Neuroanatomie - Rui Chen

Tendon regeneration with stem cells

In adults, the healing tendon generates fibrovascular scar tissue and thus never histologically, mechanically and functionally recovers manifesting in chronic and degenerative diseases. The processes and mechanisms of tendon development, fetal regeneration in comparison to adult defect repair and degenerating are guiding generative therapeutic options. The application of stem cells, growth factors, transcription factors, and gene therapy in tendon injury therapies to intervene in the scarring process and to induce functional regeneration of the lesioned tissue is of major importance. We investigate future therapeutic approaches for tendon injuries involving molecular embryology, transgenic mouse models and stem cell technologies.