Mastering the Patch Clamp Technique: A Practical Guide (English Edition)
Fabian Christoph Roth, Markus Numberger, Andreas Draguhn
The patch clamp technique is one of the most important electrophysiological methods in use today. Its application in basic biomedical research has provided significant insights into the function and properties of ion channels, making it equally indispensable in applied pharmacological research. This book is the English edition of the popular German introduction to the patch clamp technique. This introductory book serves as a practical guide for teachers and students, offering clear and practical instructions on patch clamp recordings. The authors provide essential information to establish and successfully apply this method in the laboratory. The book covers the basics of measurements, the detailed setup of a patch clamp rig and how to carry out typical recordings. It also includes concrete tips and tricks to help with troubleshooting, making it an indispensable resource. The book not only highlights the enormous potential of the method for the study of ion channels and cell signalling, but also provides an introduction to the major developments and variations of the technique.
The book is aimed at advanced students of biology, biochemistry, medicine, pharmacy and related disciplines as well as scientists who want to better understand and/or acquire the technique.
Opinion poll on animal welfare and the Animal Welfare Act in research and teaching at the Medical Faculty of Heidelberg University
Kristiana Becker1 and Thomas Korff2
1InterfacultyBiomedical Research Centre (IBF) of Heidelberg University, 2Instituteof Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University
Survey results on animal welfare and the Animal Welfare Act
The annotated results of the recent survey among project leaders of animal experiments at the University of Heidelberg on the subject of animal welfare and the Animal Welfare Act are available under the following link:
Opinion_survey_on_animal_welfare_and_animal_welfare_law_Medical_Faculty_of_Heidelberg.pdf
We would like to thank all participants of the survey once again for their co-operation!
Memory: rambles, reflections, images
ANDREAS DRAGUHN, HENRY KEAZOR, FRIEDERIKE REENTS (eds.)
What is memory? The book brings together the perspectives of scientists and artists who place themselves, society and the whole world in the context of their history.
Memory is a word used in everyday language, but also in many specialised languages. Psychology, brain research and psychiatry deal with memory, whose susceptibility to disruption challenges us today more than ever. But not only individuals, but also societies have a memory, they are the product of their history, which is always present and effective. The loss of collective memory also entails profound disruptions that threaten our localisation and anchoring in the world. And finally, animals and plants also have their individual and evolutionary history, even the earth and the universe. Do they also have a memory or do they embody it?
One thing is certain: there is no such thing as 'the' memory. The closer we look, the closer we come to a standardised definition that does justice to all aspects. This book attempts to provide answers by allowing different people with their respective perspectives to have their say, image and sound. Whether archaeologist or memory researcher, linguist or philosopher, astronomer or geographer, theologian or writer - each and every one of them has an individual perspective on what we call memory, characterised by their background, knowledge, social role and own experiences.
Brain Leitmotifs
The Structure and Activity Patterns of Neuronal Networks
Roger Traub and Andreas Draguhn
This book tackles the question of why the brain is so difficult to fully understand. In neuroscience, data are acquired and analysed with astonishing techniques and accumulate rapidly. Nevertheless, try to explain how a person can think or why there is such a condition as schizophrenia, and it appears that we really know little. To approach these difficulties, the authors first present a number of case studies in which the operation of a neural circuit is worked out in some detail and, at the same time, the functional significance of the operation is also understood. These examples are complicated in their biologic specifics but are conceptually straightforward. The examples are hoped to provoke an appreciation for what neuroscience can accomplish. The authors then develop some thoughts on how these issues can be addressed----instead of considering cognition in general, taking instead a subset of cognition that does lend itself to formal description.
Patch clamp technology
Fabian C. Roth, Markus Numberger, Andreas Draguhn
The patch-clamp technique is one of the most important neurophysiological working methods today. Its application in basic biomedical research has provided important insights into the function and properties of ion channels, and it has also become indispensable in applied pharmacological research. The authors provide the essential information for introducing and successfully applying the method in the laboratory in a clear and practical manner. The book explains the theoretical principles of the measurement, the detailed set-up of a measuring station and the practical implementation of typical measurement configurations. Concrete tips and tricks help with "trouble shooting" and are an indispensable aid not only for new users.
Paper of the Year 2023
German Physiological Society
Hodapp A, Kaiser ME, Thome C, Ding L, Rozov A, Klumpp M, Stevens N, Stingl M, Sackmann T, Lehmann N, Draguhn A, Burgalossi A, Engelhardt M, Both M. Dendritic axon origin enables information gatin by perisomatic inhibition in pyramidal neurons. Science. 2022 Sep 23;377(6613):1448-1452. doi: 10.1126/science.abj1861. Epub 2022 Sep 22.