Institute Physiologie und… Neuro- und… Alexander Groh Publications



R.A. Mease, A. Groh, Corticothalamic Layer 5 Pathways and Synapses, Chapter 15 In: The Cerebral Cortex and Thalamus, W.M. Usrey and S.M. Sherman (eds.), Oxford University Press (2023)

K. Ziegler, R. Folkard, A.J. Gonzalez, J. Burghardt, S. Antharvedi-Goda, J. Martin-Cortecero, E. Isaías-Camacho, S. Kaushalya, L.L. Tan, T. Kuner, C. Acuna, R. Kuner, R.A. Mease, A. Groh, Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner, Nat. Commun. 14 (2023) 1–18.

J. Martín-Cortecero, E.U. Isaías-Camacho, B. Boztepe, K. Ziegler, R.A. Mease, A. Groh, Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals, PLoS Biol. 21 (2023) e3002126.


Z. Gan, V. Gangadharan, S. Liu, C. Körber, L.L. Tan, H. Li, M.J. Oswald, J. Kang, J. Martin-Cortecero, D. Männich, A. Groh, T. Kuner, S. Wieland, R, Kuner, Layer-specific pain relief pathways originating from primary motor cortex, Science. 378 (2022) 1336-1343. doi: 10.1126/science.add4391.

A. Groh, R. Mease, Corticothalamic Pathways in the Somatosensory System, in: The Thalamus, Cambridge University Press, 2022: pp. 221–236.

L. de Hoz, L. Busse, J.C. Hechavarria, A. Groh, M. Rothermel, SPP2411: ‘Sensing LOOPS: cortico-subcortical interactions for adaptive sensing,’ Neuroforum. 28 (2022) 249-251.


C.P.J. de Kock, J. Pie, A.W. Pieneman, R.A. Mease, A. Bast, J.M. Guest, M. Oberlaender, H.D. Mansvelder, B. Sakmann, High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch, Communications Biology. 4 (2021) 1–14.

R.A. Mease, A.J. Gonzalez, Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology, Front. Neural Circuits. 15 (2021) 88.

C. Castejon, J. Martin-Cortecero, A. Nuñez, Higher-Order Thalamic Encoding of Somatosensory Patterns and Bilateral Events, Front. Neural Circuits. 15 (2021) 120.

L.E. Maglio, J.A. Noriega-Prieto, I.B. Maroto, J. Martin-Cortecero, A. Muñoz-Callejas, M. Callejo-Móstoles, D. Fernández de Sevilla, IGF-1 facilitates extinction of conditioned fear, Elife. 10 (2021).


M. Wolff, S. Morceau, R. Folkard, J. Martin-Cortecero, A. Groh, A thalamic bridge from sensory perception to cognition, Neurosci. Biobehav. Rev. 120 (2020) 222–235.


I. Chaves-Coira, J. Martín-Cortecero, A. Nuñez, M.L. Rodrigo-Angulo, Basal Forebrain Nuclei Display Distinct Projecting Pathways and Functional Circuits to Sensory Primary and Prefrontal Cortices in the Rat, Front. Neuroanat. 12 (2018) 69.


A. Sumser, R.A. Mease, B. Sakmann, A. Groh, Organization and somatotopy of corticothalamic projections from L5B in mouse barrel cortex, Proc. Natl. Acad. Sci. U. S. A. 114 (2017) 8853–8858.

R.A. Mease, T. Kuner, A.L. Fairhall, A. Groh, Multiplexed Spike Coding and Adaptation in the Thalamus, Cell Rep. 19 (2017) 1130–1140.

A. Groh, R. Mease, P. Krieger, Wo der Schmerz in das Bewusstsein tritt: das thalamo-kortikale System bei der Schmerzverarbeitung, E-Neuroforum. 23 (2017) 567.

A. Groh, R. Mease, P. Krieger, Pain processing in the thalamocortical system, E-Neuroforum. 23 (2017) 64.

A. Groh, P. Krieger, R.A. Mease, L. Henderson, Acute and chronic pain processing in the thalamocortical system of humans and animal models, Neuroscience. (2017).


R.A. Mease, A. Sumser, B. Sakmann, A. Groh, Cortical Dependence of Whisker Responses in Posterior Medial Thalamus In Vivo, Cereb. Cortex. 26 (2016) 3534–3543.

R.A. Mease, A. Sumser, B. Sakmann, A. Groh, Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo, Cereb. Cortex. 26 (2016) 3461–3475.

R.A. Mease, M. Metz, A. Groh, Cortical Sensory Responses Are Enhanced by the Higher-Order Thalamus, Cell Rep. 14 (2016) 208–215.


A. Groh, P. Krieger, Introduction, in: P. Krieger, A. Groh (Eds.), Sensorimotor Integration in the Whisker System, Springer New York, New York, NY, 2015: pp. 1–4.

P. Krieger, A. Groh, Sensorimotor Integration in the Whisker System, 2015.


A. Groh, H. Bokor, R.A. Mease, V.M. Plattner, B. Hangya, A. Stroh, M. Deschenes, L. Acsády, Convergence of cortical and sensory driver inputs on single thalamocortical cells, Cereb. Cortex. 24 (2014) 3167–3179.

R.A. Mease, P. Krieger, A. Groh, Cortical control of adaptation and sensory relay mode in the thalamus, Proc. Natl. Acad. Sci. U. S. A. 111 (2014) 6798–6803.


A. Groh, P. Krieger, Structure-function analysis of genetically defined neuronal  populations, Cold Spring Harb. Protoc. 2013 (2013) 961–969.

A. Stroh, H. Adelsberger, A. Groh, C. Rühlmann, S. Fischer, A. Schierloh, K. Deisseroth, A. Konnerth, Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo, Neuron. 77 (2013) 1136–1150.


A. Groh, H.S. Meyer, E.F. Schmidt, N. Heintz, B. Sakmann, P. Krieger, Cell-type specific properties of pyramidal neurons in neocortex underlying a layout that is modifiable depending on the cortical area, Cereb. Cortex. 20 (2010) 826–836.


A. Groh, C.P.J. de Kock, V.C. Wimmer, B. Sakmann, T. Kuner, Driver or coincidence detector: modal switch of a corticothalamic giant synapse controlled by spontaneous activity and short-term depression, J. Neurosci. 28 (2008) 9652–9663.


V.C. Wimmer, H. Horstmann, A. Groh, T. Kuner, Cellular/Molecular Donut-Like Topology of Synaptic Vesicles with a Central Cluster of Mitochondria Wrapped into Membrane Protrusions: A Novel Structure–Function Module of the Adult Calyx of Held, Journal of Neuroscience. 26 (2006) 109–116.