Institute Institute Physiologie und… Herz- und… Nina D. Ullrich Publikationen

Publikationen

34. Carl-Mattheis Wahl, Constanze Schmidt, Markus Hecker, Nina D. Ullrich. Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases. Int. J. Mol. Sci. 2022, Sep 5;23 (17):10174. doi: 10.3390/ijms23171074.
33. Fabrice F. Darche, Nina D. Ullrich, Ziqiang Huang, Michael Koenen, Rasmus Rivinius, Norbert Frey, Patrick A. Schweizer. Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols​​​​​​​. Int. J. Mol. Sci. 2022, 23, 7318. doi: 10.3390/ijms23137318. 
32.

Körner A, Mosqueira M, Hecker M, Ullrich ND. Substrate Stiffness Influences Structural and Functional Remodeling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Front Physiol. 2021 Aug 19;12:1306. doi: 10.3389/fphys.2021.710619

31.

Remes A, Wagner AH, Schmiedel N, Heckmann M, Ruf T, Ding L, Jungmann A, Senger F, Katus HA, Ullrich ND, Frey N, Hecker M, Müller OJ. AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure. Basic Res Cardiol. 2021 Jun 4;116(1):38. doi: 10.1007/s00395-021-00880-w.

30.

Rahm AK, Gramlich D, Wieder T, Müller ME, Schoeffel A, El Tahry FA, Most P, Heimberger T, Sandke S, Weis T, Ullrich ND, Korff T, Lugenbiel P, Katus HA, Thomas D. Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation. Pharmgenomics Pers Med. 2021 May 20;14:579-590. doi: 10.2147/PGPM.S290291. eCollection 2021.

29.

Rahm AK, Müller ME, Gramlich D, Lugenbiel P, Uludag E, Rivinius R, Ullrich ND, Schmack B, Ruhparwar A, Heimberger T, Weis T, Karck M, Katus HA, Thomas D. Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Aug 5;880:173159. doi: 10.1016/j.ejphar.2020.173159. Epub 2020 Apr 29.

28.

Silbernagel N, Körner A, Balitzki J, Jaggy M, Bertels S, Richter B, Hippler M, Hellwig A, Hecker M, Bastmeyer M, Ullrich ND. Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.

27.

Schmitt K, Molfenter B, Laureano NK, Tawk B, Bieg M, Hostench XP, Weichenhan D, Ullrich ND, Shang V, Richter D, Stögbauer F, Schroeder L, de Bem Prunes B, Visioli F, Rados PV, Jou A, Plath M, Federspil PA, Thierauf J, Döscher J, Weissinger SE, Hoffmann TK, Wagner S, Wittekindt C, Ishaque N, Eils R, Klussmann JP, Holzinger D, Plass C, Abdollahi A, Freier K, Weichert W, Zaoui K, Hess J. Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer. Int J Cancer. 2019 Dec 15;145(12):3299-3310. doi: 10.1002/ijc.32481. Epub 2019 Jun 19.

26.

Jiang F, Mohr F, Ullrich ND, Hecker M, Wagner AH. Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019 Oct 15;383(2):111565. doi: 10.1016/j.yexcr.2019.111565. Epub 2019 Aug 20.

25.

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Nov;32(11):6159-6173. Epub 2018 Jun 7.

24.

Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND. Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol. 2018 Jul;120:31-41. doi: 10.1016/j.yjmcc.2018.05.010. Epub 2018 May 16.

23.

Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D. Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

22.

Srimachai S, Devaux S, Demougeot C, Kumphune S, Ullrich ND, Niggli E, Ingkaninan K, Kamkaew N, Scholfield CN, Tapechum S, Chootip K. Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complement Altern Med. 2017 Feb 20;17(1):117. doi: 10.1186/s12906-017-1637-z.

21.

Sekulic-Jablanovic M, Ullrich ND, Goldblum D, Palmowski-Wolfe A, Zorzato F, Treves S. Functional characterization of orbicularis oculi and extraocular muscles. J Gen Physiol. 2016 May;147(5):395-406. doi: 10.1085/jgp.201511542. Epub 2016 Apr 11.

20.

Kucera JP, Prudat Y, Marcu IC, Azzarito M, Ullrich ND. Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Front Cell Dev Biol. 2015 Sep 24;3:58. eCollection 2015.

19.

Beauchamp P, Moritz W, Kelm JM, Ullrich ND, Agarkova I, Anson B, Suter TM, Zuppinger C. Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes.Tissue Eng Part C Methods. 2015 Aug;21(8):852-61. doi: 10.1089/ten.TEC.2014.0376. Epub 2015 Mar 16.

18.

Marcu IC, Illaste A, Heuking P, Jaconi ME, Ullrich ND. Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes. Stem Cells. 2015 Jul;33(7):2208-2218. doi: 10.1002/stem.2009. Epub 2015 May 12.

17.

Dias P, Desplantez T, El-Harasis MA, Chowdhury RA, Ullrich ND, Cabestrero de Diego A, Peters NS, Severs NJ, MacLeod KT, Dupont E. Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line. PLoS One. 2014 Feb 28;9(2):e90266. doi: 10.1371/journal.pone.0090266. eCollection 2014.

16.

Brinks H, Giraud MN, Segiser A, Ferrié C, Longnus S, Ullrich ND, Koch WJ, Most P, Carrel TP, Tevaearai HT. Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. J Heart Lung Transplant. 2014 Feb;33(2):203-10. doi: 10.1016/j.healun.2013.10.006. Epub 2013 Oct 4.

15.

Rokach O, Ullrich ND, Rausch M, Mouly V, Zhou H, Muntoni F, Zorzato F, Treves S. Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization. Biochem J. 2013 Oct 15;455(2):169-77. doi: 10.1042/BJ20130698.

14.

Horn T, Ullrich ND, Egger M. 'Eventless' InsP3-dependent SR-Ca2+ release affecting atrial Ca2+ sparks. J Physiol. 2013 Apr 15;591(Pt 8):2103-11. doi: 10.1113/jphysiol.2012.247288. Epub 2013 Feb 4.

13.

Niggli E, Ullrich ND, Gutierrez D, Kyrychenko S, Poláková E, Shirokova N. Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta. 2013 Apr;1833(4):866-75. doi: 10.1016/j.bbamcr.2012.08.016. Epub 2012 Aug 31. Review.

12.

Kyrychenko S, Poláková E, Kang C, Pocsai K, Ullrich ND, Niggli E, Shirokova N. Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc Res. 2013 Mar 15;97(4):666-75. doi: 10.1093/cvr/cvs425. Epub 2012 Dec 21.

11.

Guex GA, Romano F, Marcu IC, Tevaearai HS, Ullrich ND, Giraud MN. Culture of cardiogenic stem cells on PCL-scaffolds: towards the creation of beating tissue constructs. In: Proceedings of the 10th IASTED International Conference on Biomedical Engineering (791) Biomedical Engineering 2013. Boccaccini AR (Ed.) ACTA Press, Calgary, Canada 2013; DOI: 10.2316/P.2013.791-080.

10.

Ullrich ND, Valdivia HH, Niggli E. PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J Mol Cell Cardiol. 2012 Jul;53(1):33-42. doi: 10.1016/j.yjmcc.2012.03.015. Epub 2012 Apr 1.

9.

Gonzales C, Ullrich ND, Gerber S, Berthonneche C, Niggli E, Pedrazzini T. Isolation of cardiovascular precursor cells from the human fetal heart. Tissue Eng Part A. 2012 Jan;18(1-2):198-207. doi: 10.1089/ten.TEA.2011.0022. Epub 2011 Sep 27.

8.

Ullrich ND, Fischer D, Kornblum C, Walter MC, Niggli E, Zorzato F, Treves S. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Hum Mutat. 2011 Mar;32(3):309-17. doi: 10.1002/humu.21431. Epub 2011 Feb 3.

7.

Ullrich ND, Fanchaouy M, Gusev K, Shirokova N, Niggli E. Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H1992-2003. doi: 10.1152/ajpheart.00602.2009. Epub 2009 Sep 25.

6.

Shkryl VM, Martins AS, Ullrich ND, Nowycky MC, Niggli E, Shirokova N. Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 2009 Sep;458(5):915-28. doi: 10.1007/s00424-009-0670-2. Epub 2009 Apr 22.

5.

Ullrich ND, Krust A, Collins P, MacLeod KT. Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2421-7. doi: 10.1152/ajpheart.01225.2007. Epub 2008 Apr 25.

4.

Ullrich ND, Koschak A, MacLeod KT. Oestrogen directly inhibits the cardiovascular L-type Ca2+ channel Cav1.2. Biochem Biophys Res Commun. 2007 Sep 21;361(2):522-7. Epub 2007 Jul 23.

3.

Tolmachov O, Ma YL, Themis M, Patel P, Spohr H, Macleod KT, Ullrich ND, Kienast Y, Coutelle C, Peters NS. Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc Disord. 2006 Jun 6;6:25.

2.

Ullrich N, Caplanusi A, Brône B, Hermans D, Larivière E, Nilius B, Van Driessche W, Eggermont J. Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral, but not apical, membrane of Caco-2 cells. Am J Physiol Cell Physiol. 2006 May;290(5):C1287-96. Epub 2005 Dec 7.

1.

Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B. Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium. 2005 Mar;37(3):267-78.

2.

Kiss E, Fischer C, Sauter JM, Sun J, Ullrich ND. The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes. Int J Mol Sci. 2022 Apr 18;23(8):4460. doi: 10.3390/ijms23084460. Review.

1.

Regev D, Baskin P, Dolgopyat I, Davidor M, Kermani F, Ullrich ND, Binah O. 9. Induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs); generation and enrichment protocols, immature and mature structure and function. In: Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition (Birbrair A, ed.) Academic Press 2021, pp. 191-226. Paperback ISBN 9780128222300; eBook ISBN 9780128224540

1.

Louch WE, Ullrich ND, Navedo MF, Macquaide N. Editorial: Nanodomain regulation of muscle physiology and alterations in disease. Front Physiol. 2022 Nov 29;13:1092304. doi: 10.3389/fphys.2022.1092304. eCollection 2022.