Institute Physiologie und… Neuro- und… Claus Bruehl Publikationen


51: Semino F, Darche FF, Bruehl C, Koenen M, Skladny H, Katus HA, Frey N, Draguhn A, Schweizer PA. GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome. Pflugers Arch. 2023 Dec 1. doi: 10.1007/s00424-023-02882-0. Online ahead of print.


50: Boccuni I, Bas-Orth C, Bruehl C, Draguhn A, Fairless R. Glutamate transporter contribution to retinal ganglion cell vulnerability in a rat model of multiple sclerosis. Neurobiol Dis. 2023 Oct 15;187:106306. doi: 10.1016/j.nbd.2023.106306. Epub 2023 Sep 19.


49: Syren P, Rahm AK, Schweizer PA, Bruehl C, Katus HA, Frey N, Thomas D,Lugenbiel P. Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure. Life Sci. 2021 Sep 15;281:119769. doi: 10.1016/j.lfs.2021.119769. Epub 2021 Jun 26. PMID: 34186046.


48: Lugenbiel P, Govorov K, Syren P, Rahm AK, Wieder T, Wunsch M, Weiberg N, Manolova E, Gramlich D, Rivinius R, Finke D, Lehmann LH, Schweizer PA, Frank D, El Tahry FA, Bruehl C, Heimberger T, Sandke S, Weis T, Most P, Schmack B,Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x. PMID: 33630168.


47: Weigl I, Geschwill P, Reiss M, Bruehl C, Draguhn A, Koenen M, Sedaghat-Hamedani F, Meder B, Thomas D, Katus HA, Schweizer PA. The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31. PMID: 31481236.


46: Yampolsky P, Koenen M, Mosqueira M, Geschwill P, Nauck S, Witzenberger M, Seyler C, Fink T, Kruska M, Bruehl C, Schwoerer AP, Ehmke H, Fink RHA, DraguhnA, Thomas D, Katus HA, Schweizer PA. Augmentation of myocardial I<sub>f</sub> dysregulates calcium homeostasis and causes adverse cardiac remodeling. Nat Commun. 2019 Jul 23;10(1):3295. doi: 10.1038/s41467-019-11261-2. PMID: 31337768; PMCID: PMC6650438.


45: Darche FF, Rivinius R, Köllensperger E, Leimer U, Germann G, Seckinger A, Hose D, Schröter J, Bruehl C, Draguhn A, Gabriel R, Schmidt M, Koenen M, ThomasD, Katus HA, Schweizer PA. Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells. Life Sci. 2019 Sep 1;232:116620.

doi: 10.1016/j.lfs.2019.116620. Epub 2019 Jul 7. PMID: 31291594.

44: Mayer C, Bruehl C, Salt EL, Diem R, Draguhn A, Fairless R. Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. Neuroscience. 2018 Nov 21;393:258-272. doi:

10.1016/j.neuroscience.2018.07.040. Epub 2018 Aug 1. PMID: 30075244.


43: Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D,

Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, FreyN, Katus HA, Thomas D. TREK-1 (K2P2.1) channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control. Basic Res Cardiol. 2017 Jan;112(1):8.

doi: 10.1007/s00395-016-0597-7. Epub 2016 Dec 22. PMID: 28005193.


42: Schwale C, Schumacher S, Bruehl C, Titz S, Schlicksupp A, Kokocinska M,Kirsch J, Draguhn A, Kuhse J. KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons. Histochem Cell Biol. 2016

Jun;145(6):637-46. doi: 10.1007/s00418-015-1397-0. Epub 2016 Jan 16. PMID:



41: Möller K, Adolph O, Grünow J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C,

Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH,Hecker M. Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells. Thromb Haemost. 2015 May;113(5):1095-108.

doi: 10.1160/TH14-04-0336. Epub 2015 Jan 22. PMID: 25608503.


40: Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, BussSJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol. 2014 Aug

26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155. PMID: 25145518.


39: Fiore R, Rajman M, Schwale C, Bicker S, Antoniou A, Bruehl C, Draguhn A,Schratt G. MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression. EMBO J. 2014 Oct 1;33(19):2231-46. doi:

10.15252/embj.201487921. Epub 2014 Aug 5. PMID: 25097251; PMCID: PMC4282509.


38: Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, Bruehl C,Nimmrich V. Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers. Eur J Pharmacol. 2013 Feb 28;702(1-3):44-55. doi:

10.1016/j.ejphar.2013.01.030. Epub 2013 Jan 30. PMID: 23376566.


37: Hermann D, Mezler M, Swensen AM, Bruehl C, Obergrußerger A, Wicke K,Schoemaker H, Gross G, Draguhn A, Nimmrich V. Establishment of a secondary screening assay for P/Q-type calcium channel blockers. Comb Chem High Throughput

Screen. 2013 Mar;16(3):233-43. doi: 10.2174/1386207311316030008. PMID: 23228050.


36: Duhme N, Schweizer PA, Thomas D, Becker R, Schröter J, Barends TR,Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J. 2013 Sep;34(35):2768-75. doi:

10.1093/eurheartj/ehs391. Epub 2012 Nov 23. PMID: 23178648.


35: Sinning A, Liebmann L, Kougioumtzes A, Westermann M, Bruehl C, Hübner CA.Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8. J Neurosci. 2011 May 18;31(20):7300-11. doi:

10.1523/JNEUROSCI.0269-11.2011. PMID: 21593314; PMCID: PMC6622604.

34: Schmidt S, Bruehl C, Frahm C, Redecker C, Witte OW. Age dependence of excitatory-inhibitory balance following stroke. Neurobiol Aging. 2012

Jul;33(7):1356-63. doi: 10.1016/j.neurobiolaging.2010.11.019. Epub 2011 Jan 22.

PMID: 21257232.

33: Holter NI, Zylla MM, Zuber N, Bruehl C, Draguhn A. Tonic GABAergic control of mouse dentate granule cells during postnatal development. Eur J Neurosci.

2010 Oct;32(8):1300-9. doi: 10.1111/j.1460-9568.2010.07331.x. Epub 2010 Sep 16.

PMID: 20846322.


32: Schweizer PA, Duhme N, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C,Katus HA, Koenen M. cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control. Circ Arrhythm

Electrophysiol. 2010 Oct;3(5):542-52. doi: 10.1161/CIRCEP.110.949768. Epub 2010

Aug 7. PMID: 20693575.

31: Bertsche A, Bruehl C, Pietz J, Draguhn A. Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices. Epilepsy Res. 2010 Feb;88(2-3):118-26. doi:

19.1016/j.eplepsyres.2009.10.006. Epub 2009 Nov 24. PMID: 19939631.

30: Hartmann K, Bruehl C, Golovko T, Draguhn A. Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling. PLoS One. 2008 Aug

20;3(8):e2979. doi: 10.1371/journal.pone.0002979. PMID: 18714334; PMCID:


29: Grimm C, Holter NI, Draguhn A, Bruehl C. Compensatory increase in P/Q-calcium current-mediated synaptic transmission following chronic block of N-type channels. Neurosci Lett. 2008 Sep 5;442(1):44-9. doi:

10.1016/j.neulet.2008.06.066. Epub 2008 Jun 27. PMID: 18602451.

28: Schmidt S, Redecker C, Bruehl C, Witte OW. Age-related decline of functional inhibition in rat cortex. Neurobiol Aging. 2010 Mar;31(3):504-11. doi:

10.1016/j.neurobiolaging.2008.04.006. Epub 2008 May 19. PMID: 18486993.


27: Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, HillenH, Gross G, Ebert U, Bruehl C. Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci. 2008 Jan 23;28(4):788-97. doi:

10.1523/JNEUROSCI.4771-07.2008. PMID: 18216187; PMCID: PMC6671006.

26: Holter NI, Zuber N, Bruehl C, Draguhn A. Functional maturation of developing interneurons in the molecular layer of mouse dentate gyrus. Brain Res. 2007

Dec;1186:56-64. doi: 10.1016/j.brainres.2007.09.089. Epub 2007 Oct 12. PMID:


25: Urbach A, Bruehl C, Witte OW. Microarray-based long-term detection of genes differentially expressed after cortical spreading depression. Eur J Neurosci.

2006 Aug;24(3):841-56. doi: 10.1111/j.1460-9568.2006.04862.x. PMID: 16930413.

24: Schmidt S, Bruehl C, Hagemann G, Witte OW, Redecker C. Impairment of functional inhibition in the contralateral cortex following perinatally acquired malformations in rats. Exp Neurol. 2006 Sep;201(1):270-4. doi:

10.1016/j.expneurol.2006.03.027. Epub 2006 Jun 5. PMID: 16750529.

23: Frahm C, Haupt C, Weinandy F, Siegel G, Bruehl C, Witte OW. Regulation of GABA transporter mRNA and protein after photothrombotic infarct in rat brain. J

Comp Neurol. 2004 Oct 11;478(2):176-88. doi: 10.1002/cne.20282. PMID: 15349978.

22: Peters O, Redecker C, Hagemann G, Bruehl C, Luhmann HJ, Witte OW. Impaired synaptic plasticity in the surround of perinatally acquired [correction of aquired] dysplasia in rat cerebral cortex. Cereb Cortex. 2004 Oct;14(10):1081-7.

doi: 10.1093/cercor/bhh067. Epub 2004 Apr 27. PMID: 15115746.

21: Diehm SM, Witte OW, Bruehl C. Differential alterations of the inactivation properties of high voltage activated calcium currents in area CA1 and CA3 of the rat following photothrombotic lesion. Neurosci Lett. 2003 May 1;341(2):147-50.

doi: 10.1016/s0304-3940(03)00192-7. PMID: 12686387.

20: Bruehl C, Witte OW. Relation between bicarbonate concentration and voltage dependence of sodium currents in freshly isolated CA1 neurons of the rat. J

Neurophysiol. 2003 May;89(5):2489-98. doi: 10.1152/jn.01083.2002. Epub 2002 Dec

27. PMID: 12611966.

19: Kraemer M, Roth-Haerer A, Bruehl C, Luhmann HJ, Witte OW. Metabolic and electrophysiological alterations in an animal model of neocortical neuronal migration disorder. Neuroreport. 2001 Jul 3;12(9):2001-6. doi:

10.1097/00001756-200107030-00044. PMID: 11435937.

18: Bruehl C, Neumann-Haefelin T, Witte OW. Enhancement of whole cell calcium currents following transient MCAO. Brain Res. 2000 Nov 24;884(1--2):129-38. doi:

10.1016/s0006-8993(00)02927-9. PMID: 11082494.

17: Bruehl C, Wadman WJ, Witte OW. Concentration dependence of bicarbonate- induced calcium current modulation. J Neurophysiol. 2000 Nov;84(5):2277-83. doi:

10.1152/jn.2000.84.5.2277. PMID: 11067971.

16: Witte OW, Bruehl C. Distant functional and metabolic disturbances in focal epilepsy. Adv Neurol. 1999;81:383-8. PMID: 10609037.


15: Reinecke S, Lutzenburg M, Hagemann G, Bruehl C, Neumann-Haefelin T, WitteOW. Electrophysiological transcortical diaschisis after middle cerebral artery occlusion (MCAO) in rats. Neurosci Lett. 1999 Feb 12;261(1-2):85-8. doi:

10.1016/s0304-3940(99)00014-2. PMID: 10081933.

14: Schiene K, Staiger JF, Bruehl C, Witte OW. Enlargement of cortical vibrissa representation in the surround of an ischemic cortical lesion. J Neurol Sci.

1999 Jan 1;162(1):6-13. doi: 10.1016/s0022-510x(98)00292-5. PMID: 10064162.

13: Hagemann G, Hoeller M, Bruehl C, Lutzenburg M, Witte OW. Effects of tetanus toxin on functional inhibition after injection in separate cortical areas in rat. Brain Res. 1999 Feb 6;818(1):127-34. doi: 10.1016/s0006-8993(98)01293-1.

PMID: 9914445.

12: Bruehl C, Wadman WJ. Calcium currents in acutely isolated stellate and pyramidal neurons of rat entorhinal cortex. Brain Res. 1999 Jan

23;816(2):554-62. doi: 10.1016/s0006-8993(98)01234-7. PMID: 9878880.

11: Bruehl C, Hagemann G, Witte OW. Uncoupling of blood flow and metabolism in focal epilepsy. Epilepsia. 1998 Dec;39(12):1235-42. doi:

10.1111/j.1528-1157.1998.tb01320.x. PMID: 9860057.

10: Bruehl C, Wagner U, Huston JP, Witte OW. Thalamocortical circuits causing remote hypometabolism during focal interictal epilepsy. Epilepsy Res. 1998

Nov;32(3):379-87. doi: 10.1016/s0920-1211(98)00066-7. PMID: 9839778.

9: Hagemann G, Bruehl C, Lutzenburg M, Witte OW. Brain hypometabolism in a model of chronic focal epilepsy in rat neocortex. Epilepsia. 1998

Apr;39(4):339-46. doi: 10.1111/j.1528-1157.1998.tb01385.x. PMID: 9578023.

8: Gass P, Bruehl C, Herdegen T, Kiessling M, Lutzenburg M, Witte OW. Induction of FOS and JUN proteins during focal epilepsy: congruences with and differences to [14C]deoxyglucose metabolism. Brain Res Mol Brain Res. 1997

Jun;46(1-2):177-84. doi: 10.1016/s0169-328x(96)00300-2. PMID: 9191092.

7: Redecker C, Bruehl C, Hagemann G, Binus O, Witte OW. Coupling of cortical and thalamic metabolism in experimentally induced visual and somatosensory focal epilepsy. Epilepsy Res. 1997 May;27(2):127-37. doi:

10.1016/s0920-1211(97)01029-2. PMID: 9192187.


6: Vreugdenhil M, Bruehl C, Voskuyl RA, Kang JX, Leaf A, Wadman WJ.

Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.

Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12559-63. doi:

10.1073/pnas.93.22.12559. PMID: 8901621; PMCID: PMC38031.


5: Schiene K, Bruehl C, Zilles K, Qü M, Hagemann G, Kraemer M, Witte OW.Neuronal hyperexcitability and reduction of GABAA-receptor expression in the surround of cerebral photothrombosis. J Cereb Blood Flow Metab. 1996

Sep;16(5):906-14. doi: 10.1097/00004647-199609000-00014. PMID: 8784234.

4: Witte OW, Bruehl C, Hossmann KA. Metabolic and electrophysiological effects of focal epileptic discharges on surrounding and remote brain tissue in the rat cortex. Epilepsy Res Suppl. 1996;12:157-62. PMID: 9302514.

3: Bruehl C, Witte OW. Cellular activity underlying altered brain metabolism during focal epileptic activity. Ann Neurol. 1995 Sep;38(3):414-20. doi:

10.1002/ana.410380311. PMID: 7668827.

2: Bruehl C, Kloiber O, Hossman KA, Dorn T, Witte OW. Regional hypometabolism in an acute model of focal epileptic activity in the rat. Eur J Neurosci. 1995

Feb 1;7(2):192-7. doi: 10.1111/j.1460-9568.1995.tb01055.x. PMID: 7757256.


1: Witte OW, Bruehl C, Schlaug G, Tuxhorn I, Lahl R, Villagran R, Seitz RJ.

Dynamic changes of focal hypometabolism in relation to epileptic activity. J

Neurol Sci. 1994 Jul;124(2):188-97. doi: 10.1016/0022-510x(94)90325-5. Erratum

in: J Neurol Sci 1994 Oct;126(1):95. PMID: 7964870.