Institute Institute for…

Institute for Computational Biomedicine

In the Institute for Computational Biomedicine we develop and apply computational methods to analyze complex biomedical data. Our goal is to acquire a functional understanding of molecular mechanisms in health and disease. We apply these insights to improve diagnosis and to develop novel therapeutics that we apply across diverse disease areas, including oncology, cardiology, nephrology, neurology, and infectious diseases.
We work closely with experimental and clinical groups within Heidelberg University’s Medical Faculty and University Hospital, as well as national and international collaborators. We are connected with the EMBL via the Molecular Medicine Partnership Unit on Chronic Kidney Disease (Saez-Rodriguez group), and we are also part of ELLIS, the European initiative for Artificial Intelligence, and diverse consortia including HiGHmed (Schapiro group) and SMART-Care (Lu and Saez-Rodriguez).
A key emphasis is to build models that are both mechanistic (to provide understanding) and predictive (to generate novel hypotheses), using methods from statistics, machine learning, and engineering. To build these models, we combine existing biological knowledge with large-scale molecular data, in particular genomics, transcriptomics and proteomics, obtained from patients or appropriate model systems.
We are dedicated to open science so all our computational tools are open-source which we share freely with the scientific community, and we support scientific crowdsourcing, specifically collaborative competitions, through the DREAM challenges.

There are three groups in the institute:
Saez-Rodriguez group -
Schapiro group  -
Lu group -

We are located on the 10th floor of the Marsilius Arkaden, Turm West, in the Im Neuenheimer Feld campus :
We always welcome enquiries to discuss synergies and collaborations.
Prof. Dr. Ing. Julio Saez-Rodriguez
Head of Saez-Rodriguez group and Director of Institute for Computational Biomedicine
Im Neuenheimer Feld 130.3, 10.307
69120 Heidelberg, Germany
E-Mail: pub.saez(at)
Tel: +49 6221  56 7521
Dr. sc. nat. Denis Schapiro
Head of Schapiro group, Institute for Computational Biomedicine and Institute of Pathology
Im Neuenheimer Feld 130.3, 10.304
69120 Heidelberg, Germany
E-Mail: Denis.Schapiro(at)
Dr. Junyan Lu
Head of Lu group, Institute for Computational Biomedicine and Center for Infectiology
Im Neuenheimer Feld 130.3, 10.318
69120 Heidelberg, Germany