Publikationen

_51.

_{Khamehgir-Silz P, Schnitter F, Wagner AH, Gerbig S, Schulz S, Hecker M, Spengler B. Strategy for marker-based differentiation of pro- and anti-inflammatory macrophages using matrix-assisted laser desorption/ionization mass spectrometry imaging. Analyst. 2018 Sep 10;143(18):4273-4282. doi: 10.1039/c8an00659h. Epub 2018 Jul 20.}

_50.

_{Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH. Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1.}

_49.

_{Popa M, Tahir S, Elrod J, Kim SH, Leuschner F, Kessler T, Bugert P, Pohl U, Wagner AH, Hecker M. Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5556-E5565. doi: 10.1073/pnas.1801366115. Epub 2018 May 23.}

_48.

_{Kuk H, Arnold C, Wagner AH, Hecker M, Sticht C, Korff T. Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice. Front Physiol. 2018 Apr 4;9:320. doi: 10.3389/fphys.2018.00320. eCollection 2018.}

_47.

_{Weigand T, Singler B, Fleming T, Nawroth P, Klika KD, Thiel C, Baelde H, Garbade SF, Wagner AH, Hecker M, Yard BA, Amberger A, Zschocke J, Schmitt CP, Peters V. Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal. Cell Physiol Biochem. 2018;46(2):713-726. doi: 10.1159/000488727. Epub 2018 Mar 29.}

_46.

_{Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M. Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.}

_45.

_{Hecker M, Wagner AH. Role of protein carbonylation in diabetes. J Inherit Metab Dis. 2018 Jan;41(1):29-38. doi: 10.1007/s10545-017-0104-9. Epub 2017 Nov 6}

_44.

_{Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K. AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome. Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.}

_43.

_{Peters V, Schmitt CP, Weigand T, Klingbeil K, Thiel C, van den Berg A, Calabrese V, Nawroth P, Fleming T, Forsberg E, Wagner AH, Hecker M, Vistoli G. Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1102-1110. doi: 10.1080/14756366.2017.1355793.}

_42.

_{Eschrich J, Meyer R, Kuk H, Wagner AH, Noppeney T, Debus S, Hecker M, Korff T. Varicose Remodeling of Veins Is Suppressed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors. J Am Heart Assoc. 2016 Feb 23;5(2). pii: e002405. doi: 10.1161/JAHA.115.002405.}

_41.

_{Seppelt PC, Schwill S, Weymann A, Arif R, Weber A, Zaradzki M, Richter K, Ensminger S, Robinson PN, Wagner AH, Karck M, Kallenbach K. Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy. PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.}

_40.

_{Peters V, Lanthaler B, Amberger A, Fleming T, Forsberg E, Hecker M, Wagner AH, Yue WW, Hoffmann GF, Nawroth P, Zschocke J, Schmitt CP. Carnosine metabolism in diabetes is altered by reactive metabolites. Amino Acids. 2015 Nov;47(11):2367-2376. Epub 2015 Jun 17.} 

_39.

_{Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M. Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells. J Am Heart Assoc. 2015 Jun 12;4(6). pii: e001712.}

_38.

_{Wagner AH, Conzelmann M, Fitzer F, Giese T, Gülow K, Falk CS, Krämer OH, Dietrich S, Hecker M, Luft T. JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter. Biochem Pharmacol. 2015 Jul 1;96(1):52-64. doi: 10.1016/j.bcp.2015.04.019. Epub 2015 Apr 28.}

_37.

_{Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-Valdes N, Umansky V, Schneider SW. von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood. 2015 May 14;125(20):3153-63. doi: 10.1182/blood-2014-08-595686. Epub 2015 Feb 24.}

_36.

_{Möller K, Adolph O, Grünow J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C, Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH, Hecker M. Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells. 2015 May;113(5):1095-108. doi: 10.1160/TH14-04-0336. Epub 2015 Jan 22.}

_35.

_{Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T. TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells. Front Physiol. 2014 Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014.}

_34.

_{Wagner AH, Schwarz M, König G, Hecker M. Role of platelet CD40 ligand for endothelial cell-monocyte interaction in the presence of flow. Korea-Aust Rheol J. 2014 Nov;26(4):405-8.}

_33.

_{Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T. Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells. J Am Heart Assoc. 2014 Mar 10;3(2):e000626. doi: 10.1161/​JAHA.113.000626.}

_32.

_{Dietrich S, Okun JG, Schmidt K, Falk CS, Wagner AH, Karamustafa S, Radujkovic A, Hegenbart U, Ho AD, Dreger P, Luft T. High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statins. Haematologica. 2014 Mar;99(3):541-7. doi: 10.3324/haematol.2013.090209. Epub 2013 Oct 18.}

_31.

_{Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M. Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells. Blood. 2011 Sep 29;118(13):3734-42. Epub 2011 Aug 10.}

_30.

_{Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H. Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. Basic Res Cardiol. 2011 Jun;106(4):551-61. Epub 2011 Mar 12.}

_29.

_{Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T. IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. Epub 2010 Aug 13.}

_28.

_{Lührmann A, Tschernig T, von der Leyen H, Hecker M, Pabst R, Wagner AH. Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. Exp Lung Res. 2010 Mar;36(2):85-93.}

_27.

_{Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Güldenzoph B, Bermejo JL, Korff T, Hecker M. Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1894-901. Epub 2009 Sep 3.}

_26.

_{Stojanovic T, Wagner AH, Wang S, Kiss E, Rockstroh N, Bedke J, Gröne HJ, Hecker M. STAT-1 decoy oligodeoxynucleotide inhibition of acute rejection in mouse heart transplants. Basic Res Cardiol. 2009 Nov;104(6):719-29. Epub 2009 Apr 8.}

_25.

_{Morawietz H, Wagner AH, Hecker M, Goettsch W. Endothelin receptor B-mediated induction of c-jun and AP-1 in response to shear stress in human endothelial cells. Can J Physiol Pharmacol. 2008 Aug;86(8):499-504.}

_24.

_{Stadlbauer TH, Wagner AH, Hölschermann H, Fiedel S, Fingerhuth H, Tillmanns H, Bohle RM, Hecker M. AP-1 and STAT-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts. Cardiovasc Res. 2008 Sep 1;79(4):698-705. Epub 2008 May 29.}

_23.

_{Wagner AH, Wittjen I, Stojanovic T, Middel P, Meingassner JG, Hecker M. Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity. J Allergy Clin Immunol. 2008 Jan;121(1):158-165.e5. Epub 2007 Nov 5.}

_22.

_{Stojakovic M, Krzesz R, Wagner AH, Hecker M. CD154-stimulated GM-CSF release by vascular smooth muscle cells elicits monocyte activation--role in atherogenesis. J Mol Med. 2007 Nov;85(11):1229-38. Epub 2007 Jul 10.}

_21.

_{Stojanovic T, Scheele L, Wagner AH, Middel P, Bedke J, Lautenschläger I, Leister I, Panzner S, Hecker M. STAT-1 decoy oligonucleotide improves microcirculation and reduces acute rejection in allogeneic rat small bowel transplants. Gene Ther. 2007 Jun;14(11):883-90. Epub 2007 Mar 15.}

_20.

_{Kusch B, Waldhans S, Sattler A, Wagner A, Hecker M, Moosdorf R, Vogt S. Inhibition of carotis venous bypass graft disease by intraoperative nucleic acid-based therapy in rabbits. Thorac Cardiovasc Surg. 2006 Sep;54(6):388-92.}

_19.

_{Hölschermann H, Stadlbauer TH, Wagner AH, Fingerhuth H, Muth H, Rong S, Güler F, Tillmanns H, Hecker M. STAT-1 and AP-1 decoy oligonucleotide therapy delays acute rejection and prolongs cardiac allograft survival. Cardiovasc Res. 2006 Aug 1;71(3):527-36. Epub 2006 May 27.}

_18.

_{Hückel M, Schurigt U, Wagner AH, Stöckigt R, Petrow PK, Thoss K, Gajda M, Henzgen S, Hecker M, Bräuer R. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther. 2006;8(1):R17.}

_17.

_{Gao D, Wagner AH, Fankhaenel S, Stojanovic T, Schweyer S, Panzner S, Hecker M. CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut. 2005 Jan;54(1):70-7.}

_16.

_{Quarcoo D, Weixler S, Groneberg D, Joachim R, Ahrens B, Wagner AH, Hecker M, Hamelmann E. Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity. J Allergy Clin Immunol. 2004 Aug;114(2):288-95.}

_15.

_{Wagner AH, Güldenzoph B, Lienenlüke B, Hecker M. CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):715-20. Epub 2004 Feb 19.}

_14.

_{Schweyer S, Soruri A, Peters J, Wagner A, Radzun HJ, Fayyazi A. Malignant germ cell tumours of the testis express interferon-gamma, but are resistant to endogenous interferon-gamma. Br J Cancer. 2003 Sep 1;89(5):915-21.}

_13.

_{Schaeffer G, Levak-Frank S, Spitaler MM, Fleischhacker E, Esenabhalu VE, Wagner AH, Hecker M, Graier WF. Intercellular signalling within vascular cells under high D-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia. 2003 Jun;46(6):773-83. Epub 2003 Jun 13.}

_12.

_{Wagner AH, Gebauer M, Güldenzoph B, Hecker M. 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1784-9.}

_11.

_{Tiran A, Gruber HJ, Graier WF, Wagner AH, Van Leeuwen EB, Tiran B. Aspirin inhibits Chlamydia pneumoniae-induced nuclear factor-kappa B activation, cytokine expression, and bacterial development in human endothelial cells. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1075-80.}

_10.

_{Kelkenberg U, Wagner AH, Sarhaddar J, Hecker M, von der Leyen HE. CCAAT/enhancer-binding protein decoy oligodeoxynucleotide inhibition of macrophage-rich vascular lesion formation in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):949-54.}

_9.

_{Wagner AH, Schwabe O, Hecker M. Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. Br J Pharmacol. 2002 May;136(1):143-9.}

_8.

_{Buchwald AB, Wagner AH, Webel C, Hecker M. Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs. J Am Coll Cardiol. 2002 Feb 20;39(4):732-8.}

_7.

_{Wagner AH, Gebauer M, Pollok-Kopp B, Hecker M. Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1. Blood. 2002 Jan 15;99(2):520-5.}

_6.

_{Wagner AH, Schroeter MR, Hecker M. 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 2001 Oct;15(12):2121-30.}

_5.

_{Lauth M, Wagner AH, Cattaruzza M, Orzechowski HD, Paul M, Hecker M. Transcriptional control of deformation-induced preproendothelin-1 gene expression in endothelial cells. J Mol Med. 2000;78(8):441-50.}

_4.

_{Wagner AH, Krzesz R, Gao D, Schroeder C, Cattaruzza M, Hecker M. Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells. Mol Pharmacol. 2000 Dec;58(6):1333-40.}

_3.

_{Cattaruzza M, Wachter R, Wagner AH, Hecker M. Modulation by dihydropyridine-type calcium channel antagonists of cytokine-inducible gene expression in vascular smooth muscle cells. Br J Pharmacol. 2000 Mar;129(6):1155-62.}

_2.

_{Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.}

_1.

_{Krzesz R, Wagner AH, Cattaruzza M, Hecker M. Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappaB and signal transducer and activation of transcription-1. FEBS Lett. 1999 Jun 18;453(1-2):191-6.}