörflinger, S. Hoppe, Y.A. Yabo, A. Golebiewska, S.P. Niclou, F. Sahm, A. Lasorella, M. Slowik, L. Döring, A. Iavarone, W. Wick, T. Kuner*, and F. Winkler* (2022). Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. 185:2899-2917.e31. doi:10.1016/j.cell.2022.06.054.

Layer-specific pain relief pathways originating from primary motor cortex
Gan, Z., V. Gangadharan, S. Liu, C. Körber, L.L. Tan, H. Li, M.J. Oswald, J. Kang, J. Martin-Cortecero, D. Männich, A. Groh, T. Kuner, S. Wieland, and R. Kuner (2022). Layer-specific pain relief pathways originating from primary motor cortex. Science. 378:1336–1343. doi:10.1126/science.add4391.

Autonomous rhythmic activity in glioma networks drives brain tumour growth
Hausmann, D., D.C. Hoffmann, V. Venkataramani, E. Jung, S. Horschitz, S.K. Tetzlaff, A. Jabali, L. Hai, T. Kessler, D.D. Azoŕin, S. Weil, A. Kourtesakis, P. Sievers, A. Habel, M.O. Breckwoldt, M.A. Karreman, M. Ratliff, J.M. Messmer, Y. Yang, E. Reyhan, S. Wendler, C. Löb, C. Mayer, K. Figarella, M. Osswald, G. Solecki, F. Sahm, O. Garaschuk, T. Kuner, P. Koch, M. Schlesner, W. Wick, and F. Winkler (2023). Autonomous rhythmic activity in glioma networks drives brain tumour growth. Nature. 613:179–186. doi:10.1038/s41586-022-05520-4.

Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner
Ziegler, K., R. Folkard, A.J. Gonzalez, J. Burghardt, S. Antharvedi-Goda, J. Martin-Cortecero, E. Isaías-Camacho, S. Kaushalya, L.L. Tan, T. Kuner, C. Acuna, R. Kuner, R.A. Mease, and A. Groh (2023). Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner. Nat. Commun. 14:2999. doi:10.1038/s41467-023-38798-7.

Mittal, D., R. Mease, T. Kuner, H. Flor, R. Kuner, and J. Andoh (2023). Data management strategy for a collaborative research center. GigaScience. 12:giad049. doi:10.1093/gigascience/giad049.

2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice
Jauch, I., J. Kamm, L. Benn, L. Rettig, H.-C. Friederich, J. Tesarz, T. Kuner, and S. Wieland (2023). 2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice. eNeuro. 10:ENEURO.0394-22.2023. doi:10.1523/eneuro.0394-22.2023.

Accurate classification of major brain cell types using in vivo imaging and neural network processing
Das Gupta, A., L. Asan, J. John, C. Beretta, T. Kuner*, and J. Knabbe* (2023). Accurate classification of major brain cell types using in vivo imaging and neural network processing. PLOS Biol. 21:e3002357. doi:10.1371/journal.pbio.3002357.

Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A
Klevanski, M., H. Kim, M. Heilemann, T. Kuner*, and R. Bartenschlager* (2024). Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A. Antivir. Res. 225:105856. doi:10.1016/j.antiviral.2024.105856.

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis
Schubert, M.C., S.J. Soyka, A. Tamimi, E. Maus, J. Schroers, N. Wißmann, E. Reyhan, S.K. Tetzlaff, Y. Yang, R. Denninger, R. Peretzke, C. Beretta, M. Drumm, A. Heuer, V. Buchert, A. Steffens, J. Walshon, K. McCortney, S. Heiland, M. Bendszus, P. Neher, A. Golebiewska, W. Wick, F. Winkler, M.O. Breckwoldt, A. Kreshuk, T. Kuner, C. Horbinski, F.T. Kurz, R. Prevedel, and V. Venkataramani. 2024. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis. Nat. Commun. 15:7383. doi:10.1038/s41467-024-51432-4.

Super-Resolved Protein Imaging Using Bifunctional Light-Up Aptamers
Grün, F., N. van den Bergh, M. Klevanski, M.S. Verma, B. Bühler, G.U. Nienhaus, T. Kuner, A. Jäschke, and M. Sunbul. 2024. Super-Resolved Protein Imaging Using Bifunctional Light-Up Aptamers. Angew. Chem. doi:10.1002/ange.202412810.

A tactile discrimination task to study neuronal dynamics in freely-moving mice
Heimburg, F., N.M. Saluti, J. Timm, A. Adlakha, M.H. Bortolozzo-Gleich, J. Martín-Cortecero, M. Castelanelli, M. Klumpp, L. Embray, M. Both, T. Kuner, and A. Groh. 2025. A tactile discrimination task to study neuronal dynamics in freely-moving mice. Nat. Commun. 16:6421. doi:10.1038/s41467-025-61792-0.

High-resolution multimodal imaging reveals spatial and temporal heterogeneity of airway mucus plugging in mice with muco-obstructive lung disease
Benke, C.V., J. Duerr, A. Engel, C. Dullin, W. Stiller, H. Horstmann, C. Redenbach, M. Ackermann, H.-U. Kauczor, T. Kuner, M.O. Wielpütz, M.A. Mall, and W.L. Wagner. 2025. High-resolution multimodal imaging reveals spatial and temporal heterogeneity of airway mucus plugging in mice with muco-obstructive lung disease. Sci. Rep. 15:41760. doi:10.1038/s41598-025-22537-7.

Nanoscale Mapping of the Subcellular Glycosylation Landscape
Schroeter, H.G., S. Sass, M. Heilemann, T. Kuner, and M. Klevanski. 2025. Nanoscale Mapping of the Subcellular Glycosylation Landscape. Adv. Sci. e06731. doi:10.1002/advs.202506731.

Maintenance of a central high frequency synapse in the absence ob synaptic activity
Lessle S, Ebbers L, Dörflinger Y, Hoppe S, Kaiser M, Nothwang HG & Körber C
Front. Cell. Neurosci. 18:1404206, 18 Nov 2024

Glioblastoma hijacks neuronal mechanisms for brain invasion.
Venkataramani V, Yang Y, Schubert MC, Reyhan E, Tetzlaff SK, Wißmann N, Botz M, Soyka SJ, Beretta CA, Pramatarov RL, Fankhauser L, Garofano L, Freudenberg A, Wagner J, Tanev DI, Ratliff M, Xie R, Kessler T, Hoffmann DC, [...] Winkler F
Cell, S0092-8674(22)00847-9, 30 Jul 2022
Cited by: 0 articles | PMID: 35914528

[Post-mortem computed tomography in macroscopic anatomy teaching : Close cooperation between anatomy and radiology].
Klopries K, Tavakoli AA, Doll S, Kuner T, Paech D
Radiologie (Heidelb), 14 Jul 2022
Cited by: 0 articles | PMID: 35838767

Sounding out pain.
Kuner R, Kuner T
Science, 377(6602):155-156, 06 Jul 2022
Cited by: 0 articles | PMID: 35857551

Neuropathic pain caused by miswiring and abnormal end organ targeting.
Gangadharan V, Zheng H, Taberner FJ, Landry J, Nees TA, Pistolic J, Agarwal N, Männich D, Benes V, Helmstaedter M, Ommer B, Lechner SG, Kuner T, Kuner R
Nature, 606(7912):137-145, 24 May 2022
Cited by: 0 articles | PMID: 35614217 | PMCID: PMC9159955

Disconnecting multicellular networks in brain tumours.
Venkataramani V, Schneider M, Giordano FA, Kuner T, Wick W, Herrlinger U, Winkler F
Nat Rev Cancer, 22(8):481-491, 28 Apr 2022
Cited by: 0 articles | PMID: 35488036

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.
Xie RG, Chu WG, Liu DL, Wang X, Ma SB, Wang F, Wang FD, Lin Z, Wu WB, Lu N, Liu YY, Han WJ, Zhang H, Bai ZT, Hu SJ, Tao HR, Kuner T, Zhang X, Kuner R, [...] Luo C
Nat Commun, 13(1):728, 06 Feb 2022
Cited by: 0 articles | PMID: 35132099 | PMCID: PMC8821657

In Vivo Imaging of Axonal Organelle Transport in the Mouse Brain.
Knabbe J, Protzmann J, Kuner T
Methods Mol Biol, 2431:95-109, 31 Dec 2021
Cited by: 0 articles | PMID: 35412273

Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences.
Wichmann C, Kuner T
Physiol Rev, 102(1):269-318, 31 Dec 2021
Cited by: 2 articles | PMID: 34727002

A synaptic temperature sensor for body cooling.
Kamm GB, Boffi JC, Zuza K, Nencini S, Campos J, Schrenk-Siemens K, Sonntag I, Kabaoğlu B, El Hay MYA, Schwarz Y, Tappe-Theodor A, Bruns D, Acuna C, Kuner T, Siemens J
Neuron, 109(20):3283-3297.e11, 30 Sep 2021
Cited by: 0 articles | PMID: 34672983 | PMCID: PMC7613177

Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids.
Grimm LM, Sinn S, Krstić M, D'Este E, Sonntag I, Prasetyanto EA, Kuner T, Wenzel W, De Cola L, Biedermann F
Adv Mater, 33(49):e2104614, 26 Sep 2021
Cited by: 1 article | PMID: 34580934

Visualizing Synaptic Multi-Protein Patterns of Neuronal Tissue With DNA-Assisted Single-Molecule Localization Microscopy.
Narayanasamy KK, Stojic A, Li Y, Sass S, Hesse MR, Deussner-Helfmann NS, Dietz MS, Kuner T, Klevanski M, Heilemann M
Front Synaptic Neurosci, 13:671288, 16 Jun 2021
Cited by: 1 article | PMID: 34220481 | PMCID: PMC8247585

Strengths and Weaknesses of Non-enhanced and Contrast-enhanced Cadaver Computed Tomography Scans in the Teaching of Gross Anatomy in an Integrated Curriculum.
Paech D, Klopries K, Nawrotzki R, Schlemmer HP, Giesel FL, Kirsch J, Schultz JH, Kuner T, Doll S
Anat Sci Educ, 15(1):143-154, 23 Feb 2021
Cited by: 1 article | PMID: 33170986

Visualizing multi-protein patterns at the synapse of neuronal tissue with DNA-assisted single-molecule localization microscopy
Narayanasamy KK, Stojic A, Li Y, Sass S, Hesse M, Deussner-Helfmann NS, Dietz MS, Klevanski M, Kuner T, Heilemann M
bioRxiv, 22 Feb 2021
Cited by: 0 articles | PPR: PPR287124

Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy.
Asan L, Falfán-Melgoza C, Beretta CA, Sack M, Zheng L, Weber-Fahr W, Kuner T, Knabbe J
Sci Rep, 11(1):4234, 18 Feb 2021
Cited by: 9 articles | PMID: 33608622 | PMCID: PMC7895945

Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus.
Schäfer CB, Gao Z, De Zeeuw CI, Hoebeek FE
J Physiol, 599(7):2055-2073, 10 Feb 2021
Cited by: 2 articles | PMID: 33492688 | PMCID: PMC8048920

Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.
Egger V, Kuner T
Cell Tissue Res, 383(1):495-506, 05 Jan 2021
Cited by: 1 article | PMID: 33404844 | PMCID: PMC7873091

Synaptic input to brain tumors: clinical implications.
Venkataramani V, Tanev DI, Kuner T, Wick W, Winkler F
Neuro Oncol, 23(1):23-33, 31 Dec 2020
Cited by: 7 articles | PMID: 32623467 | PMCID: PMC7850064