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Integrating Microarray Data and Single-Cell RNA-Seq Reveals Key Gene Involved in Spermatogonia Stem Cell Aging
Hashemi Karoii D, Azizi H, Skutella T October 2024, International Journal of Molecular Sciences 25(21):11653 DOI: 10.3390/ijms252111653 

 

Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis.
Hashemi Karoii D, Baghaei H, Abroudi AS, Djamali M, Hasani Mahforoozmahalleh Z, Azizi H, Skutella T.Sci Rep. 2024 Oct 29;14(1):25965. doi: 10.1038/s41598-024-77875-

 

Axonal Regeneration after Spinal Cord Injury: Molecular Mechanisms, Regulatory Pathways, and Novel Strategies.
Elmalky MI, Alvarez-Bolado G, Younsi A, Skutella T.Biology (Basel). 2024 Sep 7;13(9):703. doi: 10.3390/biology 13090703 .

 

Translational evaluation of metabolic risk factors impacting DBS efficacy for PD-Related sleep and depressive disorders: preclinical, prospective and cohort studies.
Yao L, Chen R, Zheng Z, Hatami M, Koc S, Wang X, Bai Y, Yao C, Lu G, Skutella T.Int J Surg. 2024 Sep 6. doi: 10.1097/JS9.0000000000002081 . 

 

Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model.
Tail M, Zhang H, Zheng G, Harms AK, Hatami M, Skutella T, Kiening K, Unterberg A, Zweckberger K, Younsi A.J Inflamm (Lond). 2024 Sep 3;21(1):34. doi: 10.1186/s12950-024-00404-y .

 

Vaccine-based immunotherapy and related preclinical models for glioma: (Trends in Molecular Medicine, published online July 15, 2024).
Zhao B, Yao L, Hatami M, Ma W, Skutella T.Trends Mol Med. 2024 Sep 2:S1471-4914(24)00217-X. doi: 10.1016/j.molmed.2024.08.003 . 

 

Vaccine-based immunotherapy and related preclinical models for glioma.
Yao L, Hatami M, Ma W, Skutella T.Trends Mol Med. 2024 Oct;30(10):965-981. doi: 10.1016/j.molmed.2024.06.009 . 

 

Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis.
Karoii DH, Azizi H, Skutella T.BMC Genomics. 2024 Jun 11;25(1):583. doi: 10.1186/s12864-024-10506-9 

 

Microglia: a promising therapeutic target in spinal cord injury.
Zha X, Zheng G, Skutella T, Kiening K, Unterberg A, Younsi A.Neural Regen Res. 2025 Feb 1;20(2):454-463. doi: 10.4103/NRR.NRR-D-23-02044 ..

 

Unraveling the Significance of Nanog in the Generation of Embryonic Stem-like Cells from Spermatogonia Stem Cells: A Combined In Silico Analysis and In Vitro Experimental Approach.
Ghasemi N, Azizi H, Skutella T.Int J Mol Sci. 2024 Apr 29;25(9):4833. doi: 10.3390/ijms25094833 .

 

Clinical management, differential diagnosis, follow-up and biomarkers of infertile men with nonobstructive azoospermia.
Azizi H, Hashemi Karoii D, Skutella T.Transl Androl Urol. 2024 Feb 29;13(2):359-362. doi: 10.21037/tau-23-485 . Epub 2024 Feb 26.

 

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics.
Slivka JP, Bauer C, Younsi A, Wong MBF, Chan MKS, Skutella T.Int J Mol Sci. 2024 Mar 1;25(5):2863. doi: 10.3390/ijms25052863.

 

A review of the potential of induced pluripotent stem cell-derived exosome as a novel treatment for male infertility.
Sojoudi K, Azizi H, Skutella T.Biotechnol Genet Eng Rev. 2024 Oct;40(2):1353-1378. doi: 10.1080/02648725.2023.2193772 . 

 

A Study of Dual Function and Expression Pattern of Klf4 between Two Different Processes of Differentiation and Maintenance of Pluripotency in Spermatogonial Stem Cells. Andrologia.
Kiana Sojoudi, Hossein Azizi, Thomas Skutella. First published: 12 February 2024 

 

Exploring the toxicity and carcinogenic potential of 300 KDA “Mito Organelles”™ cellular extracts through MTT and BALB/C-3T3 cell transformation assays: a vital component of peptide and protein biomedical research and safety study.
Journal of Stem Cell Research & Therapeutics; 9(1):9-15. , 2024. Chan, Prof. Dr. MKS, Michelle B.F Wong, Dr. Dmytro Klokol, Dr. Olha Nishkumay, Halyna Mostbauer, Heike Dietrich and Thomas Skutella. DOI: 10.15406/jsrt.2024.09.00166 

 

New Technologies of Peptide Therapy in Bioregenerative Cardiology.
Journal of Cardiac Disorders and Therapy; 5(1): 1-12 2024. Yuriy Nalapko, Aljafri Abdul Majid, Jonathan RT Lakey, Thomas Skutella, Glen Alvin, Simon Yefimov, Svetlana Yartseva, Prof. Dr. Michelle B. F. Wong and Prof. Dr. Mike K. S. Chan

 

Stem Cell Therapies and Ageing: Unlocking the Potential of Regenerative Medicine. In: Biochemistry and Cell Biology of Ageing: Part V, Anti- Ageing Interventions.
Springer Nature and Robin, 2024. Chen Rui, Mike K. S. Chan and Thomas Skutella. 

 

Spermatogonial Stem Cells, Amazon Book 2024.
Azizi H. and Skutella T. ASIN ‏ : ‎B0CZDGQGV4, 167 pages SBN-13: ‎ 979-8321208724 

Impfstoffbasierte Immuntherapie und verwandte präklinische Modelle für Gliome: (Trends in Molecular Medicine, online veröffentlicht am 15. Juli 2024)
Binghao Zhao, Longping Yao, Maryam Hatami, Wenbin Ma, Thomas Skutella. Trends Mol Med. 2024 Sep 2:S1471-4914(24)00217-X. doi: 10.1016/j.molmed.2024.08.003. Online ahead of print.PMID: 39227193; Free article. 

Translational evaluation of metabolic risk factors impacting DBS efficacy for PD-Related sleep and depressive disorders: preclinical, prospective and cohort studies.
Yao L, Chen R, Zheng Z, Hatami M, Koc S, Wang X, Bai Y, Yao C, Lu G, Skutella T.Int J Surg. 2024 Sep 6. doi: 10.1097/JS9.0000000000002081. Online ahead of print.PMID: 39248306

LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease.
Yao L, Lu F, Koc S, Zheng Z, Wang B, Zhang S, Skutella T, Lu G.Adv Sci (Weinh). 2023 Sep 6:e2303711. doi: 10.1002/advs.202303711 . Online ahead of print.PMID: 37672887

Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.
Hashemi Karoii D, Azizi H, Skutella T.DNA Cell Biol. 2023 Aug 22. doi: 10.1089/dna.2023.0189 . Online ahead of print.PMID: 37610843

The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice.
Walter J, Mende J, Hutagalung S, Alhalabi OT, Grutza M, Zheng G, Skutella T, Unterberg A, Zweckberger K, Younsi A.Int J Mol Sci. 2023 Aug 14;24(16):12756. doi: 10.3390/ijms241612756 .PMID: 37628939

Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review.
Hamadelseed O, Chan MKS, Wong MBF, Skutella T.Front Neurosci. 2023 Aug 3;17:1225228. doi: 10.3389/fnins.2023.1225228 . eCollection 2023.PMID: 37600012

Correlating MRI-based brain volumetry and cognitive assessment in people with Down syndrome.
Hamadelseed O, Skutella T.Brain Behav. 2023 Jul 26:e3186. doi: 10.1002/brb3.3186 . Online ahead of print.PMID: 37496380

Sox2 Localization During Spermatogenesis and Its Association with other Spermatogenesis Markers Using Protein-Protein Network Analysis.
Reza E, Azizi H, Skutella T.J Reprod Infertil. 2023 Jul-Sep;24(3):171-180. doi: 10.18502/jri.v24i3.13273 .PMID: 37663428

Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model.
Zheng G, Harms AK, Tail M, Zhang H, Nimmo A, Skutella T, Kiening K, Unterberg A, Zweckberger K, Younsi A.Front Mol Neurosci. 2023 May 12;16:1128545. doi: 10.3389/fnmol.2023.1128545 . eCollection 2023.PMID: 37251648

Assessment of hindlimb motor recovery after severe thoracic spinal cord injury in rats: classification of CatWalk XT® gait analysis parameters.
Zheng G, Zhang H, Tail M, Wang H, Walter J, Skutella T, Unterberg A, Zweckberger K, Younsi A.Neural Regen Res. 2023 May;18(5):1084-1089. doi: 10.4103/1673-5374.355763 .PMID: 36254997 

Modulation of Cellular Senescence in HEK293 and HepG2 Cells by Ultrafiltrates UPla and ULu Is Partly Mediated by Modulation of Mitochondrial Homeostasis under Oxidative Stress.
Zhou J, Liu K, Bauer C, Bendner G, Dietrich H, Slivka JP, Wink M, Wong MBF, Chan MKS, Skutella T.Int J Mol Sci. 2023 Apr 4;24(7):6748. doi: 10.3390/ijms24076748 .PMID: 37047720

A Fundamental Research in In Vitro Spermatogonial Stem Cell Culturing: What Are Clump Cells?
Sojoudi K, Azizi H, Skutella T.Cell Reprogram. 2023 Apr;25(2):65-72. doi: 10.1089/cell.2022.0123 . Epub 2023 Feb 27.PMID: 36847738

A review of the potential of induced pluripotent stem cell-derived exosome as a novel treatment for male infertility.
Sojoudi K, Azizi H, Skutella T.Biotechnol Genet Eng Rev. 2023 Mar 23:1-26. doi: 10.1080/02648725.2023.2193772 . Online ahead of print.PMID: 36951621  Review.

Assessment of hindlimb motor recovery after severe thoracic spinal cord injury in rats: classification of CatWalk XT® gait analysis parameters.
Zheng G, Zhang H, Tail M, Wang H, Walter J, Skutella T, Unterberg A, Zweckberger K, Younsi A.Neural Regen Res. 2023 May;18(5):1084-1089. doi: 10.4103/1673-5374.355763.PMID: 36254997

Whole Exome Sequencing and In Silico Analysis of Human Sertoli in Patients with Non-Obstructive Azoospermia. Azizi H, Hashemi Karoii D, Skutella T. Int. J. Mol. Sci. 2022, 23, 12570. doi.org/10.3390/ijms232012570

VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.
Amirian M, Azizi H, Karoii DH, Skutella T.Sci Rep. 2022 Oct 14;12(1):17259. doi: 10.1038/s41598-022-22137-9.PMID: 36241908 Free PMC article.

Microarray and in silico analysis of DNA repair genes between human testis of patients with nonobstructive azoospermia and normal cells.
Karoii DH, Azizi H, Skutella T.Cell Biochem Funct. 2022 Sep 19. doi: 10.1002/cbf.3747. Online ahead of print.PMID: 36121211

Psychosocial Risk Factors for Alzheimer's Disease in Patients with Down Syndrome and Their Association with Brain Changes: A Narrative Review.
Hamadelseed O, Elkhidir IH, Skutella T.Neurol Ther. 2022 Sep;11(3):931-953. doi: 10.1007/s40120-022-00361-9. Epub 2022 May 21. PMID: 35596914 Free PMC article. Review.

Signaling Pathways and Protein-Protein Interaction of Vimentin in Invasive and Migration Cells: A Review.
Karoii DH, Azizi H, Amirian M.Cell Reprogram. 2022 Aug;24(4):165-174. doi: 10.1089/cell.2022.0025. Epub 2022 Jun 24. PMID: 35749708 Review.

The Role of Mitochondria in Cartilage Degenerative Disorders.
Yuriy N, Lakey JRT, Adalsteinsson O, Klokol D, Skutella T, Pan SY, Wellington A, Wong MBF, Chan MKS, Cox D. Int J Biomed Res Prac. 2022; 2(1); 1-6. 2022 Jul. ISSN 2769-6294. Review.

Novel options for chondrocyte restoration in osteoarthritis.
Nalapko Y, Klokol D, Lakey JRT, Adalsteinsson O, Pan SY, Skutella T, Wong MBF, Chan MKS. Stem Cells Regen Med. 2022 May; 6(1): 1-8. ISSN 2639-9512. Review.

The distribution of Dlx1-2 and glutamic acid decarboxylase in the embryonic and adult hypothalamus reveals three differentiated LHA subdivisions in rodents.
Barbier M, Croizier S, Alvarez-Bolado G, Risold PY.J Chem Neuroanat. 2022 Apr; 121:102089. doi: 10.1016/j.jchemneu.2022.102089. Epub 2022 Mar 10. PMID: 35283254 Review.

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2.
Küçükerden M, Schuster UE, Röckle I, Alvarez-Bolado G, Schwabe K, Hildebrandt H.Transl Psychiatry. 2022 Feb 3;12(1):51. doi: 10.1038/s41398-022-01816-1.PMID: 35115485 Free PMC article.

Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming.
Chen R, Skutella T.Cells. 2022 Feb 28;11(5):830. doi: 10.3390/cells11050830.PMID: 35269453 Free PMC article. Review.

The Sonic Hedgehog Pathway Modulates Survival, Proliferation, and Differentiation of Neural Progenitor Cells under Inflammatory Stress In Vitro.
Tail M, Zhang H, Zheng G, Hatami M, Skutella T, Unterberg A, Zweckberger K, Younsi A.Cells. 2022 Feb 20;11(4):736. doi: 10.3390/cells11040736.PMID: 35203385 Free PMC

New Insights in Spermatogonial Stem Cells.
Conrad S, Azizi H, Amirian M, Hatami M,  Skutella T. Chapter, First Online: 15 February 2022, Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL,volume 70). Springer.

Testicular Localization and Potential Function of Vimentin Positive Cells during Spermatogonial Differentiation Stages.
Niazi Tabar A, Azizi H, Karoii DH, Skutella T.Animals (Basel). 2022 Jan 22;12(3):268. doi: 10.3390/ani12030268.PMID: 35158592 Free PMC article.

Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G. TIP60/KAT5 is required for neuronal viability in hippocampal CA1. Sci Rep. 2019 Nov 7;9(1):16173. doi: 10.1038/s41598-019-50927-1.

Azizi H, Ranjbar M, Rahaiee S, Govahi M, Skutella T. Investigation of VASA Gene and Protein Expression in Neonate and Adult Testicular Germ Cells in Mice In Vivo and In Vitro. Cell J. 2020 Jul;22(2):171-177. doi: 10.22074/cellj.2020.6619. Epub 2019 Oct 14.

Azizi H, Koruji M, Skutella T. Comparison of PLZF Gene Expression between Pluripotent Stem Cells and Testicular Germ Cells. Cell J. 2020 Apr;22(1):60-65.
doi: 10.22074/cellj.2020.6532. Epub 2019 Sep 8. PubMed PMID: 31606967.

Conrad S, Younsi A, Bauer C, Geburek F, Skutella T Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-inflammatory Effects
In book: Stem Cell Transplantation for Autoimmune Diseases and Inflammation
August 2019, DOI: 10.1007/978-3-030-23421-8_6

Petkau N, Budak H, Zhou X, Oster H, Eichele G. Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Elife. 2019 Jul 11;8.
pii: e43235. doi: 10.7554/eLife.43235. PubMed PMID: 31294688; PubMed Central
PMCID: PMC6650244.

Azizi H, Asgari B, Skutella T. Pluripotency Potential of Embryonic Stem Cell-Like Cells Derived from Mouse Testis. Cell J. 2019 Oct;21(3):281-289. doi:
10.22074/cellj.2019.6068. Epub 2019 Jun 15. PubMed PMID: 31210434; PubMed Central
PMCID: PMC6582425.

Azizi H, Ghasemi Hamidabadi H, Skutella T. Differential Proliferation Effects after Short-Term Cultivation of Mouse Spermatogonial Stem Cells on Different
Feeder Layers. Cell J. 2019 Jul;21(2):186-193. doi: 10.22074/cellj.2019.5802.
Epub 2019 Feb 20. PubMed PMID: 30825292; PubMed Central PMCID: PMC6397599.

Alvarez-Bolado G. Development of neuroendocrine neurons in the mammalian hypothalamus. Cell Tissue Res. 2019 Jan;375(1):23-39. doi:
10.1007/s00441-018-2859-1. Epub 2018 Jun 5. Review. PubMed PMID: 29869716.

Babalian A, Eichenberger S, Bilella A, Girard F, Szabolcsi V, Roccaro D, Alvarez-Bolado G, Xu C, Celio MR. The orbitofrontal cortex projects to the
parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter. Brain Struct Funct. 2019
Jan;224(1):293-314. doi: 10.1007/s00429-018-1771-5. Epub 2018 Oct 12. PubMed
PMID: 30315416; PubMed Central PMCID: PMC6373537.

Hatami M, Conrad S, Naghsh P, Alvarez-Bolado G, Skutella T. Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons. Front Cell
Neurosci. 2018 Nov 12;12:402. doi: 10.3389/fncel.2018.00402. eCollection 2018.
Review. PubMed PMID: 30483057; PubMed Central PMCID: PMC6240695.

Conrad S, Weber K, Walliser U, Geburek F, Skutella T. Stem Cell Therapy for Tendon Regeneration: Current Status and Future Directions. Adv Exp Med Biol. 2018
Jul 25. doi: 10.1007/5584_2018_194. [Epub ahead of print] PubMed PMID: 30043235.

Virant-Klun I, Bauer C, Ståhlberg A, Kubista M, Skutella T. Human oocyte maturation in vitro is improved by co-culture with cumulus cells from mature
oocytes. Reprod Biomed Online. 2018 May;36(5):508-523. doi:
10.1016/j.rbmo.2018.01.011. Epub 2018 Feb 5. PubMed PMID: 29503212.

 Zhang Y, Hoxha E, Zhao T, Zhou X, Alvarez-Bolado G. Foxb1 Regulates Negatively the Proliferation of Oligodendrocyte Progenitors. Front Neuroanat. 2017 Jul
5;11:53. doi: 10.3389/fnana.2017.00053. eCollection 2017. PubMed PMID: 28725186;

Alvarez-Bolado G. Sonic hedgehog in Hypothalamus Development. In: Developmental Neuroendocrinology. S. Wray, S.Blackshaw (eds.). Masterclass in Neuroendocrinology 9. Springer Nature Switzerland AG 2020; ; doi.org/10.1007/978-3-030-40002-6_2